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WormBase Tree Display for Gene: WBGene00012936

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Name Class

WBGene00012936SMapS_parentSequenceY47D3A
IdentityVersion2
NameCGC_namepola-1Person_evidenceWBPerson30546
Sequence_nameY47D3A.29
Molecular_nameY47D3A.29
Y47D3A.29.1
CE32262
Other_nameCELE_Y47D3A.29Accession_evidenceNDBBX284603
Public_namepola-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:54WBPerson1971EventImportedInitial conversion from CDS class of WS125
205 Apr 2017 11:17:23WBPerson2970Name_changeCGC_namepola-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpola
Allele (164)
StrainWBStrain00051196
RNASeq_FPKM (74)
GO_annotation (27)
Contained_in_operonCEOP3720
Ortholog (42)
ParalogWBGene00008645Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021344Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionY47D3A.29 encodes the catalytic subunit of DNA polymerase alpha; large-scale RNAi screens indicate that Y47D3A.29 activity is essential for embryogenesis and required specifically for normal pronuclear migration, as well as normal nuclear position and cell division timing in early blastomeres.Paper_evidenceWBPaper00005654
WBPaper00006395
WBPaper00025054
Curator_confirmedWBPerson1843
Date_last_updated06 Apr 2007 00:00:00
Automated_descriptionPredicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and chromatin binding activity. Predicted to be involved in lagging strand elongation; leading strand elongation; and mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Is an ortholog of human POLA1 (DNA polymerase alpha 1, catalytic subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111840Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9173)
DOID:0111834Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9173)
Molecular_infoCorresponding_CDSY47D3A.29
Corresponding_CDS_historyY47D3A.29:wp89
Y47D3A.29b:wp279
Corresponding_transcriptY47D3A.29.1
Other_sequence (28)
Associated_featureWBsf645602
WBsf645603
WBsf659569
WBsf659570
WBsf1015933
WBsf1015934
WBsf225798
Experimental_infoRNAi_resultWBRNAi00075442Inferred_automaticallyRNAi_primary
WBRNAi00026719Inferred_automaticallyRNAi_primary
WBRNAi00009341Inferred_automaticallyRNAi_primary
WBRNAi00056755Inferred_automaticallyRNAi_primary
WBRNAi00026720Inferred_automaticallyRNAi_primary
WBRNAi00097143Inferred_automaticallyRNAi_primary
WBRNAi00114561Inferred_automaticallyRNAi_primary
WBRNAi00009342Inferred_automaticallyRNAi_primary
Expr_patternExpr1012413
Expr1035733
Expr1160213
Expr2014989
Expr2033224
Microarray_results (23)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037946:LIN-39_interacting
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00044037:eat-2_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:lin-35(n745)_upregulated
WBPaper00048690:male-Z1-Z4-daughter_enriched
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050743:elli-1(sam-3)_upregulated
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00051039:germline_enriched
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00051311:VGLN-1-interacting
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:mex-3(eu149)_downregulated
WBPaper00059027:neuron-synapses_enriched
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061340:Ciliated_amphid_neuron
WBPaper00061340:Ciliated_non_amphid_neuron
WBPaper00061340:Excretory_cell_parent
WBPaper00061340:Neuroblast_ASE_ASJ_AUA
WBPaper00061341:28C_24h_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:dpy-26-B0205.1
WBPaper00061699:daf-18(ok480)_upregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:efl-1(se1)_upregulated
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062056:lin-36(we31)_upregulated
WBPaper00062056:lin-36(we36)_upregulated
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062456:doxycycline_downregulated_CB4856_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064122:vulva_transcriptome
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064315:mes-3(bn199)_downregulated_EGCs
WBPaper00064315:mes-4(bn73)_downregulated_EGCs
WBPaper00064716:paraquat_upregulated
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_5_1
cgc4489_group_8
WBPaper00025032:cluster_122
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026980:intestine_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00036130:mir-243_down_regulated
WBPaper00036286:Pattern_B
WBPaper00040426:CYD-1_CDK-4_upregulated
WBPaper00040426:CYE-1_CDK-2AF_upregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00042274:tbx-2(bx59)_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045960:L1-L4-lethargus_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_F
[cgc6390]:intrinsic
Interaction (123)
Map_infoMapIIIPosition6.49087
PositivePositive_cloneY47D3AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00031307
WBPaper00035228
WBPaper00038491
WBPaper00054520
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene