WormBase Tree Display for Gene: WBGene00016625
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| WBGene00016625 | SMap | S_parent | Sequence | C44B7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aff-1 | Person_evidence | WBPerson3851 | |||||
| WBPerson493 | |||||||||
| Sequence_name | C44B7.3 | ||||||||
| Molecular_name | C44B7.3 | ||||||||
| C44B7.3.1 | |||||||||
| CE41369 | |||||||||
| Other_name | CELE_C44B7.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | aff-1 | ||||||||
| DB_info | Database | AceView | gene | 2H152 | |||||
| WormQTL | gene | WBGene00016625 | |||||||
| WormFlux | gene | WBGene00016625 | |||||||
| NDB | locus_tag | CELE_C44B7.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016625|UniProtKB=G5EGL9 | |||||||
| family | PTHR37415 | ||||||||
| NCBI | gene | 174123 | |||||||
| RefSeq | protein | NM_063001.6 | |||||||
| SwissProt | UniProtAcc | G5EGL9 | |||||||
| TREEFAM | TREEFAM_ID | TF318705 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGL9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 03 May 2007 10:33:07 | WBPerson2970 | Name_change | CGC_name | aff-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aff | ||||||||
| Reference_allele | WBVar00266475 | Paper_evidence | WBPaper00029363 | ||||||
| Allele (26) | |||||||||
| Strain | WBStrain00003881 | ||||||||
| WBStrain00000197 | |||||||||
| WBStrain00003884 | |||||||||
| WBStrain00003885 | |||||||||
| WBStrain00003886 | |||||||||
| WBStrain00047003 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00020506 | ||||||||
| 00020507 | |||||||||
| 00020508 | |||||||||
| 00020509 | |||||||||
| 00020510 | |||||||||
| 00020511 | |||||||||
| 00020512 | |||||||||
| 00020513 | |||||||||
| 00020514 | |||||||||
| 00020515 | |||||||||
| Ortholog (25) | |||||||||
| Paralog | WBGene00001159 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00023420 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aff-1 encodes a cell-surface protein required in late L4 larvae forvarious cell fusions, of which at least one (AC-utse) does not requireEFF-1; in vulval development, AFF-1 is required for fusion of the anchorcell (AC) with the utse syncytium, of A cells to one another, and of Dcells to one another; AFF-1 is also required for lateral seam cellfusions; since aff-1 mutants fail to mix AC with utse cytoplasm, AFF-1is probably required to begin cell fusion by forming intercellularpores; AFF-1 has no obvious non-nematode orthologs, but is paralogous toEFF-1 and C26D10.7; AFF-1 is predicted to be largely extracellular, witheight conserved predicted disulfide bonds in its ectodomain and a singleC-terminal transmembrane domain; AFF-1 is expressed in the AC, beginningaround the AC's invasion of basement membrane in mid-L3 larvae, andcontinuing until the AC's fusion to utse; AFF-1 is also expressed inutse, beginning in L4 larvae, after which AC-utse fusion immediatelyensues; in both AC and utse, AFF-1 expression requires FOS-1, and theaff-1 promoter has predicted FOS-1 binding sites; other sites of AFF-1expression include embryonic hyp5 cells, pharyngeal muscles (Pm3 andPm5), head and tail neurons, sheath cells of chemosensory neurons, andmale tail neurons; subcellularly, AFF-1::GFP localizes to plasmamembrane and (undefined) intracellular organelles; generally, AFF-1 isexpressed in cells whose fusion does not require EFF-1, which mayexplain why AFF-1 and EFF-1 are redundantly required for viability; heatshock-driven overexpression of AFF-1, even in an eff-1 null mutantbackground, can induce ectopic cell fusion, and heterologous AFF-1 caninduce insect Sf9 cells to fuse in vitro. | Paper_evidence | WBPaper00029363 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 04 Jun 2007 00:00:00 | ||||||||
| Automated_description | Involved in regulation of egg-laying behavior and syncytium formation by plasma membrane fusion. Located in plasma membrane. Expressed in anchor cell; egg-laying apparatus; epithelial cell; neurons; and pharyngeal muscle cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C44B7.3 | |||||||
| Corresponding_CDS_history | C44B7.3:wp88 | ||||||||
| C44B7.3:wp179 | |||||||||
| Corresponding_transcript | C44B7.3.1 | ||||||||
| Associated_feature | WBsf717693 | ||||||||
| WBsf988281 | |||||||||
| WBsf988282 | |||||||||
| WBsf988283 | |||||||||
| WBsf1012448 | |||||||||
| WBsf223240 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000620 | ||||||||
| WBCnstr00012152 | |||||||||
| WBCnstr00012153 | |||||||||
| WBCnstr00012510 | |||||||||
| WBCnstr00013132 | |||||||||
| WBCnstr00027928 | |||||||||
| WBCnstr00040834 | |||||||||
| WBCnstr00040835 | |||||||||
| Construct_product | WBCnstr00008101 | ||||||||
| WBCnstr00012152 | |||||||||
| WBCnstr00012153 | |||||||||
| WBCnstr00013132 | |||||||||
| WBCnstr00015967 | |||||||||
| WBCnstr00027928 | |||||||||
| WBCnstr00040835 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction | WBInteraction000188024 | ||||||||
| WBInteraction000365196 | |||||||||
| WBInteraction000502906 | |||||||||
| WBInteraction000502907 | |||||||||
| WBInteraction000503580 | |||||||||
| WBInteraction000520686 | |||||||||
| WBInteraction000520687 | |||||||||
| Map_info | Map | II | Position | 0.125694 | Error | 0.001371 | |||
| Positive | Positive_clone | C44B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (37) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
