WormBase Tree Display for Interaction: WBInteraction000501549
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| WBInteraction000501549 | Interaction_type | Regulatory | |||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004888 | Interactor_type | Trans_regulator | |
| WBGene00003000 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr3450 | ||||
| WBGene00019673 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00091656 | Interactor_type | Trans_regulator | ||
| Interaction_summary | The expression pattern of the LIN-11::GFP translational fusion construct (plin-11-ABCDE::GFP, which does not include the LIN-11 homeobox domain) was examined. This construct is expressed in wild-type animals both in the nucleus and in the cytoplasm of the {pi} cells and vulval cells. In the smo-1(ok359) uterus, the {pi} cells are not normally differentiated. The intensity of the LIN-11::GFP transgene in smo-1(ok359) was much weaker and diffused compared with the wild-type pattern (early L4 n = 23/26) and could be detected with high variability only in a few uterine cells (one to four cells in each side of the uterus, compared with six cells in the wild type). In a few cases the transgene was not expressed at all in the uterus (n = 3/26). Moreover, whereas in the wild-type developing uterus the {pi} cells migrate after dividing, in the smo-1(ok359) animals the LIN-11::GFP-expressing cells were clustered and failed to occupy the correct stereotypic positions. | ||||
| Detection_method | Reporter_gene | [lin-11::gfp] translational fusion. | |||
| Paper | WBPaper00024467 |
