WormBase Tree Display for Transgene: WBTransgene00004665
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WBTransgene00004665 | Public_name | syIs25 | |||||||
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Summary | [pJM3QL + pMH86] | ||||||||
Synonym | [gpa-3::gpa-3(QL)] | ||||||||
gpa-3QL | |||||||||
Construction | Construct | WBCnstr00004647 | |||||||
Construction_summary | QL means a constitutive activating mutation. | ||||||||
Genetic_information | Integrated | ||||||||
Map | X | ||||||||
Map_evidence | Paper_evidence | WBPaper00029060 | |||||||
Phenotype (15) | |||||||||
Phenotype_not_observed | WBPhenotype:0000679 | Paper_evidence | WBPaper00048972 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Next, we tested whether gpa-3QL affects GFP::RAB-5. Interestingly, in gpa-3QL(syIs25) animals GFP::RAB-5 fluorescence intensity was reduced both at the dendritic ending and in the cell body (Fig 6A), although quantification of the fluorescence intensities did not reveal a significant difference between wild type and gpa-3QL animals (Fig 6D and 6E). However, these results are in accordance with the hypothesis that endocytosis is affected in gpa-3QL animals." | Paper_evidence | WBPaper00048972 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00048972 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | GFP::RAB-5 | Paper_evidence | WBPaper00048972 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001414 | Paper_evidence | WBPaper00003465 | |||||||
Curator_confirmed | WBPerson291 | ||||||||
Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00003465 | ||||||
Curator_confirmed | WBPerson291 | ||||||||
WBPhenotype:0001780 | Paper_evidence | WBPaper00029060 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants show normal butanone enhancement | Paper_evidence | WBPaper00029060 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00029060 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00029060 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00029060 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays | Paper_evidence | WBPaper00029060 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0002096 | Paper_evidence | WBPaper00042072 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In gpa-3QL animals we observed distinct AMAN-2 structures similar to those observed in wild type animals. | Paper_evidence | WBPaper00042072 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Caused_by_gene | WBGene00001665 | Paper_evidence | WBPaper00042072 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Used_for | Interactor (10) | ||||||||
Associated_with | Strain | WBStrain00030854 | |||||||
Reference | WBPaper00003465 | ||||||||
WBPaper00028950 | |||||||||
WBPaper00029060 | |||||||||
WBPaper00033456 | |||||||||
WBPaper00035927 | |||||||||
WBPaper00036302 | |||||||||
WBPaper00042072 | |||||||||
WBPaper00048972 | |||||||||
Species | Caenorhabditis elegans |