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WormBase Tree Display for Variation: WBVar00000463

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Name Class

WBVar00000463EvidencePaper_evidenceWBPaper00001677
NamePublic_namebn18
Other_nameCE00237:p.Ala1034Thr
F02A9.6.1:c.3100G>A
HGVSgCHROMOSOME_III:g.9098493G>A
Sequence_detailsSMapS_parentSequenceF02A9
Flanking_sequencesattgatgaattggaccggaatggtatgactcattgatgctagtagcacgtgaactcggaa
Mapping_targetF02A9
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001677
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005672
WBStrain00031270
WBStrain00052426
LaboratorySS
StatusLive
AffectsGeneWBGene00001609
TranscriptF02A9.6.1 (12)
Interactor (14)
IsolationMutagenEMS
GeneticsInterpolated_map_positionIII0.163974
DescriptionPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Remarktemperature-sensitive mutation that causes embryonic lethality at its restrictive temperaturePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
WBPhenotype:0000061Paper_evidenceWBPaper00046170
Curator_confirmedWBPerson5092
RemarkIn analysis of glp-1(bn18), both N2 and glp-1 animals were upshifted from 15 to 25 degrees Celsius from the mid-L1 stage until the first day of adulthood, then we analysed lifespan at 20 degrees Celsius.Paper_evidenceWBPaper00046170
Curator_confirmedWBPerson5092
WBPhenotype:0000315Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals had a lower arousal threshold to mechanosensory stimuli than control animals; animals responded more frequently to stimuli than control quiescent animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_assayTemperature24Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0000641Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals exhibited increased basal locomotion activity, twice the number of body bends per minute than observed for control animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_assayTemperature24Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040544
Curator_confirmedWBPerson712
WBPhenotype:0001408Paper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
RemarkNuclear METT-10 is uniformly detected in distally located meiotic nuclei in shifted glp-1(bn18) animals in which almost all germ cells have entered meiosisPaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00034719
Curator_confirmedWBPerson2021
WBPhenotype:0001524Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals exhibited increased L4/A quiescence compared to control animals. Expression of GLP-1(IC) in ciliated neurons partially restored quiescence in glp-1(tslf) animals.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_assayTemperature24Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000412Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals responded robustly to octanol.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001966Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Phenotype_assayTemperature24Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
ReferenceWBPaper00038400
WBPaper00040544
WBPaper00034719
WBPaper00046170
WBPaper00061946
WBPaper00064401
RemarkA1034T, intracellular domain
MethodSubstitution_allele