WormBase Tree Display for Variation: WBVar00088324

WBVar00088324 Evidence: Paper_evidence: WBPaper00003726
  Name: Public_name: ku123
    Other_name: CE09685:p.Cys302Tyr
      F26E4.1.1:c.905G>A
    HGVSg: CHROMOSOME_I:g.9755881G>A
  Sequence_details: SMap: S_parent: Sequence: F26E4
    Flanking_sequences: gattgtgtgatatgagagatcgtgctctat tgatgcgtatgctaaaagtgcgtttggttc
    Mapping_target: F26E4
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00003726
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026511
      WBStrain00026525
    Laboratory: MH
    Status: Live
  Affects: Gene: WBGene00006352
    Transcript: F26E4.1.1 (12)
    Interactor: WBInteraction000002328
      WBInteraction000052121
      WBInteraction000524419
  Genetics: Interpolated_map_position: I 3.89251
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 6% of fertile animals (n=34) exhibited an egg laying defect. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-29(e403) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0000698 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 2% animals (n=26) are aberrant in induction of VPCs; <3 of the VPCs, which are induced in wild type animals (P5.p to P7.p), are induced in these animals, as scored by Nomarski optics. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-29(e403) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000688 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 0% animals produced progeny (n=34). Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-29(e403) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0000700 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 0% animals display one or more ectopic pseudovulvae (n=117). Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-29(e403) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0001272 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: On average 2.97 VCPs (n=26 animals) are induced to adopt a vulval cell fate, which is near that of wild type, (3/6 VPCs induced n=29). VPCs and fate adoption were scored by Nomarski optics. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Vulval induction was scored in late L3 to early L4 stage larvae, under Normarski optics. All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-29(e403) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
  Reference: WBPaper00026863
    WBPaper00022705
    WBPaper00017196
    WBPaper00023691
    WBPaper00010199
  Method: Substitution_allele