WormBase Tree Display for Gene: WBGene00006352
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| WBGene00006352 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sur-6 | Person_evidence | WBPerson237 | |||||
| Sequence_name | F26E4.1 | ||||||||
| Molecular_name | F26E4.1 | ||||||||
| F26E4.1.1 | |||||||||
| CE09685 | |||||||||
| Other_name | CELE_F26E4.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | sur-6 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sur | ||||||||
| Allele (58) | |||||||||
| Legacy_information | [Sieburth DS] sur for suppressor of ras. suppresses the multivulva phenotype caused by let-60(n1046gf). ku123 causes no phenotype. ku123 is dominant | ||||||||
| Strain | WBStrain00001777 | ||||||||
| WBStrain00026511 | |||||||||
| WBStrain00026525 | |||||||||
| WBStrain00035415 | |||||||||
| WBStrain00037362 | |||||||||
| WBStrain00007339 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (52) | |||||||||
| Structured_description | Concise_description | sur-6 encodes a regulatory (B) subunit of serine/threonine protein phosphatase 2A (PP2A-B); sur-6 was initially identified in screens for mutations that suppress the Multivulva phenotype produced by an activated let-60/Ras mutation and enhance the vulvaless and larval lethality phenotype of a hypomorphic lin-45/Raf mutation; in addition, RNAi experiments demonstrate that sur-6 activity is also essential for embryonic development; genetic studies indicate that during vulval development SUR-6 likely acts with the KSR-1 kinase in a parallel pathway that positively regulates RTK-Ras-MAP kinase signaling. | Paper_evidence | WBPaper00003726 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9305) | ||||
| DOID:0050962 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9305) | ||||||
| DOID:9074 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9305) | ||||||
| DOID:936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9305) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9305) | ||||||
| Molecular_info | Corresponding_CDS | F26E4.1 | |||||||
| Corresponding_transcript | F26E4.1.1 | ||||||||
| Other_sequence (33) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (42) | ||||||||
| Expr_pattern | Chronogram2080 | ||||||||
| Expr5874 | |||||||||
| Expr15731 | |||||||||
| Expr1017534 | |||||||||
| Expr1032559 | |||||||||
| Expr1149549 | |||||||||
| Expr2017137 | |||||||||
| Expr2035273 | |||||||||
| Drives_construct | WBCnstr00002590 | ||||||||
| WBCnstr00034393 | |||||||||
| Construct_product | WBCnstr00034393 | ||||||||
| Antibody | WBAntibody00002241 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (185) | |||||||||
| WBProcess | WBbiopr:00000071 | ||||||||
| Map_info | Map | I | Position | 3.89256 | Error | 0.002576 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | qDf8 | |||||||
| qDf9 | |||||||||
| Positive_clone | F26E4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| K02A11 | |||||||||
| Negative | Outside_rearr | qDf5 | |||||||
| Negative_clone | F26E4 | ||||||||
| Mapping_data | Multi_point | 3575 | |||||||
| 4838 | |||||||||
| 4866 | |||||||||
| 4802 | |||||||||
| 4836 | |||||||||
| Pos_neg_data | 9160 | ||||||||
| 9161 | |||||||||
| 9162 | |||||||||
| Reference (42) | |||||||||
| Method | Gene |
