WormBase Tree Display for Variation: WBVar00088923

WBVar00088923 Evidence: Paper_evidence: WBPaper00003903
  Name: Public_name: mg280
    Other_name: ZK1290.2a.1:c.86+68_854del
      ZK1290.2b.1:c.-264+68_545del
    HGVSg: CHROMOSOME_II:g.7549511_7550816del
  Sequence_details: SMap: S_parent: Sequence: ZK1290
    Flanking_sequences: ccgttcaattttgaactgtaggagtgaact atactcggaaaataatattccgcaactaga
    Mapping_target: ZK1290
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00006655
      WBStrain00007901
      WBStrain00027519
      WBStrain00049490
      WBStrain00055118
      WBStrain00055121
    Laboratory: GR
      MT
    Status: Live
  Affects: Gene: WBGene00197293
      WBGene00006600
    Transcript: ZK1290.2b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZK1290.2b.1:c.-264+68_545del
        cDNA_position: ?-875
        CDS_position: ?-545
        Protein_position: ?-182
        Intron_number: 1-6/11
        Exon_number: 2-7/12
      ZK1290.2a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZK1290.2a.1:c.86+68_854del
        cDNA_position: ?-877
        CDS_position: ?-854
        Protein_position: ?-285
        Intron_number: 2-7/12
        Exon_number: 3-8/13
      ZK1290.18 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-74
        Exon_number: 1/1
    Interactor: WBInteraction000500144
      WBInteraction000502728
      WBInteraction000525337
      WBInteraction000537565
      WBInteraction000537566
      WBInteraction000541577
  Genetics: Interpolated_map_position: II 0.504577
    Mapping_data: In_multi_point: 4733
  Description: Phenotype (45)
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00050142
        Curator_confirmed: WBPerson2987
        Remark: "As a control for the specificity of serotonergic signaling to neuronal and cell-non-autonomous induction of the response, we exposed tph-1 mutant animals to cell-autonomous stressors, namely paraquat and cco-1 RNAi. These strains showed the same level of induction of hsp-6::GFP as controls, indicating that serotonin is required specifically for neuronal initiation of this response (Figure S4D)." Paper_evidence: WBPaper00050142
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0034514 PATO:0000460 Paper_evidence: WBPaper00050142
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: zcIs13 [hsp-6p::GFP] Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
            zcIs13 [hsp-6p::GFP]; cco-1(RNAi) Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000631 Paper_evidence: WBPaper00035198
        Curator_confirmed: WBPerson712
        Remark: Animals do not exhibit anterior convulsions when treated with pentylenetetrazole(PTZ). Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004251 Paper_evidence: WBPaper00035198
              Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00031241
        Curator_confirmed: WBPerson712
        Remark: Pre-exposure to mianserin blocked serotonin-induced egg laying as it does for N2 animals. Paper_evidence: WBPaper00031241
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00031241
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were pre-exposed to 50uM mianserin. Paper_evidence: WBPaper00031241
              Curator_confirmed: WBPerson712
      WBPhenotype:0001072 Paper_evidence: WBPaper00035327
        Curator_confirmed: WBPerson2021
        Remark: tph-1 mutants displayed a wild type phenotype on non-eatable food Paper_evidence: WBPaper00035327
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001101 Paper_evidence: WBPaper00038382
        Curator_confirmed: WBPerson712
        Remark: Clozapine-induced increases in egg laying was present. Paper_evidence: WBPaper00038382
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003634 Paper_evidence: WBPaper00038382
              Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001780 Paper_evidence: WBPaper00029060
        Curator_confirmed: WBPerson2021
        Remark: Mutants show normal butanone enhancement Paper_evidence: WBPaper00029060
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00029060
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays Paper_evidence: WBPaper00029060
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001817 Paper_evidence: WBPaper00032335
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type. Paper_evidence: WBPaper00032335
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
  Disease_info: Models_disease: DOID:809
      DOID:1574
    Models_disease_in_annotation: WBDOannot00000681
      WBDOannot00000714
  Reference: WBPaper00038382
    WBPaper00043908
    WBPaper00031936
    WBPaper00035198
    WBPaper00032221
    WBPaper00036766
    WBPaper00029060
    WBPaper00035327
    WBPaper00003903
    WBPaper00018301
    WBPaper00025798
    WBPaper00010687
    WBPaper00031241
    WBPaper00031694
    WBPaper00031915
    WBPaper00032335
    WBPaper00028900
    WBPaper00031438
    WBPaper00032067
    WBPaper00033168
    WBPaper00019518
    WBPaper00025761
    WBPaper00035315
    WBPaper00019020
    WBPaper00019156
    WBPaper00024107
    WBPaper00042548
    WBPaper00042154
    WBPaper00044094
    WBPaper00044624
    WBPaper00045372
    WBPaper00048926
    WBPaper00049131
    WBPaper00050142
    WBPaper00050740
    WBPaper00049802
    WBPaper00059382
    WBPaper00060921
    WBPaper00064927
    WBPaper00065802
    WBPaper00065715
  Remark: Variation stub generated from the April 2021 NN VFP dataset.
    Variation stub/paper connection generated from the May 2021 NN VFP dataset.
    Created by WBPerson1983 from the NN_VFP_triage_pipeline
  Method: Deletion_allele