WormBase Tree Display for Variation: WBVar00089452
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WBVar00089452 | Name | Public_name | n363 | |||||
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Sequence_details | SeqStatus | Pending_curation | ||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00026725 | |||||||
Laboratory | MT | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00001648 | ||||||
Interactor | WBInteraction000524572 | |||||||
Description | Phenotype (11) | |||||||
Phenotype_not_observed | WBPhenotype:0000481 | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | goa-1(n363) mutants exhibited a wild type avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 2a). | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
goa-1(n363) mutants exhibited a wild type avoidance response to 10 millimolar quinine compared to wild type controls (Figure 2a). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Affected_by | Molecule | WBMol:00003633 | Paper_evidence | WBPaper00037778 | ||||
Curator_confirmed | WBPerson2987 | |||||||
WBMol:00003904 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0000680 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals were not blocked in halothane induced aldicarb resistance, except at very high concentrations of the volatile anesthetic as observed in WT. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBMol:00003650 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001182 | Paper_evidence | WBPaper00032082 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Fat levels were similar to that seen in wild-type but are reduced when compared to daf-7(e1375) as determined by Sudan Black assay (described in Kimura et al., 1997). | Paper_evidence | WBPaper00032082 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay (2) | ||||||||
WBPhenotype:0001612 | Paper_evidence | WBPaper00006275 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Mean egg-laying frequency decreased as observed for N2 animals when treated with ethanol. | Paper_evidence | WBPaper00006275 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001618 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibit an EC50 of ~0.48 for halothane, similar to N2 (EC50 ~0.42) vol%, as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Variation_effect | Null | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | Dispersal assay followed the protocol reported in Crowder et al. 1996 and van Swinderen et al. 1997. | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0002199 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | The goa-1(n363) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a) | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
Disease_info | Models_disease | DOID:0050709 | ||||||
Models_disease_in_annotation | WBDOannot00001090 | |||||||
Reference (12) | ||||||||
Method | Allele |