WormBase Tree Display for Variation: WBVar00089688

WBVar00089688 Evidence: Paper_evidence: WBPaper00003698
  Name: Public_name: n703
    Other_name: F43G9.14:n.56C>T
      F43G9.19:n.50G>A
    HGVSg: CHROMOSOME_I:g.8633348G>A
  Sequence_details: SMap: S_parent: Sequence: F43G9
    Flanking_sequences: tagaaaatagacagacggcgttgaaattag tatgatgtaacaggtcatgaactgtgtcac
    Mapping_target: F43G9
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00003698
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (14)
    Laboratory: MT
    Status: Live
  Linked_to: WBVar00089689
  Affects: Gene: WBGene00000468
      WBGene00195590
      WBGene00201162
    Transcript: F43G9.19 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        HGVSc: F43G9.19:n.50G>A
        cDNA_position: 50
        Exon_number: 1/1
      F43G9.14 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        HGVSc: F43G9.14:n.56C>T
        cDNA_position: 56
        Exon_number: 1/1
    Interactor: WBInteraction000004099
      WBInteraction000503981
      WBInteraction000521994
      WBInteraction000524377
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: I 3.01058
    Mapping_data: In_multi_point (12)
  Description: Phenotype: WBPhenotype:0000184 Paper_evidence: WBPaper00031670
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited 100, 99 and 94% NSM sister cell survival at 15, 20 and 25C, respectively. Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031670
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 15, 20, 25 Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
          Genotype: bcIs25[Ptph-1::GFP] Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
      WBPhenotype:0000266 Paper_evidence: WBPaper00031670
        Curator_confirmed: WBPerson712
        Remark: Division of the NSM neuroblast sometimes occurred along the ventral/medial to dorsal/lateral axis, which is reverse from the wild type cleavage plane, along the ventral/lateral to dorsal/media axis. Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031670
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: bcIs25; dtIs372 Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
      WBPhenotype:0001172 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: sisters of NSM, I2 fail to undergo programmed cell death (gf allele) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001585 Paper_evidence: WBPaper00031670
        Curator_confirmed: WBPerson712
        Remark: On average in wild-type animals, NSM sister cell is 0.46 times the size of NSM, whereas it was 0.94 in n703 animals. Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031670
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: tIs38 (Ppie-1gfp::ph(PLC1d1)) Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
      WBPhenotype:0001681 Paper_evidence: WBPaper00031670
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit altered placement of the mitotic spindle along the cell division axis in the NSM neuroblast. Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00031670
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031670
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: bcIs25; dtIs372 Paper_evidence: WBPaper00031670
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0001271 Paper_evidence: WBPaper00004574
        Curator_confirmed: WBPerson712
        Remark: These mutants were not more susceptible than wild-type worms to Salmonella-mediated killing Paper_evidence: WBPaper00004574
            Curator_confirmed: WBPerson712
      WBPhenotype:0001652 Paper_evidence: WBPaper00032446
        Curator_confirmed: WBPerson2021
  Reference: WBPaper00032446
    WBPaper00013699
    WBPaper00016476
    WBPaper00004574
    WBPaper00031670
    WBPaper00015203
  Remark: Manually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00000468 Genomic_neighbourhood
  Method: Substitution_allele