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WormBase Tree Display for Variation: WBVar00089736

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Name Class

WBVar00089736EvidencePaper_evidenceWBPaper00032289
NamePublic_namen765
Other_nameCE15381:p.Pro208LysfsTer16
ZK662.4.2:c.622_812del
ZK662.4.1:c.622_812del
HGVSgCHROMOSOME_X:g.15727663_15727853del
Sequence_detailsSMapS_parentSequenceZK678
Flanking_sequencesTCAAATGTCAAGTTTACGAACATTGTGTGTAAGGTAAATTTAGCGTTTTTAACCTTTATA
Mapping_targetZK678
Type_of_mutationInsertion
Deletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000020
WBStrain00000028
WBStrain00000188
WBStrain00000303
WBStrain00000313
WBStrain00000314
WBStrain00000315
WBStrain00000316
WBStrain00000317
WBStrain00004017
WBStrain00004018
WBStrain00004019
WBStrain00004849
WBStrain00005226
WBStrain00005227
WBStrain00005248
WBStrain00005249
WBStrain00005251
WBStrain00005252
WBStrain00005255
WBStrain00005273
WBStrain00005284
WBStrain00005355
WBStrain00005361
WBStrain00005365
WBStrain00005550
WBStrain00005551
WBStrain00005552
WBStrain00005553
WBStrain00005554
WBStrain00005555
WBStrain00005556
WBStrain00005557
WBStrain00005558
WBStrain00005559
WBStrain00005560
WBStrain00005561
WBStrain00005562
WBStrain00005563
WBStrain00005564
WBStrain00005565
WBStrain00005575
WBStrain00005577
WBStrain00005578
WBStrain00005579
WBStrain00005580
WBStrain00005581
WBStrain00005582
WBStrain00005583
WBStrain00005600
WBStrain00005837
WBStrain00006667
WBStrain00006671
WBStrain00006674
WBStrain00006699
WBStrain00006700
WBStrain00007187
WBStrain00007671
WBStrain00008269
WBStrain00008270
WBStrain00008271
WBStrain00008278
WBStrain00008279
WBStrain00008280
WBStrain00008281
WBStrain00008282
WBStrain00008283
WBStrain00008284
WBStrain00008285
WBStrain00008286
WBStrain00008287
WBStrain00008288
WBStrain00008289
WBStrain00008290
WBStrain00008291
WBStrain00022682
WBStrain00022843
WBStrain00023457
WBStrain00023623
WBStrain00024134
WBStrain00024140
WBStrain00024153
WBStrain00026380
WBStrain00026382
WBStrain00026387
WBStrain00026388
WBStrain00026389
WBStrain00026391
WBStrain00026392
WBStrain00026397
WBStrain00026398
WBStrain00026416
WBStrain00026417
WBStrain00026418
WBStrain00026419
WBStrain00026420
WBStrain00026421
WBStrain00026540
WBStrain00026541
WBStrain00026971
WBStrain00027005
WBStrain00027012
WBStrain00027064
WBStrain00027102
WBStrain00027314
WBStrain00027315
WBStrain00027328
WBStrain00027367
WBStrain00027368
WBStrain00027440
WBStrain00027601
WBStrain00027602
WBStrain00027617
WBStrain00028647
WBStrain00029045
WBStrain00029065
WBStrain00029251
WBStrain00029290
WBStrain00029467
WBStrain00030930
WBStrain00031121
WBStrain00033483
WBStrain00034639
WBStrain00034640
WBStrain00034655
WBStrain00035027
WBStrain00035028
WBStrain00035029
WBStrain00035090
WBStrain00035099
WBStrain00040158
WBStrain00040159
WBStrain00040160
WBStrain00040161
WBStrain00040162
WBStrain00040163
WBStrain00040164
WBStrain00040165
WBStrain00040169
WBStrain00040633
WBStrain00040883
WBStrain00040884
WBStrain00040885
WBStrain00040886
WBStrain00040887
WBStrain00040888
WBStrain00040889
WBStrain00040890
WBStrain00040891
WBStrain00040892
WBStrain00040893
WBStrain00040894
WBStrain00040895
WBStrain00040896
WBStrain00040897
WBStrain00040898
WBStrain00040899
WBStrain00040900
WBStrain00040901
WBStrain00040902
WBStrain00040903
WBStrain00040904
WBStrain00040905
WBStrain00040906
WBStrain00040909
WBStrain00040910
WBStrain00040911
WBStrain00040912
WBStrain00044114
WBStrain00051804
WBStrain00051805
WBStrain00051806
WBStrain00052189
WBStrain00053854
WBStrain00053860
WBStrain00054860
WBStrain00054882
WBStrain00054883
WBStrain00055701
LaboratoryMT
NM
CX
StatusLive
AffectsGeneWBGene00003004
WBGene00023498
WBGene00023497
TranscriptZK662.4.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScZK662.4.1:c.622_812del
HGVSpCE15381:p.Pro208LysfsTer16
cDNA_position628-818
CDS_position622-812
Protein_position208-271
Exon_number4/10
Codon_changeCCAAACGAAGAGATTTGCAAGCTGGTTGAAGAGAGTGCAGTTGTCAAACGATACAACGTTTGCTTCTACAACTACGTTACCCGTTTTGTGGCCGATTTGATGGAAATTGAAGAGTTTTCCAGTGGGCTGACACAATTGCGAACATTTGTTCGTTATATGAAACAAAATTCGGATATGTATAGCAAATTTAGa/a
Amino_acid_changePNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFR/X
ZK662.4.2VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScZK662.4.2:c.622_812del
HGVSpCE15381:p.Pro208LysfsTer16
cDNA_position634-824
CDS_position622-812
Protein_position208-271
Exon_number4/11
Codon_changeCCAAACGAAGAGATTTGCAAGCTGGTTGAAGAGAGTGCAGTTGTCAAACGATACAACGTTTGCTTCTACAACTACGTTACCCGTTTTGTGGCCGATTTGATGGAAATTGAAGAGTTTTCCAGTGGGCTGACACAATTGCGAACATTTGTTCGTTATATGAAACAAAATTCGGATATGTATAGCAAATTTAGa/a
Amino_acid_changePNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFR/X
Interactor (64)
GeneticsInterpolated_map_positionX22.945
Mapping_dataIn_2_point4457
4458
7082
In_multi_point (19)
In_pos_neg_data4461
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Remark13% of fertile animals (n=32) exhibited an egg laying defect.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000099Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
RemarkThe lin-15(n765) mutation resulted in 20% of animals with the '0 P11.p' phenotype (P11 adopts a P12 fate). No animals exhibited the '2 P11.p' phenotype (P12 adopts a P11 fate).Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
PenetranceIncompletePaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004410PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBbt:0004409PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0000137Paper_evidenceWBPaper00032289
Curator_confirmedWBPerson712
Remarklin-15A transcripts were reduced >10-fold as assayed by qRT-PCR (data not shown).Paper_evidenceWBPaper00032289
Curator_confirmedWBPerson712
WBPhenotype:0000218Paper_evidenceWBPaper00026863
WBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson712
WBPerson2987
RemarkOn average 5.82 VCPs (n=24 animals) are induced to adopt a vulval cell fate, which is increased compared to wild type (3/6 VPCs induced, n=29). VPCs and fate adoption were scored by Nomarski optics.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
The lin-15(n765) mutation resulted in more than the expected number of induced vulval precursor cells (4.86 on average instead of 3.0 in wild type)Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
lin-15(n765) mutant animals exhibited an average of 5.37 induced vulval precursor cells (Table I), as opposed to 3.0 in wild typePaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007809PATO:0000460Paper_evidenceWBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson2987
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown at 18.2 degrees CelsiusPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Temperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
18.2Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0000688Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Remark3% animals produced progeny (n=41).Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000700Paper_evidenceWBPaper00000762
WBPaper00026863
WBPaper00032309
WBPaper00005344
WBPaper00005255
WBPaper00006388
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
WBPerson2987
Remark2 or 3 large ventral protrusions. n765 has a temperature-dependent maternal effect ( at 20 C)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
100% animals display one or more ectopic pseudovulvae (n=343).Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
100% of animals were Muv.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
wildtype at 15C, Muv at 25C, maternal effect Muv at 20CPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
95% of lin-15(n765) animals have multiple vulvaPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
Table 1Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
Table IPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
PenetranceIncomplete55% penetrantPaper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
HighPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
91% penetrantPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
CompletePaper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006748PATO:0000460Paper_evidenceWBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson2987
Life_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00000762
WBPaper00026863
Curator_confirmedWBPerson2021
WBPerson712
25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayTreatment (2)
Temperature20, 25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
17.5Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
18.2Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Genotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001258Paper_evidenceWBPaper00027135
Curator_confirmedWBPerson557
WBPhenotype:0001414Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RemarkHemizygous n765 males do not mate at the restricted temperaturePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceCompletePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Genotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000698Paper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Remark0% animals (n=24) are aberrant in induction of VPCs as scored by Nomarski optics.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Reference (26)
RemarkManually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00023498 WBGene00003004 Genomic_neighbourhood
MethodDeletion_and_insertion_allele