WormBase Tree Display for Variation: WBVar00091489

WBVar00091489 Evidence: Person_evidence: WBPerson7734
  Name: Public_name: ok171
    Other_name (14)
    HGVSg: CHROMOSOME_X:g.10609441_10611936del
  Sequence_details: SMap: S_parent: Sequence: M79
    Flanking_sequences: ggatgcattttaacatacgtactcgagttc cggaatttgacttcttgtgtgatgaacatc
    Mapping_target: M79
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040670
      WBStrain00040671
      WBStrain00040673
    Laboratory: RB
      FB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00000018
    Transcript: M79.1f.1 (11)
      M79.1c.1 (11)
      M79.1e.1 (11)
      M79.1d.1 (11)
      M79.1g.1 (11)
      M79.1a.1 (11)
      M79.1b.1 (11)
  Genetics: Mapping_data: In_multi_point: 4134
  Description: Phenotype: WBPhenotype:0000386 Paper_evidence: WBPaper00033433
        Curator_confirmed: WBPerson2987
        Remark: Copper-induced germ cell apoptosis was slightly increased in abl-1(ok171) mutants (Figure 3B). Paper_evidence: WBPaper00033433
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00002862 Paper_evidence: WBPaper00033433
              Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Worms were exposed to 10 micromolar of copper for 12 hours Paper_evidence: WBPaper00033433
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000436 Paper_evidence: WBPaper00032243
        Curator_confirmed: WBPerson712
        Remark: Animals showed an increase in intensity of nuclear CED-4 staining, indicative of nuclear CED-4 redistribution, after irradiation. Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005175 PATO:0000460 Paper_evidence: WBPaper00032243
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: After animals were exposed to 120 Gy, germ cells were released from gonads and stained with antibodies against C. elegans CED-4 and Ce-lamin. Paper_evidence: WBPaper00032243
              Curator_confirmed: WBPerson712
      WBPhenotype:0000730 Paper_evidence: WBPaper00032243
        Curator_confirmed: WBPerson712
        Remark: Animals displayed increased baseline germ cell death. Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005175 PATO:0000460 Paper_evidence: WBPaper00032243
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Germ cell corpses were counted after 120Gy. Data (meanSEM) are collated from 10-15 worms/group. Paper_evidence: WBPaper00032243
              Curator_confirmed: WBPerson712
      WBPhenotype:0001391 Paper_evidence: WBPaper00032243
        Curator_confirmed: WBPerson712
        Remark: Animals showed an increase in radiation-induced germ cell apoptosis. Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005784 PATO:0000460 Paper_evidence: WBPaper00032243
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Germ cell corpses were counted after 120Gy. Data (meanSEM) are collated from 10-15 worms/group. Paper_evidence: WBPaper00032243
              Curator_confirmed: WBPerson712
      WBPhenotype:0001742 Paper_evidence: WBPaper00032243
        Curator_confirmed: WBPerson712
        Remark: Animals showed prominent mitochondrial perinuclear distribution of ceramide upon irradiation. Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032243
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005175 PATO:0000460 Paper_evidence: WBPaper00032243
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Gonads from unirradiated or irradiated worms were dissected, opened by freeze-cracking, and then stained with MID15B4, a specific anti-ceramide antibody. Mitochondria were localized with an antibody to the mitochondrial marker protein OxPhos Complex IV subunit I (COX-IV) or by Rhodamine B staining. Paper_evidence: WBPaper00032243
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0001851 Paper_evidence: WBPaper00027700
        Curator_confirmed: WBPerson2021
        Remark: Mutants did not display significant radiosensitivity when compared with WT N2 C. elegans Paper_evidence: WBPaper00027700
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00027700
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00027700
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 100-400 Gy radiation Paper_evidence: WBPaper00027700
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00024301
    WBPaper00027700
    WBPaper00017950
    WBPaper00032243
    WBPaper00033433
    WBPaper00010154
  Remark (4)
  Method: KO_consortium_allele