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WormBase Tree Display for Variation: WBVar00092155

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Name Class

WBVar00092155NamePublic_nameok880
Other_nameCE39724:p.His598GlnfsTer15
F13E6.6.1:c.1794_2412del
HGVSgCHROMOSOME_X:g.10700374_10701544del
Sequence_detailsSMapS_parentSequenceF13E6
Flanking_sequencesacaaaaacttaccttttcaacttctgctcttgcgatctggataccaagccacgatccatg
Mapping_targetF13E6
Type_of_mutationDeletion
PCR_productok880_external
ok880_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00031686
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00006468
TranscriptF13E6.6.1 (11)
InteractorWBInteraction000052320
WBInteraction000534902
WBInteraction000534903
WBInteraction000534904
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0000633Paper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
RemarkBranch defects scored in PLM neuron.Paper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
PenetranceLowPaper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
WBPhenotype:0001911Paper_evidenceWBPaper00049131
Curator_confirmedWBPerson712
RemarkWe found that the rhgf-1(ok880) and rhgf-1(gk217) mutants were defective in axon regeneration (Fig. 3d and Supplementary Table 2).Paper_evidenceWBPaper00049131
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000059Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkGrowth was not significantly different from wild type. Growth was not arrested by the expression of constitutively active GPA-12.Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotypehs::GPA-12(Q205L)Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkThe average size, fluorescence level and number of SNB-1::CFP puncta in cholinergic motor neurons was not significantly different from wild type.Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotypeSNB-1::CFPPaper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0000634Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkPumping was not significantly different from wild type. Pumping was decreased substantially by the expression of constitutively active GPA-12.Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotyperhgf-1(ok880) x4 hs::GPA-12(Q205L)Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkUNC-13::YFP puncta distribution is similar to wild type in the dorsal cord and suppresses increased puncta due to constitutively active GPA-12.Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotypeUNC-13S::YFP hs::GPA-12(Q205L)Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0000680Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkParalysis to 1mM aldicarb is indistinguishable from wild type as measured by the percent paralyzed over time. Heat shocked animals were slightly hypersensitive. Completely suppresses Aldicarb hypersensitivity due to constitutively active GPA-12 (Q205L).Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotypehs::GPA-12(Q205L)Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0000845Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
RemarkThis mutation has no effect on the time course of paralysis induced by 100uM levamisole compared to wild type.Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
Phenotype_assayGenotyperhgf-1(ok880) x4Paper_evidenceWBPaper00028856
Curator_confirmedWBPerson712
WBPhenotype:0001413Paper_evidenceWBPaper00040813
Curator_confirmedWBPerson2706
WBPhenotype:0002469Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkThe probability and size of response to plate taps decreased with continued taps applied with a 10s interval, similar to the response of N2 animals.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0004027Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAnimals exhibit an escape response (reversal) similar to N2 animals upon an initial plate tap.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
ReferenceWBPaper00038487
WBPaper00040813
WBPaper00028856
WBPaper00045955
WBPaper00049131
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele