WormBase Tree Display for Variation: WBVar00092811

WBVar00092811 Name: Public_name: ok1603
    Other_name: F56A11.1.1:c.54_388-1270delinsATTTGGCAAATTTGGCAAATTTGCCGGCAAATTTGGCAAATTTGCCTA
    HGVSg: CHROMOSOME_IV:g.572876_574778delinsATTTGGCAAATTTGGCAAATTTGCCGGCAAATTTGGCAAATTTGCCTA
  Sequence_details: SMap: S_parent: Sequence: F56A11
    Flanking_sequences: aaacataccagatgttttgcagcttctcga gcaaatttggcaaatttgccgagctcggca
    Mapping_target: F56A11
    Type_of_mutation: Insertion: ATTTGGCAAATTTGGCAAATTTGCCGGCAAATTTGGCAAATTTGCCTA
      Deletion
    PCR_product: OK1603_external
      OK1603_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00036391
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00001579
    Transcript: F56A11.1.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F56A11.1.1:c.54_388-1270delinsATTTGGCAAATTTGGCAAATTTGCCGGCAAATTTGGCAAATTTGCCTA
        cDNA_position: 61-?
        CDS_position: 54-?
        Protein_position: 18-?
        Intron_number: 3-5/13
        Exon_number: 3-5/14
  Isolation: Mutagen: EMS
  Genetics: Mapping_data: In_multi_point: 5641
  Description: Phenotype: WBPhenotype:0000384 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        Remark: 21% PDE axons failed to reach the VCN or reached it at a >45 angle from the PDE cell body (n=237). Paper_evidence: WBPaper00032090
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006747 PATO:0000460 Paper_evidence: WBPaper00032090
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Phenotypes were scored for maternally rescued progeny. Paper_evidence: WBPaper00032090
              Curator_confirmed: WBPerson712
          Genotype: osm-6::gfp Paper_evidence: WBPaper00032090
              Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        Remark: Animals are slightly Unc. Paper_evidence: WBPaper00032090
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00032907
        Curator_confirmed: WBPerson712
        Remark: Animals are similar in profile to gex-2(tr116), data not shown. Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Paper_evidence: WBPaper00032090
          WBPaper00032907
        Curator_confirmed: WBPerson712
        Remark: Animals are similar in profile to gex-2(tr116), data not shown. Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
      WBPhenotype:0001224 Paper_evidence: WBPaper00032907
        Curator_confirmed: WBPerson712
        Remark: HSN axons are occasionally misguided. These defects can be rescued by HSN-specific expression of GEX-2 driven by the unc-86 promoter. Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00032907
                Curator_confirmed: WBPerson712
      WBPhenotype:0001774 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00032090
                Curator_confirmed: WBPerson712
      WBPhenotype:0001930 Paper_evidence: WBPaper00032907
        Curator_confirmed: WBPerson712
        Remark: Animals display fewer dorsal and ventral muscle arms compared to control animals. These defects can be rescued by muscle-expressed GEX-2. Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000180 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        Remark: 0% axons were prematurely terminated and thickened (n=237). Paper_evidence: WBPaper00032090
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006747 PATO:0000460 Paper_evidence: WBPaper00032090
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Phenotypes were scored for maternally rescued progeny. Paper_evidence: WBPaper00032090
              Curator_confirmed: WBPerson712
      WBPhenotype:0000905 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        Remark: 0% cell bodies and axons displayed a spread morphology or ectopic lamellipodia/filopodia-like structure (n=237). Paper_evidence: WBPaper00032090
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006747 PATO:0000460 Paper_evidence: WBPaper00032090
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Phenotypes were scored for maternally rescued progeny. Paper_evidence: WBPaper00032090
              Curator_confirmed: WBPerson712
      WBPhenotype:0002490 Paper_evidence: WBPaper00032090
        Curator_confirmed: WBPerson712
        Remark: 2% ectopic axon branches emanated from axons that were not misguided (n=237). Paper_evidence: WBPaper00032090
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006747 PATO:0000460 Paper_evidence: WBPaper00032090
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Phenotypes were scored for maternally rescued progeny. Paper_evidence: WBPaper00032090
              Curator_confirmed: WBPerson712
  Reference: WBPaper00032090
    WBPaper00032907
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele