Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00143608

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00143608EvidencePaper_evidenceWBPaper00026941
NamePublic_namee928
Sequence_detailsMapping_targetZK897
Type_of_mutationDeletion
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (11)
LaboratoryCB
ZAS
NCA
StatusLive
AffectsGeneWBGene00006767
InteractorWBInteraction000052071
WBInteraction000052107
WBInteraction000052182
WBInteraction000052339
WBInteraction000504821
WBInteraction000534853
WBInteraction000537564
GeneticsMapping_dataIn_2_point4247
4450
5527
In_multi_point1263
1535
1537
1750
1876
1922
1924
1926
DescriptionPhenotype (15)
Phenotype_not_observedWBPhenotype:0000146Paper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
RemarkAbrupt temperature increases did not impact locomotion rate in unc-31 mutants and wild-type.Paper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
WBPhenotype:0000157Paper_evidenceWBPaper00031426
Curator_confirmedWBPerson712
RemarkAnimals exhibit a normal number of posterior body contractions/cycle (87/87).Paper_evidenceWBPaper00031426
Curator_confirmedWBPerson712
Phenotype_assayTreatmentThe presence or absence of each muscle contraction was scored for 11 defecation cycles in day 1 adults (n 6).Paper_evidenceWBPaper00031426
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00042524
Curator_confirmedWBPerson2987
Remark"In contrast to a loss of unc-13, when the rab-3::xbp-1s strain was crossed with unc-31(e928), we found very little, if any, effect on distal UPR-ER activation or activation in the nervous system (Figures 7B and S6E)."Paper_evidenceWBPaper00042524
Curator_confirmedWBPerson2987
Phenotype_assayGenotyperab-3p::xbp-1s; hsp-4p::GFPPaper_evidenceWBPaper00042524
Curator_confirmedWBPerson2987
WBPhenotype:0000436Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
RemarkLocalization of the synaptic protein SNB-1 is normal, based on expression analysis of SNB-1::VENUS.Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
WBPhenotype:0000623Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
RemarkAcute expression of UNC-31 in unc-31 null mutants after the completion of nervous system development fully rescues the defecation cycle defects in adult mutants.Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Phenotype_assayGenotypeoxIs179[hsp:UNC-31]unc-13(e928)Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
WBPhenotype:0000654Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
RemarkAs assayed by uptake of FM-64 by cultured neurons in depolarization buffer.Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Phenotype_assayGenotypeunc-13(e928) jsIs219 [synaptogyrin::GFP]Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
RemarkLocalization of the pan-neuronal expressed preproANF::GFP is normal.Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
Phenotype_assayGenotypetgIs5[Paex-3:ANF::GFP] unc-13(e928)Paper_evidenceWBPaper00030754
Curator_confirmedWBPerson712
WBPhenotype:0001512Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
RemarkON-OFF asymmetry of ASEL and ASER was preserved in each of these animals.Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
WBPhenotype:0001616Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkTrimethadione significantly extended life-span of mutant animals (N=55)(1 ind.exp.), although to a less extent than observed for WT.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatmentLifespan analysis was performed on animals exposed to 4 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Temperature20CPaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0001617Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkEthosuximide significantly extended life-span of mutant animals (N=95)(3 ind.exp.), as it does for WT animals.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatmentLifespan analysis was performed on animals exposed to 2 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Temperature20CPaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0001800Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
RemarkNormal increase in pnlp-29::GFP expression after infection.Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Phenotype_assayGenotypefrIs7 [pnlp-29::GFP]Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
WBPhenotype:0001818Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
RemarkHSNs showed robust and rhythmic activity.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
GenotypeCameleon IjIs25[myo-3::YC2.0]Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
WBPhenotype:0001838Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
RemarkThe PMA-induced upregulation of pnlp-29::GFP expression was normal in mutant wormsPaper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Phenotype_assayGenotypefrIs7 [pnlp-29::GFP]Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
WBPhenotype:0001840Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
RemarkNormal increase in pnlp-29::GFP expression after woundingPaper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Phenotype_assayGenotypefrIs7 [pnlp-29::GFP]Paper_evidenceWBPaper00033094
Curator_confirmedWBPerson2021
Reference (34)
RemarkThe region deleted by the unc-31(e928) mutation, includes the entire C-terminal half of UNC-31 (553-1260 of 1260 aa total).Paper_evidenceWBPaper00026941
MethodDeletion_allele