WormBase Tree Display for Variation: WBVar00143608
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WBVar00143608 | Evidence | Paper_evidence | WBPaper00026941 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | e928 | |||||||
Sequence_details | Mapping_target | ZK897 | |||||||
Type_of_mutation | Deletion | ||||||||
SeqStatus | Pending_curation | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain (11) | |||||||||
Laboratory | CB | ||||||||
ZAS | |||||||||
NCA | |||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00006767 | |||||||
Interactor | WBInteraction000052071 | ||||||||
WBInteraction000052107 | |||||||||
WBInteraction000052182 | |||||||||
WBInteraction000052339 | |||||||||
WBInteraction000504821 | |||||||||
WBInteraction000534853 | |||||||||
WBInteraction000537564 | |||||||||
Genetics | Mapping_data | In_2_point | 4247 | ||||||
4450 | |||||||||
5527 | |||||||||
In_multi_point | 1263 | ||||||||
1535 | |||||||||
1537 | |||||||||
1750 | |||||||||
1876 | |||||||||
1922 | |||||||||
1924 | |||||||||
1926 | |||||||||
Description | Phenotype (15) | ||||||||
Phenotype_not_observed | WBPhenotype:0000146 | Paper_evidence | WBPaper00032087 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Abrupt temperature increases did not impact locomotion rate in unc-31 mutants and wild-type. | Paper_evidence | WBPaper00032087 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032087 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000157 | Paper_evidence | WBPaper00031426 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibit a normal number of posterior body contractions/cycle (87/87). | Paper_evidence | WBPaper00031426 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | The presence or absence of each muscle contraction was scored for 11 defecation cycles in day 1 adults (n 6). | Paper_evidence | WBPaper00031426 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000306 | Paper_evidence | WBPaper00042524 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "In contrast to a loss of unc-13, when the rab-3::xbp-1s strain was crossed with unc-31(e928), we found very little, if any, effect on distal UPR-ER activation or activation in the nervous system (Figures 7B and S6E)." | Paper_evidence | WBPaper00042524 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | rab-3p::xbp-1s; hsp-4p::GFP | Paper_evidence | WBPaper00042524 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000436 | Paper_evidence | WBPaper00028886 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Remark | Localization of the synaptic protein SNB-1 is normal, based on expression analysis of SNB-1::VENUS. | Paper_evidence | WBPaper00028886 | ||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0000623 | Paper_evidence | WBPaper00030754 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Acute expression of UNC-31 in unc-31 null mutants after the completion of nervous system development fully rescues the defecation cycle defects in adult mutants. | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Genotype | oxIs179[hsp:UNC-31]unc-13(e928) | Paper_evidence | WBPaper00030754 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000654 | Paper_evidence | WBPaper00030754 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | As assayed by uptake of FM-64 by cultured neurons in depolarization buffer. | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Genotype | unc-13(e928) jsIs219 [synaptogyrin::GFP] | Paper_evidence | WBPaper00030754 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000679 | Paper_evidence | WBPaper00030754 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Localization of the pan-neuronal expressed preproANF::GFP is normal. | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00030754 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Genotype | tgIs5[Paex-3:ANF::GFP] unc-13(e928) | Paper_evidence | WBPaper00030754 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001512 | Paper_evidence | WBPaper00031992 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | ON-OFF asymmetry of ASEL and ASER was preserved in each of these animals. | Paper_evidence | WBPaper00031992 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001616 | Paper_evidence | WBPaper00024698 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Trimethadione significantly extended life-span of mutant animals (N=55)(1 ind.exp.), although to a less extent than observed for WT. | Paper_evidence | WBPaper00024698 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Lifespan analysis was performed on animals exposed to 4 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50. | Paper_evidence | WBPaper00024698 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature | 20C | Paper_evidence | WBPaper00024698 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001617 | Paper_evidence | WBPaper00024698 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Ethosuximide significantly extended life-span of mutant animals (N=95)(3 ind.exp.), as it does for WT animals. | Paper_evidence | WBPaper00024698 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Lifespan analysis was performed on animals exposed to 2 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50. | Paper_evidence | WBPaper00024698 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature | 20C | Paper_evidence | WBPaper00024698 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001800 | Paper_evidence | WBPaper00033094 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Normal increase in pnlp-29::GFP expression after infection. | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001818 | Paper_evidence | WBPaper00032221 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | HSNs showed robust and rhythmic activity. | Paper_evidence | WBPaper00032221 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032221 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00032221 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C. | Paper_evidence | WBPaper00032221 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Genotype | Cameleon IjIs25[myo-3::YC2.0] | Paper_evidence | WBPaper00032221 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001838 | Paper_evidence | WBPaper00033094 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | The PMA-induced upregulation of pnlp-29::GFP expression was normal in mutant worms | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001840 | Paper_evidence | WBPaper00033094 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Normal increase in pnlp-29::GFP expression after wounding | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Reference (34) | |||||||||
Remark | The region deleted by the unc-31(e928) mutation, includes the entire C-terminal half of UNC-31 (553-1260 of 1260 aa total). | Paper_evidence | WBPaper00026941 | ||||||
Method | Deletion_allele |