WormBase Tree Display for Variation: WBVar00145247
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WBVar00145247 | Name | Public_name | ev554 | ||||||
---|---|---|---|---|---|---|---|---|---|
Sequence_details | Mapping_target | C53D6 | |||||||
Type_of_mutation | Substitution | ||||||||
SeqStatus | Pending_curation | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00029121 | ||||||||
Laboratory | NW | ||||||||
Status | Live | ||||||||
Affects (2) | |||||||||
Genetics | Map | IV | Position | 4.1 | |||||
Mapping_data | In_multi_point | 3431 | |||||||
3432 | |||||||||
3433 | |||||||||
4057 | |||||||||
4058 | |||||||||
Description | Phenotype | WBPhenotype:0000002 | Person_evidence | WBPerson261 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | variable kinker | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000181 | Paper_evidence | WBPaper00031671 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | The dorsal and subventral processes of the NSM neurons showed a variety of initiation and termination defects that affected 43% of NSM neurons | Paper_evidence | WBPaper00031671 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00031671 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0003666 | PATO:0000460 | Paper_evidence | WBPaper00031671 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Genotype | zdIs13 [ tph-1p::GFP] | Paper_evidence | WBPaper00031671 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000195 | Paper_evidence | WBPaper00005809 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "In their respective double mutants with the hypomorph unc-5(e152), both unc-129 and dbl-1 mutations, but not other mutants tested, caused significant increases in the frequency of DTC migration defects compared with unc-5(e152) alone (Table 3)... The double mutant unc-5(e152) unc-129(ev554) was significantly different from unc-5(e152) in the frequency of anterior (P < 0.005) but not posterior (P > 0.08) DTC defects." | Paper_evidence | WBPaper00005809 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
"The double mutant unc-5(e53) unc-129(ev554) exhibited a small but significant (P < 0.02) reduction in the frequency of anterior DTC migration defects (Table 3)." | Paper_evidence | WBPaper00005809 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00005809 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006865 | PATO:0000460 | Paper_evidence | WBPaper00005809 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
GO_term | GO:0016477 | PATO:0000460 | Paper_evidence | WBPaper00005809 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | unc-5(e152) | Paper_evidence | WBPaper00005809 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
unc-5(e53) | Paper_evidence | WBPaper00005809 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000384 | Paper_evidence | WBPaper00032163 | |||||||
WBPaper00040335 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPerson7190 | |||||||||
Remark | Half of animals exhibited DA9 axon guidance defects. | Paper_evidence | WBPaper00032163 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005303 | PATO:0000460 | Paper_evidence | WBPaper00032163 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005270 | PATO:0000460 | Paper_evidence | WBPaper00032163 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | 25 | Paper_evidence | WBPaper00032163 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Genotype | unc-5::intron::unc-5 | Paper_evidence | WBPaper00032163 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000643 | Paper_evidence | WBPaper00040335 | |||||||
Person_evidence | WBPerson261 | ||||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPerson7190 | |||||||||
Remark | uncoordinated | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001224 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | axons grow in aberrant directions | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000845 | Paper_evidence | WBPaper00034730 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants had normal sensitivity to cholinergic agonists | Paper_evidence | WBPaper00034730 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Affected_by | Molecule | WBMol:00004019 | Paper_evidence | WBPaper00034730 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000847 | Paper_evidence | WBPaper00032163 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | RAB-3::GFP was not observed to be mislocalized to dendrites. | Paper_evidence | WBPaper00032163 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0004857 | PATO:0000460 | Paper_evidence | WBPaper00032163 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001573 | Paper_evidence | WBPaper00034730 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants had normal sensitivity to cholinergic agonists | Paper_evidence | WBPaper00034730 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001652 | Paper_evidence | WBPaper00032446 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Reference | WBPaper00040335 | ||||||||
WBPaper00031671 | |||||||||
WBPaper00034730 | |||||||||
WBPaper00032446 | |||||||||
WBPaper00025979 | |||||||||
WBPaper00005809 | |||||||||
WBPaper00018953 | |||||||||
WBPaper00032163 | |||||||||
Remark | Molecular change reported to be D327 to Stop. | Paper_evidence | WBPaper00003139 | ||||||
Method | Substitution_allele |