Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00145642

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00145642NamePublic_namegk235
Other_nameC08A9.1.1:c.54-167_228delinsATCTAA
HGVSgCHROMOSOME_X:g.17093068_17093457delinsATCTAA
Sequence_detailsSMapS_parentSequenceC08A9
Flanking_sequencesgaaaatatctaggaaatactacttttaaaaaatctaaaagaagcaattgctctccaacca
Mapping_targetC08A9
Type_of_mutationInsertionATCTAA
Deletion
PCR_productgk235_external
gk235_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000204
WBStrain00035766
LaboratoryVC
PersonWBPerson427
KO_consortium_allele
StatusLive
AffectsGeneWBGene00015583
WBGene00004932
TranscriptC08A9.1.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScC08A9.1.1:c.54-167_228delinsATCTAA
cDNA_position?-243
CDS_position?-228
Protein_position?-76
Intron_number2-3/6
Exon_number3-4/7
C08A9.3a.1VEP_consequencesplice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number2/16
Exon_number1-2/17
InteractorWBInteraction000542786
WBInteraction000542787
IsolationMutagenTMP/UV
GeneticsMapping_dataIn_multi_point4685
DescriptionPhenotypeWBPhenotype:0000136Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
RemarkThe sod-3(gk235) mutation resulted in increased induction of mRNA expression of the genes hsp-16.1, hsp-16.2, hsp-16.41, hsp-70, col-131, pgp-14, ain-1, apt-10, lin-10, cogc-4, wnk-1, and F02A9.4 in response to silver nanoparticle (AgNP) exposure, compared to wild type animals and as determined by qRT-PCR. Also, mtl-2 expression was absent (Figure 4 compared to Figure 3A).Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00005288Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
WBPhenotype:0000591Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
Remarksod-3(gk235) mutants exhibited a significant resistance to the toxic effects of silver nanoparticles on reproduction (Table 1)Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00005288Paper_evidenceWBPaper00034661
Curator_confirmedWBPerson2987
WBPhenotype:0001014Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
RemarkThis mutant is more resistant to enterotoxigenic Escherichia coli infection compared with N2 wild-type animals.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals grown on plates containing K88plus enterotoxigenic Escherichia coli (ETEC) strain JG280.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
WBPhenotype:0001224Paper_evidenceWBPaper00031981
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006976PATO:0000460Paper_evidenceWBPaper00031981
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown under hypoxic (1% oxygen) conditions.Paper_evidenceWBPaper00031981
Curator_confirmedWBPerson712
WBPhenotype:0002125Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
RemarkExposure to only a selected coated silver nanoparticles (Ag NPs), PVP38, CIT7, and GA22 resulted in an enhanced level of growth inhibition compared to similarly treated N2; however, exposure to AgNO3, PVP8, and GA5 did not result in an enhanced response.Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005288Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00005290Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00005293Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00005294Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00005295Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00005296Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBMol:00003522Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson712
WBPhenotype:0002251Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
RemarkExposure to only a selected coated silver nanoparticles (Ag NPs), PVP38, CIT7, and GA22 resulted in an enhanced level of growth inhibition compared to similarly treated N2; however, exposure to AgNO3, PVP8, and GA5 did not result in an enhanced response.Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
Affected_byMoleculeWBMol:00005288Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00005290Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00005293Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00005294Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00005295Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00005296Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBMol:00003522Paper_evidenceWBPaper00040519
Curator_confirmedWBPerson557
WBPhenotype:0002256Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
RemarkResistant to selenium induced movement defect.Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00001915Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0001379Paper_evidenceWBPaper00044243
Curator_confirmedWBPerson3701
Remarknot more sensitive than wildtype to toxicity from exposure to water or pore water from sediments downstream of mountaintop mining sites (data not shown)Paper_evidenceWBPaper00044243
Curator_confirmedWBPerson3701
ReferenceWBPaper00040519
WBPaper00034661
WBPaper00031981
WBPaper00044243
WBPaper00044686
WBPaper00055320
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele