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WormBase Tree Display for Variation: WBVar00266627

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Name Class

WBVar00266627EvidencePaper_evidenceWBPaper00005356
NamePublic_nameu265
Other_nameCE17128:p.Leu46Phe
F57H12.7a.1:c.136C>T
HGVSgCHROMOSOME_IV:g.7985580G>A
Sequence_detailsSMapS_parentSequenceF57H12
Flanking_sequencesgataatcttgctaaactctcagctcattgcttcagcttcgtactcctttgacaacttgtg
Mapping_targetF57H12
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00005356
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00035038
LaboratoryTU
StatusLive
AffectsGeneWBGene00003178
TranscriptF57H12.7a.1 (12)
GeneticsInterpolated_map_positionIV3.57035
Mapping_dataIn_multi_point1114
1115
1116
1117
2067
2068
In_pos_neg_data2727
DescriptionPhenotypeWBPhenotype:0000315Paper_evidenceWBPaper00001125
Curator_confirmedWBPerson712
RemarkAnimals are touch sensitive as newly hatched larva but become insensitive as they mature.Paper_evidenceWBPaper00001125
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00001125
Curator_confirmedWBPerson712
WBPhenotype:0000456Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarklarvae touch sensitive, older animals touch insensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000041PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001224Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
RemarkALM and PLM axons in late larvae and young adults were often curved and had apparently swollen regions (Figure 2A; Figure S2A) and infrequent ectopic branches that appeared to derive from the swollen regions (Figure S2A). mec-17(u265) produced an increase in the length of the TRN processes (Figure 2B; Figure S2B). The most dramatic increase was seen in the length of a normally short, or nonexistent, ALM posterior process (Figure 2B). Both the anterior processes of the ALM neurons and the anterior and the posterior processes of the PLM neurons were longer in the mec-17 mutant strains (Figure 2B; Figure S2B)Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
WBbt:0005490PATO:0000460Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
Life_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
WBls:0000041PATO:0000460Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
GO_termGO:0007409PATO:0000460Paper_evidenceWBPaper00041152
Curator_confirmedWBPerson9270
WBPhenotype:0001278Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkmec-3:lacZ expression not maintained in touch cellsPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0002364Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
RemarkSpontaneous axon degeneration in adult animals, predominantly affecting PLM, but also ALM and AVM to a lessor degree (Data not shown)Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
EQ_annotationsAnatomy_termWBbt:0005490PATO:0000460Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
WBbt:0005406PATO:0000460Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00044649
Curator_confirmedWBPerson9270
ReferenceWBPaper00041152
WBPaper00005356
WBPaper00001125
WBPaper00017610
WBPaper00010978
WBPaper00044649
RemarkIn addition to the lesion curated, u265 also causes a D72G (gat-ggt) mutation with flanks of attcaactttatatctctcttggaaatatg & tgagtaagttaatattcttattcatatactPaper_evidenceWBPaper00005356
MethodSubstitution_allele