WormBase Tree Display for Gene: WBGene00004346

WBGene00004346 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: rgs-3 Person_evidence: WBPerson330
      Sequence_name: C29H12.3
      Molecular_name (13)
      Other_name: CELE_C29H12.3 Accession_evidence: NDB BX284602
      Public_name: rgs-3
    DB_info: Database: AceView gene 2G399
        WormQTL gene WBGene00004346
        WormFlux gene WBGene00004346
        NDB locus_tag CELE_C29H12.3
        Panther gene CAEEL|WormBase=WBGene00004346|UniProtKB=Q18312
          family PTHR10845
        NCBI gene 174020
        RefSeq protein NM_062822.4
            NM_001393090.1
            NM_182096.6
        SwissProt UniProtAcc Q18312
        TrEMBL UniProtAcc Q5DX43
            Q8MQB2
        UniProt_GCRP UniProtAcc Q18312
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rgs
    Allele: WBVar00736095
      WBVar00736096
      WBVar00736097
      WBVar01499702
      WBVar00736098
      WBVar00736099
      WBVar00736100
      WBVar00736101
      WBVar00736102
      WBVar00736103
      WBVar00736104
      WBVar01576940
      WBVar00736105
      WBVar01249773
      WBVar01498435
      WBVar00093448
      WBVar01492749
      WBVar01626591
      WBVar00224956
      WBVar01783584
      WBVar01783585
      WBVar01783586
      WBVar01783587
      WBVar01783588
      WBVar01499042
      WBVar01499043
      WBVar01373744
      WBVar00251460
      WBVar00550809
      WBVar01493365
      WBVar00314501
      WBVar00172476
      WBVar00172477
      WBVar00172478
      WBVar00172479
      WBVar00172480
      WBVar00172481
      WBVar00172482
      WBVar00172483
      WBVar00172484
      WBVar00367524
      WBVar00367525
      WBVar00367526
      WBVar00367527
      WBVar00367528
      WBVar00367529
      WBVar00367530
      WBVar00367531
      WBVar00736053
      WBVar00367532
      WBVar00736054
      WBVar00736055
      WBVar00367533
      WBVar00736056
      WBVar00367534
      WBVar00367535
      WBVar00736057
      WBVar00367536
      WBVar00736058
      WBVar00736059
      WBVar00367537
      WBVar00736060
      WBVar00367538
      WBVar00736061
      WBVar00367539
      WBVar00736062
      WBVar00367540
      WBVar01604000
      WBVar00736063
      WBVar00367541
      WBVar00367542
      WBVar00262011
      WBVar00736064
      WBVar00367543
      WBVar00736065
      WBVar00736066
      WBVar00367544
      WBVar00736067
      WBVar00367545
      WBVar00736068
      WBVar00367546
      WBVar00736069
      WBVar00367547
      WBVar00275065
      WBVar00736070
      WBVar01960044
      WBVar00736071
      WBVar00736073
      WBVar00736074
      WBVar01720072
      WBVar00736075
      WBVar01720073
      WBVar01720074
      WBVar00736076
      WBVar00736077
      WBVar01720075
      WBVar00736078
      WBVar00736079
      WBVar00736080
      WBVar00736081
      WBVar00736082
      WBVar00736083
      WBVar00736084
      WBVar00736085
      WBVar00736086
      WBVar00736087
      WBVar00736088
      WBVar00736089
      WBVar00736090
      WBVar02018000
      WBVar00736091
      WBVar00736092
      WBVar00736093
      WBVar00736094
    Strain: WBStrain00026361
      WBStrain00032471
    RNASeq_FPKM (74)
    GO_annotation: 00060895
      00060896
      00060897
      00060898
      00060899
      00060900
      00060901
    Ortholog (28)
    Paralog: WBGene00004344 Caenorhabditis elegans From_analysis: Panther
      WBGene00004345 Caenorhabditis elegans From_analysis: Panther
      WBGene00004350 Caenorhabditis elegans From_analysis: Panther
      WBGene00004347 Caenorhabditis elegans From_analysis: Panther
      WBGene00004354 Caenorhabditis elegans From_analysis: Panther
      WBGene00004353 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: rgs-3 encodes three proteins containing two RGS (regulator of G protein signaling) domains, the more C-terminal of which is most similar to those of the mammalian brain-specific RGS, RGS8; rgs-3 activity is required for normal G protein-mediated response to a number of sensory stimuli, including odorants, high osmolarity, and nose touch off food; genetic analyses indicate that RGS-3 functions to decrease G protein signaling in sensory neurons and increase glutamatergic synaptic transmission from sensory to interneurons; RGS-3::GFP fusion proteins are expressed exclusively in nine pairs of sensory neurons from late stages of embryogenesis through adulthood. Paper_evidence: WBPaper00028963
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 24 Apr 2007 00:00:00
      Automated_description: Involved in chemosensory behavior and sensory perception of bitter taste. Expressed in amphid neurons and phasmid neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C29H12.3a
      C29H12.3b
      C29H12.3c
    Corresponding_transcript: C29H12.3a.1
      C29H12.3a.2
      C29H12.3b.1
      C29H12.3b.2
      C29H12.3c.1
      C29H12.3c.2
      C29H12.3c.3
    Other_sequence (24)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00011368 Inferred_automatically: RNAi_primary
      WBRNAi00000844 Inferred_automatically: RNAi_primary
      WBRNAi00041511 Inferred_automatically: RNAi_primary
      WBRNAi00029341 Inferred_automatically: RNAi_primary
      WBRNAi00065514 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2043
      Expr4511
      Expr1024036
      Expr1032164
      Expr1145535
      Expr2015326
      Expr2033560
    Drives_construct: WBCnstr00012069
      WBCnstr00035550
    Construct_product: WBCnstr00007781
      WBCnstr00012069
      WBCnstr00035550
    Microarray_results (35)
    Expression_cluster: WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055648:male-CEM-neurons_expressed
      WBPaper00055648:male-tail_expressed
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056826:hmc_biased
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADF
      WBPaper00061340:ADL
      WBPaper00061340:ASE
      WBPaper00061340:ASG
      WBPaper00061340:ASH
      WBPaper00061340:ASI
      WBPaper00061340:ASJ
      WBPaper00061340:ASK
      WBPaper00061340:AWA
      WBPaper00061340:AWB
      WBPaper00061340:AWC
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061651:ADF_enriched
      WBPaper00061651:ADL_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:ASI_enriched
      WBPaper00061651:ASJ_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:AWB_enriched
      WBPaper00061651:AWC_OFF_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00061651:PHB_enriched
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:111
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065841:63_0
      WBPaper00065841:77_0
      WBPaper00065841:99_0
      WBPaper00065841:101_0
      cgc4386_cluster_5_1
      cgc4489_group_18
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045294:0.1uM_TBBP_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:N2_allantoin_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(23_min)
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MDET
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction: WBInteraction000361960
      WBInteraction000368226
      WBInteraction000418318
      WBInteraction000423849
      WBInteraction000569525
      WBInteraction000569527
  Map_info: Map: II Position: -0.485213 Error: 0.010992
    Positive: Positive_clone: C29H12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4907
        4305
        5045
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene