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WormBase Tree Display for Gene: WBGene00004879

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Name Class

WBGene00004879SMapS_parentSequenceC48B6
IdentityVersion1
NameCGC_namesmg-1Person_evidenceWBPerson261
Sequence_nameC48B6.6
Molecular_nameC48B6.6a
C48B6.6a.1
CE30258
C48B6.6b
CE53740
C48B6.6b.1
Other_namemab-1
CELE_C48B6.6Accession_evidenceNDBBX284601
Public_namesmg-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsmg
Reference_alleleWBVar00143847
AlleleWBVar00051557Inferred_automatically (11)
WBVar00051552Inferred_automaticallyFrom strain object: PD8117
From strain object: PD8119
WBVar02147714Inferred_automaticallyFrom strain object: RM969
WBVar00241392Inferred_automaticallyFrom strain object: TR1331
WBVar00241427Inferred_automaticallyFrom strain object: TR1417
WBVar00088771
WBVar00241408
WBVar00241404
WBVar00144683
WBVar00088772
WBVar00241414
WBVar00241422
WBVar00241407
WBVar00241395
WBVar00241417
WBVar00241412
WBVar00143851
WBVar00241409
WBVar00241377
WBVar00144588
WBVar00241418
WBVar00241402
WBVar00241420
WBVar00241416
WBVar00088769
WBVar00241425
WBVar00646577
WBVar00646578
WBVar00646579
WBVar00646580
WBVar00646581
WBVar00646582
WBVar00646583
WBVar00646584
WBVar00646585
WBVar00646586
WBVar00646587
WBVar00646588
WBVar00646589
WBVar00646590
WBVar00646591
WBVar00646592
WBVar00646593
WBVar00646594
WBVar00646595
WBVar00646596
WBVar00646597
WBVar00646598
WBVar00646599
WBVar00646600
WBVar00646601
WBVar00646602
WBVar00646603
WBVar00646604
WBVar00646605
WBVar00646606
WBVar00646607
WBVar00646608
WBVar00646609
WBVar00321339
WBVar00646610
WBVar00646611
WBVar00241413
WBVar00241430
WBVar00241432
WBVar00267087
WBVar02109599
WBVar02148545
WBVar00241498
WBVar01475668
WBVar01411649
WBVar01475669
WBVar00143847
WBVar01499786
WBVar01499054
WBVar02039706
WBVar00337146
WBVar00337147
WBVar01431991
WBVar00337148
WBVar01431992
WBVar00337149
WBVar01431993
WBVar00337150
WBVar01431994
WBVar00337151
WBVar00337152
WBVar01431995
WBVar00337153
WBVar01431996
WBVar00337154
WBVar01431997
WBVar00319506
WBVar00337155
WBVar02127728
WBVar00337156
WBVar00337157
WBVar02127729
WBVar00337158
WBVar00337159
WBVar00337160
WBVar00337161
WBVar00337162
WBVar00337163
WBVar00337164
WBVar00337165
WBVar00337166
WBVar00337167
WBVar00000640
WBVar01283379
WBVar01283380
WBVar00646546
WBVar00646547
WBVar00646548
WBVar00646549
WBVar00646550
WBVar00646551
WBVar00646552
WBVar00646553
WBVar00646554
WBVar00646555
WBVar00646556
WBVar00646557
WBVar00646558
WBVar00646559
WBVar00646560
WBVar00646561
WBVar00646562
WBVar00646563
WBVar00646564
WBVar00646565
WBVar00646566
WBVar00646567
WBVar00646568
WBVar00646569
WBVar01909723
WBVar00646570
WBVar01909724
WBVar00317637
WBVar00646571
WBVar00249875
WBVar01498959
WBVar00646572
WBVar00646573
WBVar00646574
WBVar00646575
WBVar00646576
Legacy_informatione1228 : adult male has swollen bursa ES3 (adult male) ME1. Adult hermaphrodite has protruding vulva. ES2. NA4 (e1233 e2134spo : similar phenotype).
See also e1228, e1229, e1233, e2134, e2263, ma127, ma129, ma131
[C.elegansII] e1228 : adult male has swollen bursa.ES3 (adult male) ME1. Adult hermaphrodite has protruding vulva. ES2. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate.OA>10: e1233, e2134spo (similar phenotypes), ma127, ma131, r861, r913spo, etc. Cloned: 7.8 kb transcript, encodes predicted protein with some kinase similarity in C-term. [Hodgkin et al. 1989; Pulak and Anderson 1993; TR]
Complementation_data[Pulak R] complements n2088
Strain (23)
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (36)
Paralog (4)
Structured_descriptionConcise_descriptionsmg-1 encodes a phosphatidylinositol kinase-related protein kinase; SMG-1 functions as a key component of the nonsense-mediated mRNA decay (NMD) pathway that identifies and degrades mRNAs that contain premature stop codons; in addition, and partially in parallel to DAF-2-insulin signaling, SMG-1 regulates adult lifespan and the response to oxidative stress; in vitro, SMG-1 is capable of phosphorylating SMG-2/UPF1, an RNA helicase whose activity is also required for NMD and with which SMG-1 coimmunoprecipitates from crude extracts.Paper_evidenceWBPaper00024418
WBPaper00032237
Curator_confirmedWBPerson1843
Date_last_updated07 Oct 2008 00:00:00
Automated_descriptionPredicted to enable protein serine/threonine kinase activity. Involved in male genitalia development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and obsolete hermaphrodite genitalia development. Predicted to be located in nucleus. Predicted to be part of TORC1 complex and TORC2 complex. Is an ortholog of human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC48B6.6a
C48B6.6b
Corresponding_CDS_historyC48B6.6:wp126
C48B6.6b:wp273
Corresponding_transcriptC48B6.6a.1
C48B6.6b.1
Other_sequence (18)
Associated_featureWBsf664370
WBsf664371
WBsf664372
WBsf664373
WBsf984028
WBsf1010005
WBsf219650
WBsf219651
Experimental_infoRNAi_result (20)
Expr_patternExpr1024290
Expr1032418
Expr1146716
Expr2015907
Expr2034140
Construct_productWBCnstr00007260
Regulate_expr_clusterWBPaper00053308:NMD(-)_downregulated_SMD-2_non-binding_ClassIV
WBPaper00053308:NMD(-)_upregulated_SMD-2_non-binding_ClassIII
AntibodyWBAntibody00000757
WBAntibody00002206
Microarray_results (29)
Expression_cluster (93)
Interaction (70)
Map_infoMapIPosition1.48161Error0.009583
Well_ordered
PositivePositive_cloneC48B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
F56F2
Mapping_data2_point328
Multi_point204
1889
1890
2089
5509
Reference (133)
Remark[Pulak R] n2088 may be a deficiency, nDf48
Sequence connection from [O'Connor SL, Anderson RP] based on EMBL:AF149821
MethodGene