WormBase Tree Display for Gene: WBGene00001006

WBGene00001006 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C25F6
  Identity: Version: 1
    Name: CGC_name: dlg-1
      Sequence_name: C25F6.2
      Molecular_name: C25F6.2
        C25F6.2.1
        CE36524
      Other_name: CELE_C25F6.2 Accession_evidence: NDB BX284606
      Public_name: dlg-1
    DB_info: Database: AceView gene XG103
        WormQTL gene WBGene00001006
        WormFlux gene WBGene00001006
        NDB locus_tag CELE_C25F6.2
        Panther gene CAEEL|WormBase=WBGene00001006|UniProtKB=G5ECY0
          family PTHR23119
        NCBI gene 180819
        RefSeq protein NM_001029260.5
        SwissProt UniProtAcc G5ECY0
        UniProt_GCRP UniProtAcc G5ECY0
        OMIM gene 300189
            602887
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dlg
    Allele: WBVar00091616 Inferred_automatically: From strain object: SD1135
      WBVar02158023
      WBVar02158361
      WBVar02158373
      WBVar01147709
      WBVar01147710
      WBVar01147711
      WBVar01147712
      WBVar01758429
      WBVar01147713
      WBVar01758430
      WBVar01758431
      WBVar01147714
      WBVar01147715
      WBVar01147716
      WBVar01147717
      WBVar01147718
      WBVar01147719
      WBVar01147720
      WBVar01147721
      WBVar01147722
      WBVar01147723
      WBVar01147724
      WBVar01147725
      WBVar01147726
      WBVar01147727
      WBVar01879437
      WBVar01879438
      WBVar01147728
      WBVar01147729
      WBVar01879439
      WBVar01147730
      WBVar01879440
      WBVar01147731
      WBVar01879441
      WBVar01147732
      WBVar01879442
      WBVar01879443
      WBVar01147733
      WBVar01879444
      WBVar01147734
      WBVar01879445
      WBVar01147735
      WBVar01879446
      WBVar01147736
      WBVar01147737
      WBVar01879447
      WBVar01147738
      WBVar01819932
      WBVar01819933
      WBVar01819934
      WBVar01819935
      WBVar01819936
      WBVar01830544
      WBVar02063843
      WBVar01549933
      WBVar02063844
      WBVar01549934
      WBVar01549935
      WBVar01549936
      WBVar00503857
      WBVar00503858
      WBVar00503859
      WBVar00503860
      WBVar00503861
      WBVar00503862
      WBVar00503863
      WBVar00503864
      WBVar00503865
      WBVar00503866
      WBVar00503867
      WBVar00503868
      WBVar00503869
      WBVar00503870
      WBVar00503871
      WBVar00503872
      WBVar00503873
      WBVar00503874
      WBVar00503875
      WBVar00503876
      WBVar00503877
      WBVar00503878
      WBVar01945428
      WBVar00079119
      WBVar00079120
      WBVar00079121
      WBVar00079122
      WBVar00079123
      WBVar00275910
      WBVar01147688
      WBVar01147689
      WBVar01147690
      WBVar01147691
      WBVar01147692
      WBVar01147693
      WBVar00599111
      WBVar01147694
      WBVar01147695
      WBVar01147696
      WBVar01147697
      WBVar01147698
      WBVar01147699
      WBVar01147700
      WBVar01147701
      WBVar01147702
      WBVar01147703
      WBVar01147704
      WBVar01147705
      WBVar01147706
      WBVar01147707
      WBVar01500067
      WBVar01147708
    Possibly_affected_by: WBVar02153212
    Strain: WBStrain00007529
      WBStrain00033917
      WBStrain00024324
      WBStrain00026592
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog: WBGene00051667 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035111 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00160686 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00124018 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00230534 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g11781 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g11865 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8774 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g13300 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g10548 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g2521 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g9076 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g136 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9463 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21649 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g17653 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00024.g1481 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_22777.g26912 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-dlg-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold626.g6622 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00154.g5787 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00499 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024430 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g13229 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g21202 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g4213 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0238800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19081 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00240189 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00116813 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259532 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00263585 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285542 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0001624 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-010724-8 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040628-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050221-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050222-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050208-93 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2900 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2901 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:2902 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2903 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:107231 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1277959 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1344351 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1888986 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2505 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:68424 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:68423 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:619895 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00011890 Caenorhabditis elegans From_analysis: Panther
      WBGene00017741 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: dlg-1 encodes a MAGUK protein, orthologous to Drosophila Discs large; DLG-1 is physically located at apical adherens junctions in all epithelia and is required for organization of the embryonic gut epithelium into a coherent tube. Paper_evidence: WBPaper00004424
            WBPaper00004510
            WBPaper00006400
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 27 Jan 2012 00:00:00
      Automated_description: Predicted to enable guanylate kinase activity. Involved in embryo development and zonula adherens assembly. Located in adherens junction and apical junction complex. Expressed in several structures, including arcade cell; germ line; intestine; pharyngeal cell; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; cervix uteri carcinoma in situ; intellectual disability (multiple); and invasive ductal carcinoma. Is an ortholog of human DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2903)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2903)
      DOID:8991 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2900)
      DOID:3008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2900)
      DOID:0112041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2902)
  Molecular_info: Corresponding_CDS: C25F6.2
    Corresponding_CDS_history: C25F6.2a:wp121
      C25F6.2b:wp271
    Corresponding_transcript: C25F6.2.1
    Other_sequence (86)
    Associated_feature (29)
  Experimental_info: RNAi_result (34)
    Expr_pattern (15)
    Drives_construct (17)
    Construct_product: WBCnstr00000944
      WBCnstr00006155
      WBCnstr00007873
      WBCnstr00010311
      WBCnstr00010468
      WBCnstr00015686
      WBCnstr00020203
      WBCnstr00020897
      WBCnstr00037145
      WBCnstr00042006
    Antibody: WBAntibody00000342
      WBAntibody00000426
      WBAntibody00000715
      WBAntibody00000716
      WBAntibody00000993
      WBAntibody00001401
      WBAntibody00001716
      WBAntibody00001732
      WBAntibody00002172
      WBAntibody00002424
    Microarray_results (27)
    Expression_cluster (219)
    Interaction (1194)
  Map_info: Map: X Position: -5.25173 Error: 0.010511
    Positive: Positive_clone: C25F6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4261
        4449
    Pseudo_map_position
  Reference (97)
  Remark: Sequence connection from [Bossinger O]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene