WormBase Tree Display for Gene: WBGene00002232
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WBGene00002232 | SMap | S_parent | Sequence | F11A6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | kpc-1 | Person_evidence | WBPerson533 | |||||
Sequence_name | F11A6.1 | ||||||||
Molecular_name | F11A6.1a | ||||||||
F11A6.1a.1 | |||||||||
CE17653 | |||||||||
F11A6.1a.2 | |||||||||
F11A6.1b | |||||||||
Other_name | CELE_F11A6.1 | Accession_evidence | NDB | BX284601 | |||||
Public_name | kpc-1 | ||||||||
DB_info | Database | AceView | gene | 1M271 | |||||
WormQTL | gene | WBGene00002232 | |||||||
SignaLink | protein | WBGene00002232 | |||||||
WormFlux | gene | WBGene00002232 | |||||||
NDB | locus_tag | CELE_F11A6.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00002232|UniProtKB=O17798 | |||||||
family | PTHR42884 | ||||||||
NCBI | gene | 173051 | |||||||
RefSeq | protein | NM_060573.6 | |||||||
NR_132618.1 | |||||||||
KEGG | KEGG_id | 3.4.21.- | |||||||
NemaPath | KEGG_id | 3.4.21.- | |||||||
SwissProt | UniProtAcc | O17798 | |||||||
UniProt_GCRP | UniProtAcc | O17798 | |||||||
RNAcentral | URSid | URS0000838141 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | kpc | ||||||||
Allele (115) | |||||||||
Strain | WBStrain00035504 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (48) | |||||||||
Ortholog (49) | |||||||||
Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | |||||
WBPaper00018607 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | ||||
DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | ||||||
DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | ||||||
Molecular_info | Corresponding_CDS | F11A6.1a | |||||||
Corresponding_CDS_history | F11A6.1b:wp245 | ||||||||
Corresponding_transcript (3) | |||||||||
Other_sequence (36) | |||||||||
Associated_feature (22) | |||||||||
Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003363 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089035 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106792 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00044358 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027714 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr11217 | ||||||||
Expr11218 | |||||||||
Expr11700 | |||||||||
Expr11982 | |||||||||
Expr13509 | |||||||||
Expr16429 | |||||||||
Expr1014780 | |||||||||
Expr1031309 | |||||||||
Expr1148297 | |||||||||
Expr2012975 | |||||||||
Expr2031207 | |||||||||
Drives_construct | WBCnstr00018109 | ||||||||
WBCnstr00018110 | |||||||||
WBCnstr00020063 | |||||||||
Construct_product | WBCnstr00018110 | ||||||||
WBCnstr00018228 | |||||||||
WBCnstr00019277 | |||||||||
WBCnstr00043014 | |||||||||
Microarray_results (39) | |||||||||
Expression_cluster (198) | |||||||||
Interaction (29) | |||||||||
Map_info | Map | I | Position | 9.53611 | Error | 0.019245 | |||
Positive | Positive_clone | F11A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4460 | |||||||
4467 | |||||||||
Pseudo_map_position | |||||||||
Reference (28) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |