WormBase Tree Display for Gene: WBGene00006843
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WBGene00006843 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Allele (132) | |||||||
Possibly_affected_by | WBVar02152819 | ||||||
WBVar02153069 | |||||||
WBVar02153167 | |||||||
WBVar02153169 | |||||||
WBVar02153170 | |||||||
WBVar02153171 | |||||||
WBVar02153173 | |||||||
WBVar02154063 | |||||||
WBVar02158600 | |||||||
WBVar02158612 | |||||||
Legacy_information | See also e2498 | ||||||
[Maduro & Pilgrim] e2498::Tc1: strong unc, almost paralyzed adults, dumpyish, tends to curl; daf-d (daf-7 suppressible), weak FITC uptake; partially Egl; similar phenotype to eDf2; eDp6. ES3 (all stages), ME0. NA4 (ed3op, ed4oc, ed9: all similar to e2498, all putative nulls). Ref. DP. | |||||||
[C.elegansII] e2498::Tc1 : severe Unc, almost paralysed adults,dumpyish, tends to curl; Daf-d, partial Egl, partial Dyf. Normal muscle ultrastructure.ES3. ME0. OA3: ed3op, ed4oc, ed9 (all similar). Cloned: encodes predicted 219 aa novel protein. unc-119:GFP expressed extensively in axons. [Maduro & Pilgrim 1995] | |||||||
Strain (2313) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (38) | |||||||
Paralog | WBGene00003966 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Structured_description | Concise_description | unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. | Paper_evidence | WBPaper00002306 | |||
WBPaper00003926 | |||||||
WBPaper00024591 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 15 Dec 2004 00:00:00 | ||||||
Automated_description | Predicted to enable lipid binding activity. Involved in several processes, including body morphogenesis; dauer larval development; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy and immunodeficiency 13. Is an ortholog of human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0111987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||
DOID:0050572 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||||
Molecular_info | Corresponding_CDS | M142.1a | |||||
M142.1b | |||||||
M142.1c | |||||||
Corresponding_transcript | M142.1a.1 | ||||||
M142.1b.1 | |||||||
M142.1c.1 | |||||||
Other_sequence (63) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern (18) | |||||||
Drives_construct | WBCnstr00000422 | ||||||
WBCnstr00000424 | |||||||
WBCnstr00000425 | |||||||
WBCnstr00000426 | |||||||
WBCnstr00001568 | |||||||
WBCnstr00001573 | |||||||
WBCnstr00001574 | |||||||
WBCnstr00001575 | |||||||
WBCnstr00001576 | |||||||
WBCnstr00001585 | |||||||
WBCnstr00001599 | |||||||
WBCnstr00001713 | |||||||
WBCnstr00001715 | |||||||
WBCnstr00001716 | |||||||
WBCnstr00001717 | |||||||
WBCnstr00001718 | |||||||
WBCnstr00001719 | |||||||
WBCnstr00001720 | |||||||
WBCnstr00001721 | |||||||
WBCnstr00001722 | |||||||
WBCnstr00001723 | |||||||
WBCnstr00001724 | |||||||
WBCnstr00001725 | |||||||
WBCnstr00001726 | |||||||
WBCnstr00001943 | |||||||
WBCnstr00001961 | |||||||
WBCnstr00001971 | |||||||
WBCnstr00004070 | |||||||
WBCnstr00004802 | |||||||
WBCnstr00005643 | |||||||
WBCnstr00005860 | |||||||
WBCnstr00006265 | |||||||
WBCnstr00006269 | |||||||
WBCnstr00006524 | |||||||
WBCnstr00006817 | |||||||
WBCnstr00006818 | |||||||
WBCnstr00006868 | |||||||
WBCnstr00006870 | |||||||
WBCnstr00006871 | |||||||
WBCnstr00006919 | |||||||
WBCnstr00006920 | |||||||
WBCnstr00006932 | |||||||
WBCnstr00006934 | |||||||
WBCnstr00006973 | |||||||
WBCnstr00007233 | |||||||
WBCnstr00007632 | |||||||
WBCnstr00007890 | |||||||
WBCnstr00007892 | |||||||
WBCnstr00008341 | |||||||
WBCnstr00008563 | |||||||
WBCnstr00008571 | |||||||
WBCnstr00008606 | |||||||
WBCnstr00009259 | |||||||
WBCnstr00009370 | |||||||
WBCnstr00009379 | |||||||
WBCnstr00009845 | |||||||
WBCnstr00010339 | |||||||
WBCnstr00012172 | |||||||
WBCnstr00012509 | |||||||
WBCnstr00014508 | |||||||
WBCnstr00014662 | |||||||
WBCnstr00014691 | |||||||
WBCnstr00014883 | |||||||
WBCnstr00015883 | |||||||
WBCnstr00016622 | |||||||
WBCnstr00017131 | |||||||
WBCnstr00018291 | |||||||
WBCnstr00018292 | |||||||
WBCnstr00018338 | |||||||
WBCnstr00018539 | |||||||
WBCnstr00018608 | |||||||
WBCnstr00018884 | |||||||
WBCnstr00019005 | |||||||
WBCnstr00019006 | |||||||
WBCnstr00019007 | |||||||
WBCnstr00019009 | |||||||
WBCnstr00019010 | |||||||
WBCnstr00019011 | |||||||
WBCnstr00019012 | |||||||
WBCnstr00019583 | |||||||
WBCnstr00020076 | |||||||
WBCnstr00020320 | |||||||
WBCnstr00020366 | |||||||
WBCnstr00020367 | |||||||
WBCnstr00020511 | |||||||
WBCnstr00020785 | |||||||
WBCnstr00020801 | |||||||
WBCnstr00020848 | |||||||
WBCnstr00021472 | |||||||
WBCnstr00021703 | |||||||
WBCnstr00021704 | |||||||
WBCnstr00021705 | |||||||
WBCnstr00021887 | |||||||
WBCnstr00022264 | |||||||
WBCnstr00022279 | |||||||
WBCnstr00022636 | |||||||
WBCnstr00022637 | |||||||
WBCnstr00022638 | |||||||
WBCnstr00022639 | |||||||
WBCnstr00022743 | |||||||
WBCnstr00022934 | |||||||
WBCnstr00023142 | |||||||
WBCnstr00038229 | |||||||
WBCnstr00038324 | |||||||
WBCnstr00039341 | |||||||
WBCnstr00040557 | |||||||
WBCnstr00040716 | |||||||
WBCnstr00041718 | |||||||
WBCnstr00042817 | |||||||
Construct_product (41) | |||||||
Antibody | WBAntibody00000421 | ||||||
WBAntibody00002511 | |||||||
WBAntibody00002695 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (150) | |||||||
Interaction (303) | |||||||
Map_info | Map | III | Position | 5.58925 | Error | 0.00446 | |
Well_ordered | |||||||
Positive | Positive_clone | C27F7 | |||||
C44B9 | |||||||
M142 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Y39A1 | |||||||
Y60D9 | |||||||
Negative | Negative_clone | K02B6 | |||||
K11D9 | |||||||
T27G1 | |||||||
Mapping_data | 2_point | 4972 | |||||
4973 | |||||||
4974 | |||||||
Multi_point | 1715 | ||||||
1716 | |||||||
1717 | |||||||
Pos_neg_data | 4970 | ||||||
4971 | |||||||
Reference (258) | |||||||
Remark | a sequence search shows strong similarity to C27H5.1 (II): a 92 a.a. region shows 26% identity, 51% similarity to UNC-119. | ||||||
Method | Gene |