WormBase Tree Display for Gene: WBGene00003100

WBGene00003100 SMap: S_parent: Sequence: Y53C12B
  Identity: Version: 1
    Name: CGC_name: mab-3 Person_evidence: WBPerson261
      Sequence_name: Y53C12B.5
      Molecular_name: Y53C12B.5a
        Y53C12B.5a.1
        CE14902
        Y53C12B.5b
        CE51560
        Y53C12B.5b.1
        Y53C12B.5b.2
      Other_name: CELE_Y53C12B.5 Accession_evidence: NDB BX284602
      Public_name: mab-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mab
    Reference_allele: WBVar00143854
    Allele (128)
    Legacy_information: e1240 : adult male tail morphology grossly abnormal often with hermaphrodite tail spike; adult male synthesizes yolk proteins; V and possibly other male lineages abnormal. ES3 (adult male) ME0. Hermaphrodite phenotype is wildtype. NA5 (e1921ts e2093 (similar but slightly weaker phenotypes than e1240)).
      See also e1240, e1921, e2093
      [C.elegansII] e1240 : adult male tail morphology grossly abnormal, often with hermaphrodite tail spike; adult male synthesizes yolk proteins; V lineages abnormal, other defects. ES3 (adult male), ME0. Hermaphrodite WT.OA4: e1921ts, e2093 (similar but slightly weaker phenotypes than e1240), e2093, e2212. [Shen and Hodgkin 1988; CB]
    Strain: WBStrain00004394
      WBStrain00004437
      WBStrain00004807
      WBStrain00006448
      WBStrain00029934
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (33)
    Paralog: WBGene00007776 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00017326 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007929 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00022060 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007058 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019521 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003114 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012832 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020708 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mab-3 encodes a DM (Doublesex and MAB-3) domain-containing protein; during development, MAB-3 plays a role in several aspects of male development; specifically, genetic studies indicate that MAB-3 likely augments the functions of the MAB-5 and EGL-5 homeodomain proteins by acting as a transcriptional repressor of ref-1, which encodes a basic helix-loop-helix (bHLH) protein that negatively regulates expression of the LIN-32 proneural bHLH protein required for male sensory ray development; in addition, MAB-3 regulates yolk protein expression in the intestine; mab-3 expression in the intestine is negatively regulated by TRA-1A, the terminal protein in the sex determination pathway; a mab-3::GFP promoter fusion is expressed in neurons and hypodermal cells as well as in the intestine; expression of the male-specific form of Drosophila Doublesex can rescue mab-3-related defects in C. elegans. Paper_evidence: WBPaper00001076
            WBPaper00003000
            WBPaper00004324
            WBPaper00025236
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Nov 2007 00:00:00
      Automated_description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ADF; SMD; and in male. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y53C12B.5a
      Y53C12B.5b
    Corresponding_CDS_history: Y53C12B.5b:wp253
    Corresponding_transcript: Y53C12B.5a.1
      Y53C12B.5b.1
      Y53C12B.5b.2
    Other_sequence: Dviv_isotig08806
      Dviv_isotig08805
      Oden_isotig19447
    Associated_feature (16)
    Gene_product_binds: WBsf977964
    Transcription_factor: WBTranscriptionFactor000032
  Experimental_info: RNAi_result: WBRNAi00020914 Inferred_automatically: RNAi_primary
      WBRNAi00057258 Inferred_automatically: RNAi_primary
      WBRNAi00027798 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr950
      Expr3376
      Expr14651
      Expr1023078
      Expr1160695
      Expr2013327
      Expr2031559
    Drives_construct: WBCnstr00000514
      WBCnstr00013819
      WBCnstr00036229
    Construct_product: WBCnstr00007577
      WBCnstr00013819
      WBCnstr00036229
    Microarray_results (28)
    Expression_cluster (121)
    Interaction: WBInteraction000000578
      WBInteraction000000880
      WBInteraction000000995
      WBInteraction000002226
      WBInteraction000002249
      WBInteraction000002250
      WBInteraction000002251
      WBInteraction000002936
      WBInteraction000002937
      WBInteraction000002938
      WBInteraction000002941
      WBInteraction000003202
      WBInteraction000003228
      WBInteraction000003244
      WBInteraction000003347
      WBInteraction000003348
      WBInteraction000003349
      WBInteraction000003352
      WBInteraction000003360
      WBInteraction000003361
      WBInteraction000003363
      WBInteraction000003388
      WBInteraction000003590
      WBInteraction000003612
      WBInteraction000003913
      WBInteraction000003921
      WBInteraction000004070
      WBInteraction000005830
      WBInteraction000005831
      WBInteraction000028392
      WBInteraction000029503
      WBInteraction000029504
      WBInteraction000031085
      WBInteraction000031149
      WBInteraction000031150
      WBInteraction000031151
      WBInteraction000031152
      WBInteraction000163501
      WBInteraction000165986
      WBInteraction000166031
      WBInteraction000166087
      WBInteraction000166089
      WBInteraction000166093
      WBInteraction000166303
      WBInteraction000166453
      WBInteraction000178863
      WBInteraction000256886
      WBInteraction000501686
      WBInteraction000501687
      WBInteraction000501688
      WBInteraction000501689
      WBInteraction000504381
      WBInteraction000504382
      WBInteraction000504383
      WBInteraction000504384
      WBInteraction000504385
      WBInteraction000521443
      WBInteraction000524189
      WBInteraction000524886
      WBInteraction000526194
      WBInteraction000526293
      WBInteraction000526522
      WBInteraction000526523
      WBInteraction000526524
      WBInteraction000526525
      WBInteraction000526526
      WBInteraction000526527
      WBInteraction000526528
      WBInteraction000526529
      WBInteraction000526530
      WBInteraction000526531
      WBInteraction000526532
      WBInteraction000526533
      WBInteraction000526534
      WBInteraction000526535
      WBInteraction000526536
      WBInteraction000526537
      WBInteraction000526538
      WBInteraction000526539
      WBInteraction000526540
      WBInteraction000526541
      WBInteraction000526542
      WBInteraction000526543
      WBInteraction000526544
      WBInteraction000526545
      WBInteraction000526546
      WBInteraction000526547
      WBInteraction000526548
      WBInteraction000526549
      WBInteraction000526550
      WBInteraction000526551
      WBInteraction000526552
      WBInteraction000526553
      WBInteraction000526554
      WBInteraction000526555
      WBInteraction000526556
      WBInteraction000526557
      WBInteraction000526558
      WBInteraction000526559
      WBInteraction000526560
      WBInteraction000526561
      WBInteraction000526562
      WBInteraction000526563
      WBInteraction000526564
      WBInteraction000526565
      WBInteraction000526566
      WBInteraction000526567
      WBInteraction000526568
      WBInteraction000526569
      WBInteraction000526570
      WBInteraction000526571
      WBInteraction000527129
      WBInteraction000527279
      WBInteraction000527436
      WBInteraction000529367
      WBInteraction000530928
      WBInteraction000533900
      WBInteraction000534032
      WBInteraction000534217
      WBInteraction000541116
      WBInteraction000541117
      WBInteraction000541118
      WBInteraction000541119
      WBInteraction000541122
      WBInteraction000541123
      WBInteraction000541124
      WBInteraction000541125
      WBInteraction000541693
      WBInteraction000541694
      WBInteraction000548753
      WBInteraction000586814
  Map_info: Map: II Position: 1.70477 Error: 0.004625
    Well_ordered
    Positive: Inside_rearr: eDf21
      Positive_clone: Y53C12B Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 337
      Multi_point: 206
        1059
        4543
      Pos_neg_data (16)
  Reference (118)
  Remark: sequence link from jah 980604
    (a) removed from sequence. only .5 in sequence list. [sdm 05/00]
  Method: Gene