e644 : slightly slow irregular sometimes rippling movement especially in reverse; slightly dumpy; variable abnormalities in VD and DD commissures; male tail abnormal bursa small fan reduced rays variably absent. ES2 ME0. NA1.
See also s472
[C.elegansII] e644 : slightly slow, irregular, sometimes rippling movement, especially in reverse; slightly dumpy; variable abnormalities in VD and DD commissures; male tail abnormal, bursa small, fan reduced, rays variably absent. 19% of embryos Nob. ES2 ME0. OA2: s472spo(pka let-328, lethal, probable null), ct344 (pka nob-5, partial maternal effect Nob, disorganized posterior). [Brenner 1974; BC; BW]
unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles.
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; muscle cell differentiation; and regulation of gene expression. Acts upstream of or within lipid homeostasis. Located in nucleus. Part of chromatin. Expressed in several structures, including body wall musculature; neurons; reproductive system; ventral nerve cord; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in several diseases, including cleft palate; cleft palate, cardiac defects, and intellectual disabillity; and open-angle glaucoma. Is an ortholog of human MEIS1 (Meis homeobox 1).