WormBase Tree Display for Gene: WBGene00002232
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WBGene00002232 | SMap | S_parent | Sequence | F11A6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | kpc | ||||||
Allele (115) | |||||||
Strain | WBStrain00035504 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (48) | |||||||
Ortholog (49) | |||||||
Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | |||
WBPaper00018607 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | ||
DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | ||||
DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | ||||
Molecular_info | Corresponding_CDS | F11A6.1a | |||||
Corresponding_CDS_history | F11A6.1b:wp245 | ||||||
Corresponding_transcript | F11A6.1b | ||||||
F11A6.1a.1 | |||||||
F11A6.1a.2 | |||||||
Other_sequence (36) | |||||||
Associated_feature (22) | |||||||
Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | |||
WBRNAi00003363 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089035 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00106792 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00044358 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027714 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct (3) | |||||||
Construct_product | WBCnstr00018110 | ||||||
WBCnstr00018228 | |||||||
WBCnstr00019277 | |||||||
WBCnstr00043014 | |||||||
Microarray_results | SMD_F11A6.1 | ||||||
172920_x_at | |||||||
173098_at | |||||||
192919_s_at | |||||||
194246_x_at | |||||||
A_12_P106446 | |||||||
A_12_P135560 | |||||||
A_12_P135561 | |||||||
A_12_P135562 | |||||||
A_12_P135563 | |||||||
A_12_P135564 | |||||||
Aff_F11A6.1A | |||||||
Aff_F11A6.1B | |||||||
GPL13394_WBGene00002232 | |||||||
GPL13914_F11A6.1 | |||||||
GPL14144_F11A6.1b_1781-1840_0.892_10_C | |||||||
GPL14144_F11A6.1b_1857-1916_0.936_2_A | |||||||
GPL14144_F11A6.1b_1983-2042_0.926_4_B | |||||||
GPL19516_CGZ0015512 | |||||||
GPL19516_CGZ0015513 | |||||||
GPL19516_CGZ0015514 | |||||||
GPL21109_F11A6.1a.1 | |||||||
GPL21109_F11A6.1a.2 | |||||||
GPL21109_F11A6.1b | |||||||
GPL3518_CE17653 | |||||||
GPL3518_CE17654 | |||||||
GPL8304_CE_WBGene00002232_A | |||||||
GPL8304_CE_WBGene00002232_B | |||||||
GPL8304_CE_WBGene00002232_C | |||||||
GPL8673_F11A6_1aP00700 | |||||||
GPL8673_F11A6_1aP00940 | |||||||
GPL8673_F11A6_1aP01184 | |||||||
GPL8673_F11A6_1bP00940 | |||||||
GPL8673_F11A6_1bP01183 | |||||||
GPL8673_F11A6_1bP02145 | |||||||
GPL9450_F11A6.1a | |||||||
GPL9450_F11A6.1b | |||||||
cea2.d.02171 | |||||||
cea2.d.19891 | |||||||
Expression_cluster (198) | |||||||
Interaction (29) | |||||||
Map_info | Map | I | Position | 9.53611 | Error | 0.019245 | |
Positive | Positive_clone | F11A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4460 | |||||
4467 | |||||||
Pseudo_map_position | |||||||
Reference (28) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |