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WormBase Tree Display for Gene: WBGene00001827

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Name Class

WBGene00001827SMapS_parentSequenceC46A5
IdentityVersion1
NameCGC_namehcf-1
Sequence_nameC46A5.9
Molecular_nameC46A5.9
C46A5.9.1
CE26914
Other_nameCELE_C46A5.9Accession_evidenceNDBBX284604
Public_namehcf-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhcf
Allele (41)
StrainWBStrain00031490
WBStrain00040638
RNASeq_FPKM (74)
GO_annotation (33)
Contained_in_operonCEOP4614
OrthologWBGene00059331Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00037233Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00139420Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00106693Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00123260Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00193720Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00223049Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g10743Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g7946Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g21283Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g5588Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g7277Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g2886Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g14712Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g9117Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g6928Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g6612Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00754.g13899Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-hcf-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold23.g105Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold23.g106Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00368.g10252Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_19174Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_014849Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04540Oscheius tipulaeFrom_analysisWormBase-Compara
Sp34_40099400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIV_pilon.g10914Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240938Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00277131Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00283337Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00289181Trichuris murisFrom_analysisWormBase-Compara
WBGene00289183Trichuris murisFrom_analysisWormBase-Compara
SGD:S000003470Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
OrthoInspector
SGD:S000001201Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
OrthoInspector
FB:FBgn0039904Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050417-203Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
ZFIN:ZDB-GENE-030912-10Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030131-2411Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoFinder
Panther
PhylomeDB
SonicParanoid
HGNC:4839Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:24972Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
MGI:105942Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1915183Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
RGD:1307385Rattus norvegicusFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
RGD:1563804Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00009978Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013461Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021751Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionhcf-1 encodes the C. elegans ortholog of human host cell factor (HCF-1), a transcriptional regulator that associates with histone modification enzymes and plays a role in cell cycle progression; in C. elegans, hcf-1 plays a role in regulation of cell division and mitotic histone modification; in addition, HCF-1 functions in determination of adult lifespan as a negative regulator of DAF-16, with which it physically interacts; HCF-1 is a ubiquitously expressed protein that localizes to the nucleus.Paper_evidenceWBPaper00031249
WBPaper00032232
Curator_confirmedWBPerson1843
Date_last_updated22 Dec 2009 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111814Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4839)
Molecular_info (4)
Experimental_infoRNAi_resultWBRNAi00088935Inferred_automaticallyRNAi_primary
WBRNAi00042584Inferred_automaticallyRNAi_primary
WBRNAi00081844Inferred_automaticallyRNAi_primary
WBRNAi00108478Inferred_automaticallyRNAi_primary
WBRNAi00081815Inferred_automaticallyRNAi_primary
WBRNAi00062165Inferred_automaticallyRNAi_primary
WBRNAi00081891Inferred_automaticallyRNAi_primary
WBRNAi00012019Inferred_automaticallyRNAi_primary
WBRNAi00081780Inferred_automaticallyRNAi_primary
WBRNAi00108483Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00005314
WBCnstr00009024
WBCnstr00009025
WBCnstr00036664
Construct_productWBCnstr00005314
WBCnstr00009025
WBCnstr00010947
WBCnstr00036664
Regulate_expr_cluster (17)
AntibodyWBAntibody00000977
WBAntibody00001472
Microarray_results (22)
Expression_cluster (152)
Interaction (118)
WBProcessWBbiopr:00000001
Map_infoMapIVPosition3.47224Error0.000901
PositivePositive_cloneC46A5Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4397
4935
Pseudo_map_position
Reference (32)
RemarkSequence connection from [Liu Y, Hengartner MO, Herr W]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene