pak-2 encodes, by alternative splicing, at least two isoforms of aputative p21-activated kinase, orthologous to Drosophila melanogasterMUSHROOM BODIES TINY; pak-2 is expressed in pharynx, thepharyngeal-intestinal valve, vulva, and spermatheca; pak-2(ok332), aprobable null allele, has no obvious mutant phenotype in isolation andhas no effect on the axonal guidance phenotype of max-2(cy2), but showssome embryonic defects and L1 lethality as a double mutant with the nullpak-1(ok448).
Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Is an ortholog of human PAK4 (p21 (RAC1) activated kinase 4).
Gene name created from parsing 'genotype' field from CGC strain information
CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.