WormBase Tree Display for Gene: WBGene00006742

WBGene00006742 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-2 Person_evidence: WBPerson261
      Sequence_name: T02C5.5
      Molecular_name (45)
      Other_name: CELE_T02C5.5 Accession_evidence: NDB BX284606
      Public_name: unc-2
    DB_info: Database: AceView gene XD330
        WormQTL gene WBGene00006742
        WormFlux gene WBGene00006742
        OMIM disease 141500
          gene 601011
            601013
        NDB locus_tag CELE_T02C5.5
        Panther gene CAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663
          family PTHR45628
        NCBI gene 180570
        RefSeq protein NM_001348590.4
            NM_001348592.5
            NM_001348589.4
            NM_001348588.4
            NM_001368494.4
            NM_001348593.4
            NM_001348594.5
            NM_001348597.2
            NM_001348591.4
            NM_001368497.5
            NM_001348595.4
            NM_001368495.4
            NM_001348596.5
            NM_171638.3
            NM_001368496.4
        TrEMBL UniProtAcc (15)
        UniProt_GCRP UniProtAcc A0A3B1E663
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:6364 Homo sapiens Paper_evidence: WBPaper00006272
          Accession_evidence: OMIM 141500
          Curator_confirmed: WBPerson324
          Date_last_updated: 14 Apr 2014 00:00:00
    Potential_model: DOID:10024 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0080454 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0050956 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0112205 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1392)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:0111181 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0050214 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:0050990 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:6364 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
    Disease_relevance: Mutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans. Homo sapiens Paper_evidence: WBPaper00006272
          Accession_evidence: OMIM 601011
          Curator_confirmed: WBPerson324
          Date_last_updated: 14 Apr 2014 00:00:00
  Models_disease_in_annotation: WBDOannot00000025
  Molecular_info (5)
  Experimental_info: RNAi_result (18)
    Expr_pattern (13)
    Drives_construct: WBCnstr00003100
      WBCnstr00003101
      WBCnstr00004845
      WBCnstr00004847
      WBCnstr00038221
    Construct_product: WBCnstr00005852
      WBCnstr00005853
      WBCnstr00005854
      WBCnstr00020432
      WBCnstr00022471
      WBCnstr00023025
      WBCnstr00023027
    Microarray_results (47)
    Expression_cluster (201)
    Interaction (139)
    Anatomy_function: WBbtf0544
      WBbtf0547
      WBbtf0550
  Map_info: Map: X Position: -13.7946 Error: 0.063386
    Well_ordered
    Positive: Positive_clone: T02C5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 145
        153
        154
        155
        156
        157
        3151
        4456
        4457
        7099
      Multi_point (28)
      Pos_neg_data (23)
    Landmark_gene
  Reference: WBPaper00000031
    WBPaper00000164
    WBPaper00000608
    WBPaper00001477
    WBPaper00001709
    WBPaper00001722
    WBPaper00001852
    WBPaper00002074
    WBPaper00002168
    WBPaper00002297
    WBPaper00002487
    WBPaper00002590
    WBPaper00002756
    WBPaper00002824
    WBPaper00002832
    WBPaper00003024
    WBPaper00003038
    WBPaper00003300
    WBPaper00003760
    WBPaper00003764
    WBPaper00003955
    WBPaper00004361
    WBPaper00005102
    WBPaper00005686
    WBPaper00005734
    WBPaper00005753
    WBPaper00005799
    WBPaper00006005
    WBPaper00006049
    WBPaper00006052
    WBPaper00006076
    WBPaper00006103
    WBPaper00006167
    WBPaper00006272
    WBPaper00006296
    WBPaper00006384
    WBPaper00006402
    WBPaper00006434
    WBPaper00010480
    WBPaper00010908
    WBPaper00010992
    WBPaper00011094
    WBPaper00011099
    WBPaper00014210
    WBPaper00014234
    WBPaper00014761
    WBPaper00014772
    WBPaper00014841
    WBPaper00014842
    WBPaper00014959
    WBPaper00014960
    WBPaper00015004
    WBPaper00015440
    WBPaper00015459
    WBPaper00015628
    WBPaper00016359
    WBPaper00016388
    WBPaper00016418
    WBPaper00016621
    WBPaper00016714
    WBPaper00016926
    WBPaper00017046
    WBPaper00017112
    WBPaper00017152
    WBPaper00017175
    WBPaper00017182
    WBPaper00017184
    WBPaper00017304
    WBPaper00017365
    WBPaper00017383
    WBPaper00017406
    WBPaper00017412
    WBPaper00017428
    WBPaper00018051
    WBPaper00018323
    WBPaper00018338
    WBPaper00018918
    WBPaper00019016
    WBPaper00019070
    WBPaper00019209
    WBPaper00019229
    WBPaper00019278
    WBPaper00021934
    WBPaper00022084
    WBPaper00022149
    WBPaper00022177
    WBPaper00022459
    WBPaper00022530
    WBPaper00022744
    WBPaper00022821
    WBPaper00022843
    WBPaper00022945
    WBPaper00022963
    WBPaper00023702
    WBPaper00023731
    WBPaper00023984
    WBPaper00024131
    WBPaper00024295
    WBPaper00024600
    WBPaper00024867
    WBPaper00024990
    WBPaper00025467
    WBPaper00026068
    WBPaper00026126
    WBPaper00026194
    WBPaper00026618
    WBPaper00026667
    WBPaper00026734
    WBPaper00026866
    WBPaper00026981
    WBPaper00026988
    WBPaper00027180
    WBPaper00027274
    WBPaper00027304
    WBPaper00027305
    WBPaper00027615
    WBPaper00027624
    WBPaper00027747
    WBPaper00028105
    WBPaper00028187
    WBPaper00028258
    WBPaper00028340
    WBPaper00028384
    WBPaper00028433
    WBPaper00028808
    WBPaper00028850
    WBPaper00029015
    WBPaper00029021
    WBPaper00029025
    WBPaper00029334
    WBPaper00029404
    WBPaper00029410
    WBPaper00030291
    WBPaper00030337
    WBPaper00031000
    WBPaper00031175
    WBPaper00031254
    WBPaper00031915
    WBPaper00031982
    WBPaper00032122
    WBPaper00032389
    WBPaper00032687
    WBPaper00032811
    WBPaper00032896
    WBPaper00033037
    WBPaper00034089
    WBPaper00035163
    WBPaper00035989
    WBPaper00037330
    WBPaper00037332
    WBPaper00037339
    WBPaper00038491
    WBPaper00038566
    WBPaper00039244
    WBPaper00039245
    WBPaper00039865
    WBPaper00039901
    WBPaper00040141
    WBPaper00040144
    WBPaper00040284
    WBPaper00042167
    WBPaper00042396
    WBPaper00042931
    WBPaper00043400
    WBPaper00043415
    WBPaper00043908
    WBPaper00044263
    WBPaper00045955
    WBPaper00045968
    WBPaper00046703
    WBPaper00047904
    WBPaper00048069
    WBPaper00048388
    WBPaper00049114
    WBPaper00049806
    WBPaper00051165
    WBPaper00052786
    WBPaper00053608
    WBPaper00055090
    WBPaper00057024
    WBPaper00057095
    WBPaper00060930
    WBPaper00061313
    WBPaper00061401
    WBPaper00061408
    WBPaper00061654
    WBPaper00063130
    WBPaper00063570
    WBPaper00063852
    WBPaper00063884
    WBPaper00063950
    WBPaper00064058
    WBPaper00064165
    WBPaper00064195
    WBPaper00064506
    WBPaper00065040
    WBPaper00065118
    WBPaper00065262
    WBPaper00065342
    WBPaper00065360
    WBPaper00066029
  Method: Gene