[C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1/ME2. NA1. [CB]
unc-122 encodes a type II transmembrane protein with extracellular collagen-like repeats and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 negatively regulates cholinergic neuromuscular synaptic transmission, and is required for normal locomotion and morphology of the DVB motorneuron; mosaic analysis indicates that UNC-122 acts in muscle cells to regulate synaptic transmission and locomotory behavior; UNC-122 expression is observed in body wall muscle cells and the coelomocytes; in body wall muscles, UNC-122 localizes to the postsynaptic neuromuscular junction.
Involved in negative regulation of cholinergic synaptic transmission. Located in postsynaptic membrane. Expressed in body wall musculature and coelomocyte. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is an ortholog of human GLDN (gliomedin) and OLFML2B (olfactomedin like 2B).