gsp-4 encodes an ortholog of protein phosphatase 1 gamma, a Glc7/PP1 phosphatase (HGNC:PPP1CA); GSP-4 is nearly identical to GSP-3, and the two proteins appear to function redundantly during sperm development; GSP-3/4 activity is required for chromosome partitioning during sperm meiosis and for sperm motility, specifically for pseudopod development and a normal rate of pseudopodial treadmilling; in regulating sperm development, GSP-3/4 functions upstream of, and regulates the localization of, the major sperm proteins (MSPs); GSP-3/4 may also play a role in egg laying; GSP-3/4 is expresed at high levels in sperm, with strong localization seen around meiotic and mature sperm DNA.
Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of pseudopodium assembly and reproductive process. Located in cytoplasm and pseudopodium. Part of chromatin. Expressed in ILsoDL; ILsoVL; anal sphincter muscle; intestine; and sperm.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.