WormBase Tree Display for Variation: WBVar00142932

WBVar00142932 Name: Public_name: e47
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (24)
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006751
    Interactor: WBInteraction000500226
      WBInteraction000501652
      WBInteraction000555717
      WBInteraction000555718
      WBInteraction000555719
      WBInteraction000555720
      WBInteraction000555721
      WBInteraction000555724
      WBInteraction000555725
  Genetics: Mapping_data (3)
  Description: Phenotype: WBPhenotype:0000017 Paper_evidence: WBPaper00032011
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Animals were resistant to 1mM aldicarb, as assayed by the % of animals paralyzed over time. Paper_evidence: WBPaper00032011
            Curator_confirmed: WBPerson712
          Ric Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00032011
              Curator_confirmed: WBPerson712
      WBPhenotype:0000019 Paper_evidence: WBPaper00001709
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: slow pharyngeal pumping Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003681 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000020 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003681 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000153 Paper_evidence: WBPaper00032190
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased contractions. Paper_evidence: WBPaper00032190
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: zxIs6 Paper_evidence: WBPaper00032190
              Curator_confirmed: WBPerson712
      WBPhenotype:0000164 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slightly thin Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000229 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slightly small Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000315 Paper_evidence: WBPaper00046308
        Curator_confirmed: WBPerson10425
      WBPhenotype:0000352 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        Remark: Jerky backward motion Paper_evidence: WBPaper00001709
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000420 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: hypersensitive to levamisole Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00028886
        Curator_confirmed: WBPerson48
        Remark: Localization of the synaptic protein SNB-1 is abnormal, based on expression analysis of SNB-1::VENUS; expression appears diffuse across the plasma membrane. Paper_evidence: WBPaper00028886
            Curator_confirmed: WBPerson48
      WBPhenotype:0000507 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: elevated acetylcholine levels Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000544 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: kinker, jerky ratchet-like movement especially in reverse Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000594 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Some migration defects. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000616 Paper_evidence: WBPaper00025079
        Curator_confirmed: WBPerson712
        Remark: GLR-1::GFP puncta intensity and width were significantly different from those in wild-type animals. Paper_evidence: WBPaper00025079
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00000031
        Curator_confirmed: WBPerson48
      WBPhenotype:0000679 Paper_evidence: WBPaper00005349
        Curator_confirmed: WBPerson10038
        Remark: quoted from paper: "in a screen for mutants that have increased abundance of GLR-1::GFP in the ventral nerve cord (data not shown). Similar defects in GLR-1::GFP abundance were observed in other unc-11 mutants, including strains carrying the putative null allele, e47 (Figure 2)." Figure 2 title: " Mutants Lacking unc-11 AP180 Had Increased Abundance of GLR-1::GFP in the Ventral Nerve Cord" Paper_evidence: WBPaper00005349
            Curator_confirmed: WBPerson10038
        EQ_annotations: Anatomy_term: WBbt:0005829 PATO:0000460 Paper_evidence: WBPaper00005349
                Curator_confirmed: WBPerson10038
        Phenotype_assay: Genotype: nuIs24 [GLR-1::GFP] Paper_evidence: WBPaper00005349
              Curator_confirmed: WBPerson10038
    Phenotype_not_observed (3)
  Reference (15)
  Remark
  Method: Allele