Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00091661

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00091661EvidencePerson_evidenceWBPerson14358
NamePublic_nameok364
Other_nameC01B7.6.1:c.3291_5461del
CE06730:p.Ile1098AsnfsTer2
HGVSgCHROMOSOME_V:g.8813601_8815821del
Sequence_detailsSMapS_parentSequenceC01B7
Flanking_sequencesagttgggctgtatggaggacgaggagaatacaattgaacgttgttatgggagcgaatggc
Mapping_targetC01B7
Type_of_mutationDeletion
PCR_productOK364_external
OK364_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00031377
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00004457
TranscriptC01B7.6.1 (11)
InteractorWBInteraction000500068
WBInteraction000500069
WBInteraction000534756
WBInteraction000537519
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Remark% animals paralyzed after 60 min on 1mM aldicarb was significantly higher than % N2 animals paralyzed.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007833PATO:0001549Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000397Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 loss-of-function mutants have large defects in evoked responses to harsh touch. In wild-type animals, harsh touch resulted in robust reverse movement. In contrast, while all rpm-1 mutants responded to the harsh touch stimulus (n = 300), we observed a 40% reduction in reverse locomotion after harsh touch.Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Rescued_by_transgeneWBTransgene00021462
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
WBPhenotype:0000420Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Remark% animals paralyzed after 60 min on 200mM levamisole was significantly higher than % N2 animals paralyzed under same conditions.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000646Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
RemarkAnalysis of the speed of locomotion showed that rpm-1 mutants moved 15-20% more slowly than wild-type animals during both forward and backward movement.Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Rescued_by_transgeneWBTransgene00021462
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
WBPhenotype:0001933Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkAnimals exhibit a temperature-sensitive Sam (synaptic vesicle tag abnormal in mechanosensory neuron) phenotype similar to mec-15 mutants.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
WBPhenotype:0001983Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 loss-of-function mutants have relatively mild abnormalities in exploratory locomotion. After removal from food, wild-type animals spent most of their time moving forward with small amounts of backward movement during reversals. rpm-1 mutants spent significantly less time moving forward compared with wild-type animals. The reduction in time spent moving forward was reflected by increased time spent moving backward, as opposed to staying stationary or performing compound/complex reorientationsPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Rescued_by_transgeneWBTransgene00021462
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
WBPhenotype:0002469Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 loss-of-function mutants have large defects in learning associated with tap habituation. RPM-1 function in the mechanosensory neurons affects habituation. Transgenic expression of RPM-1 in adult animals failed to rescue habituation defects, consistent with developmental defects in rpm-1 mutants resulting in impaired habituation. Genetic analysis showed that other regulators of neuronal development that function in the rpm-1 pathway (including glo-4, fsn-1, and dlk-1) also affected habituation. rpm-1 (lf) mutants had a significantly higher habituation level than wild-type animals; rpm-1 mutants fail to decrease their response to tap over time. rpm-1 mutants had a significant defect in habituation at all ages tested. Our results suggest that adult-specific expression of RPM-1 is not sufficient to rescue the habituation defects in rpm-1 mutants.Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Rescued_by_transgeneWBTransgene00021463
WBTransgene00021462
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000315Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkAnimals are touch sensitive.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
WBPhenotype:0000518Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 mutants developed and aged at a similar rate to wild-type animals as assessed by the onset of the L4 larval stage and egg-laying in synchronized populations (data not shown).Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
WBPhenotype:0000905Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkAnimals exhibited normal cell-body morphology.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
WBPhenotype:0001739Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 mutants developed and aged at a similar rate to wild-type animals as assessed by the onset of the L4 larval stage and egg-laying in synchronized populations (data not shown).Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
WBPhenotype:0002423Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Remark"Multiple MAP kinase pathways were not required for Neuro-Nmnat1(gcIs30[Neuro-m-nonN-Nmnat1]) hypoxic survival." (Figure S3c)Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
EQ_annotationsGO_termGO:0001666PATO:0000460Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Phenotype_assayGenotypegcIs30 [Neuro-m-nonN-Nmnat1]Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
WBPhenotype:0004027Paper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Remarkrpm-1 (lf) mutants did not have a defect in the initial response totap stimulus. In fact, we found a very mild, but statistically significant,increase in the reversal probability in response to tapPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00048707
Curator_confirmedWBPerson712
ReferenceWBPaper00031872
WBPaper00035070
WBPaper00023967
WBPaper00026122
WBPaper00048707
WBPaper00049307
RemarkLast updated on 29 Nov 2002
Allele sequenced by Stacey EdwardsCurator_confirmedWBPerson2970
Sequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele