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WormBase Tree Display for Variation: WBVar00142903

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Name Class

WBVar00142903EvidencePaper_evidenceWBPaper00033138
NamePublic_namee5
Other_nameCE51917:p.Gln216Ter
R07D5.1g.1:c.469C>T
CE51912:p.Gln240Ter
R07D5.1a.2:c.646C>T
CE06279:p.Gln216Ter
CE51958:p.Gln157Ter
R07D5.1c.1:c.286C>T
CE51924:p.Gln157Ter
R07D5.1e.1:c.718C>T
R07D5.1b.1:c.442C>T
R07D5.1j.1:c.646C>T
R07D5.1i.1:c.508C>T
R07D5.1d.1:c.718C>T
CE51935:p.Gln170Ter
R07D5.1a.1:c.646C>T
CE51942:p.Gln170Ter
CE44016:p.Gln148Ter
CE51947:p.Gln240Ter
CE44028:p.Gln96Ter
R07D5.1h.1:c.508C>T
R07D5.1f.1:c.469C>T
HGVSgCHROMOSOME_X:g.15124688G>A
Sequence_detailsSMapS_parentSequenceR07D5
Flanking_sequencestccacgtgaaatttattcgcgtagaaatcgaaaattggctattaccaatgggtgccgtttat
Mapping_targetR07D5
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00033138
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004076
WBStrain00040856
WBStrain00054742
WBStrain00056070
LaboratoryCB
OJ
StatusLive
AffectsGeneWBGene00006747
TranscriptR07D5.1i.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1i.1:c.508C>T
HGVSpCE51935:p.Gln170Ter
cDNA_position899
CDS_position508
Protein_position170
Exon_number6/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1a.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1a.2:c.646C>T
HGVSpCE06279:p.Gln216Ter
cDNA_position822
CDS_position646
Protein_position216
Exon_number6/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1f.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1f.1:c.469C>T
HGVSpCE51924:p.Gln157Ter
cDNA_position469
CDS_position469
Protein_position157
Exon_number5/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1h.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1h.1:c.508C>T
HGVSpCE51942:p.Gln170Ter
cDNA_position508
CDS_position508
Protein_position170
Exon_number5/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1c.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1c.1:c.286C>T
HGVSpCE44028:p.Gln96Ter
cDNA_position767
CDS_position286
Protein_position96
Exon_number6/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1b.1:c.442C>T
HGVSpCE44016:p.Gln148Ter
cDNA_position442
CDS_position442
Protein_position148
Exon_number4/9
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1a.1:c.646C>T
HGVSpCE06279:p.Gln216Ter
cDNA_position723
CDS_position646
Protein_position216
Exon_number7/13
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1g.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1g.1:c.469C>T
HGVSpCE51958:p.Gln157Ter
cDNA_position547
CDS_position469
Protein_position157
Exon_number6/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1d.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1d.1:c.718C>T
HGVSpCE51912:p.Gln240Ter
cDNA_position718
CDS_position718
Protein_position240
Exon_number5/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1e.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1e.1:c.718C>T
HGVSpCE51947:p.Gln240Ter
cDNA_position718
CDS_position718
Protein_position240
Exon_number5/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
R07D5.1j.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScR07D5.1j.1:c.646C>T
HGVSpCE51917:p.Gln216Ter
cDNA_position646
CDS_position646
Protein_position216
Exon_number5/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
InteractorWBInteraction000518923
WBInteraction000518930
IsolationMutagenEMS
GeneticsInterpolated_map_positionX22.0113
Mapping_dataIn_2_point494
3170
3636
6060
6165
In_multi_point419
582
583
2417
2783
5472
DescriptionPhenotypeWBPhenotype:0000002Paper_evidenceWBPaper00033075
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
Remarkunc-7 mutant animals move in a rigid and twisted manner referred as "kinkers"Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
kinker in forward movement, e5/Df similar, null phenotype.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00033075
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
WBPhenotype:0000017Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Remarkunc-7 mutants were aldicarb resistantPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0000164Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkslightly thin, e5/Df similar, null phenotype.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectNullPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000247Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
RemarkMutants behave like WT in a Na+ gradient assay; however, mutants are 40% responsive to Na+ in a behavior orientation assay. WT worms are 95% responsive (based on sustained distance from attractant).Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0000254Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
RemarkMutants are 50% responsive to Cl- in behavior orientation assay (based on sustained distance from attractant), WT are 70% responsive.Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0000324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000353Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
RemarkMutants mostly move backwards, even in the presence of an attractant. Forward motion is possible, all mutants can be prodded to go forward.Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0000425Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
RemarkUNC-7 antibody staining is absent in mutantsPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0000643Paper_evidenceWBPaper00000031
WBPaper00033138
Curator_confirmedWBPerson48
WBPerson621
WBPhenotype:0000847Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Remarkunc-7 is required for the even distribution of GFP::SYD-2 and UNC-10 active zone markersPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0001005Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001639Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001716Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001727Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002292Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002294Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002298Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002308Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002323Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002335Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002347Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002348Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002548Paper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
Remarkuncoordinated forward and reversal body bend propagationPaper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
WBPhenotype:0002549Paper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
Remarkfrequent spontaneous short reversals that interrupt forward movement. Overtime the animal exhibits slow reversalsPaper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
WBPhenotype:0002550Paper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
Remarkover half of the time, animals exhibit a 'pause'-like state - a pulled mid-body posture when head and tail actively pull the anterior and posterior bodies into opposite directions. Overtime the animal exhibits slow reversalsPaper_evidenceWBPaper00040432
Curator_confirmedWBPerson720
WBPhenotype:0004017Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkmoves backward better than forward, e5/Df similar, null phenotype.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectNullPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000637Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0000641Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkactive, healthy, e5/Df similar, null phenotype.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectNullPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000672Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
RemarkThe synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animalsPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0001323Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
RemarkThe synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animalsPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0001669Paper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
RemarkThe synaptic vesicle markers (SNB-1::GFP and SNG-1::GFP) showed normal morphology, as well as normal number and distribution of dorsal or lateral cord puncta in unc-7 animalsPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00033075
Curator_confirmedWBPerson2021
WBPhenotype:0002014Paper_evidenceWBPaper00027055
Curator_confirmedWBPerson557
Remarkunc-7(e5) did not inhibit the electrical coupling of body wall muscle cells.Paper_evidenceWBPaper00027055
Curator_confirmedWBPerson557
ReferenceWBPaper00040432
WBPaper00043908
WBPaper00000031
WBPaper00000214
WBPaper00012735
WBPaper00033075
WBPaper00027055
WBPaper00033138
WBPaper00065317
WBPaper00065804
WBPaper00065757
MethodSubstitution_allele