WormBase Tree Display for Variation: WBVar00146335

WBVar00146335 Name: Public_name: gm103
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00028737
    Laboratory: NG
    Status: Live
  Affects: Gene: WBGene00003239
    Interactor (13)
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
        Penetrance: Incomplete: 55 percent Paper_evidence: WBPaper00002978
              Curator_confirmed: WBPerson557
      WBPhenotype:0000010 Paper_evidence: WBPaper00035198
        Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00035198
              Curator_confirmed: WBPerson712
      WBPhenotype:0000230 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
        Penetrance: Low: 21 percent Paper_evidence: WBPaper00002978
              Curator_confirmed: WBPerson557
      WBPhenotype:0000273 Paper_evidence: WBPaper00035198
          WBPaper00035920
        Curator_confirmed: WBPerson712
          WBPerson11395
        Remark: Animals exhibit reduced thrashing compared to wild type animals. Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
          Figure 1, body bends per minute are reduced in mig-2 alleles, suppressed by HDAC-6 overexpression Paper_evidence: WBPaper00035920
            Curator_confirmed: WBPerson11395
        Rescued_by_transgene: WBTransgene00006116
        Variation_effect: Gain_of_function_undetermined_type: Paper_evidence: WBPaper00035920
            Curator_confirmed: WBPerson11395
          Hypermorph_gain_of_function: Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
      WBPhenotype:0000406 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
        Penetrance: Low: 1 percent Paper_evidence: WBPaper00002978
              Curator_confirmed: WBPerson557
      WBPhenotype:0000571 Paper_evidence: WBPaper00035198
        Curator_confirmed: WBPerson712
        Remark: Synaptic vesicles are misaccumulated in GABAergic D-type motor neurons as assayed by gaps in the pattern of fluorescence of juIs1[Punc-25::SNB-1::GFP] labeled vesicles. Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005190 PATO:0000460 Paper_evidence: WBPaper00035198
                Curator_confirmed: WBPerson712
            WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00035198
                Curator_confirmed: WBPerson712
            WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00035198
                Curator_confirmed: WBPerson712
      WBPhenotype:0000631 Paper_evidence: WBPaper00035198
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit anterior convulsions when treated with pentylenetetrazole(PTZ). Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00035198
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004251 Paper_evidence: WBPaper00035198
              Curator_confirmed: WBPerson712
      WBPhenotype:0000633 Paper_evidence: WBPaper00045955
        Curator_confirmed: WBPerson557
        Remark: Branch defects scored in PLM neuron. Paper_evidence: WBPaper00045955
            Curator_confirmed: WBPerson557
        Penetrance: Incomplete: Paper_evidence: WBPaper00045955
              Curator_confirmed: WBPerson557
      WBPhenotype:0000643 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
        Penetrance: Complete: 100 percent Paper_evidence: WBPaper00002978
              Curator_confirmed: WBPerson557
      WBPhenotype:0000700 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
        Penetrance: Low: 12 percent Paper_evidence: WBPaper00002978
              Curator_confirmed: WBPerson557
    Phenotype_not_observed: WBPhenotype:0000163 Paper_evidence: WBPaper00002978
        Curator_confirmed: WBPerson557
      WBPhenotype:0000885 Paper_evidence: WBPaper00038317
        Curator_confirmed: WBPerson712
        Remark: Cell corpses do not accumulate. Paper_evidence: WBPaper00038317
            Curator_confirmed: WBPerson712
      WBPhenotype:0001652 Paper_evidence: WBPaper00032446
        Curator_confirmed: WBPerson2021
  Disease_info: Models_disease: DOID:1826
    Models_disease_in_annotation: WBDOannot00000557
  Reference: WBPaper00038317
    WBPaper00032446
    WBPaper00002978
    WBPaper00035198
    WBPaper00011146
    WBPaper00030278
    WBPaper00035920
    WBPaper00045955
  Method: Allele