WormBase Tree Display for Variation: WBVar00250781

WBVar00250781 Name: Public_name: tm1817
    Other_name: D2030.9b.1:c.677+25_889-128del
      D2030.9a.2:c.800+25_1012-128del
      D2030.9c.1:c.800+25_1012-128del
      D2030.9e.1:c.581+25_793-128del
      D2030.9d.1:c.581+25_793-128del
      D2030.9a.1:c.800+25_1012-128del
    HGVSg: CHROMOSOME_I:g.7599392_7600026del
  Sequence_details: SMap: S_parent: Sequence: D2030
    Flanking_sequences: aagagagtgagtacatttcacagcaaaaaa atttattcaaagtttctcaacatgacattg
    Mapping_target: D2030
    Source_location: 7 CHROMOSOME_I 7599391 7600027 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm1817_external
      tm1817_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00055405
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1817
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00008419
    Transcript: D2030.9c.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9c.1:c.800+25_1012-128del
        Intron_number: 6-7/11
        Exon_number: 7/12
      D2030.9d.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9d.1:c.581+25_793-128del
        Intron_number: 3-4/7
        Exon_number: 4/8
      D2030.9a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9a.1:c.800+25_1012-128del
        Intron_number: 6-7/11
        Exon_number: 7/12
      D2030.9e.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9e.1:c.581+25_793-128del
        Intron_number: 3-4/7
        Exon_number: 4/8
      D2030.9b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9b.1:c.677+25_889-128del
        Intron_number: 5-6/10
        Exon_number: 6/11
      D2030.9a.2 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2030.9a.2:c.800+25_1012-128del
        Intron_number: 6-7/11
        Exon_number: 7/12
    Interactor: WBInteraction000051412
      WBInteraction000503935
      WBInteraction000520023
      WBInteraction000520024
      WBInteraction000520025
      WBInteraction000520026
      WBInteraction000520027
      WBInteraction000520028
      WBInteraction000521021
      WBInteraction000521022
      WBInteraction000524193
      WBInteraction000525382
  Isolation: Mutagen: TMP/UV
  Genetics: Map: I
  Description: Phenotype: WBPhenotype:0000017 Paper_evidence: WBPaper00042215
        Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
          WBPerson590
          WBPerson557
        Remark: Comments to the National Bioresource Project of Japan: Dr. J. Kaplan: resistant to aldicarb Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
          wdr-23 mutants were highly resistant to the paralytic effects of aldicarb. Paper_evidence: WBPaper00042215
            Curator_confirmed: WBPerson557
        Affected_by: Molecule: WBMol:00003650 Person_evidence: WBPerson7743
              Curator_confirmed: WBPerson712
      WBPhenotype:0000031 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. K. Strange: Gro Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000050 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. K. Strange: Emb Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000061 Paper_evidence: WBPaper00046904
        Curator_confirmed: WBPerson6532
      WBPhenotype:0000142 Paper_evidence: WBPaper00032980
        Curator_confirmed: WBPerson6532
        Penetrance: Complete: Paper_evidence: WBPaper00032980
              Curator_confirmed: WBPerson6532
        Recessive: Paper_evidence: WBPaper00032980
          Curator_confirmed: WBPerson6532
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032980
            Curator_confirmed: WBPerson6532
      WBPhenotype:0000154 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. K. Strange: small brood size Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000420 Paper_evidence: WBPaper00042215
        Curator_confirmed: WBPerson557
        Remark: wdr-23 mutants were hypersensitive to the paralytic effects of the muscle agonist levamisole. Paper_evidence: WBPaper00042215
            Curator_confirmed: WBPerson557
      WBPhenotype:0000643 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. J. Kaplan: Unc. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0001206 Paper_evidence: WBPaper00042215
        Curator_confirmed: WBPerson557
        Remark: wdr-23 mutants had reduced locomotion rates and spent significantly less time moving compared to wild type animals. Paper_evidence: WBPaper00042215
            Curator_confirmed: WBPerson557
      WBPhenotype:0001213 Paper_evidence: WBPaper00042215
        Curator_confirmed: WBPerson557
        Remark: wdr-23 mutants had reduced locomotion rates and spent significantly less time moving compared to wild type animals. Paper_evidence: WBPaper00042215
            Curator_confirmed: WBPerson557
      WBPhenotype:0001236 Paper_evidence: WBPaper00032980
        Curator_confirmed: WBPerson6532
        Penetrance: Complete: Paper_evidence: WBPaper00032980
              Curator_confirmed: WBPerson6532
        Recessive: Paper_evidence: WBPaper00032980
          Curator_confirmed: WBPerson6532
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032980
            Curator_confirmed: WBPerson6532
      WBPhenotype:0001620 Paper_evidence: WBPaper00046904
        Curator_confirmed: WBPerson6532
      WBPhenotype:0001663 Paper_evidence: WBPaper00053621
        Curator_confirmed: WBPerson28450
    Phenotype_not_observed: WBPhenotype:0000030 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. C.P. Hunter: no growth defects at 20C Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000145 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. C.P. Hunter: no fertility defects at 20C Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
  Reference: WBPaper00042215
    WBPaper00032980
    WBPaper00046904
    WBPaper00053621
  Remark: 34358/34359-34993/34994 (635 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele