WormBase Tree Display for Gene: WBGene00000425

WBGene00000425 SMap: S_parent: Sequence: ZK512
  Identity: Version: 1
    Name: CGC_name: ced-11 Person_evidence: WBPerson261
      Sequence_name: ZK512.3
      Molecular_name: ZK512.3
        ZK512.3.1
        CE00409
      Other_name: CELE_ZK512.3 Accession_evidence: NDB BX284603
      Public_name: ced-11
    DB_info: Database: AceView gene 3K213
        WormQTL gene WBGene00000425
        WormFlux gene WBGene00000425
        NDB locus_tag CELE_ZK512.3
        Panther gene CAEEL|WormBase=WBGene00000425|UniProtKB=P34641
          family PTHR13800
        NCBI gene 176288
        RefSeq protein NM_066620.6
        SwissProt UniProtAcc P34641
        TREEFAM TREEFAM_ID TF321453
        UniProt_GCRP UniProtAcc P34641
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ced
    Allele (68)
    Legacy_information: [Stanfield G] abnormal programmed cell death corpses
      [C.elegansII] n2744 : abnormal programmed cell death corpses OA3: n2745, n2832, n2833, n2834Cloned: encodes predicted novel protein. [MT]
    RNASeq_FPKM (74)
    GO_annotation: 00043643
      00043644
      00043645
      00043646
      00043647
      00043648
    Ortholog (34)
    Paralog: WBGene00001651 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001795 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001796 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004149 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008731 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020972 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021404 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021408 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The ced-11 gene encodes a predicted transmembrane ion channel related to the long transient receptor potential channel (LTRPC) subfamily of TRP channels found in Drosophila and mammals; CED-11 functions as a downstream effector in the programmed cell death pathway and may play a role in affecting the morphological changes seen in the nucleus, cytoplasm, and plasma membrane of apoptotic cells. Paper_evidence: WBPaper00004159
            WBPaper00022068
            WBPaper00022724
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable monoatomic cation channel activity. Involved in apoptotic process. Predicted to be located in membrane. Expressed in apoptotic cell; head; hypodermis; and tail. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK512.3
    Corresponding_transcript: ZK512.3.1
    Other_sequence (14)
    Associated_feature: WBsf659389
      WBsf659390
      WBsf993579
      WBsf1015548
      WBsf225522
      WBsf225523
      WBsf225524
  Experimental_info: RNAi_result: WBRNAi00002366 Inferred_automatically: RNAi_primary
      WBRNAi00038317 Inferred_automatically: RNAi_primary
      WBRNAi00059472 Inferred_automatically: RNAi_primary
      WBRNAi00006142 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2040
      Expr13488
      Expr1011305
      Expr1030241
      Expr1162895
      Expr2009842
      Expr2028082
    Drives_construct: WBCnstr00037551
    Construct_product: WBCnstr00037551
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00041954:ethanol_upregulated
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049954:BPA_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050843:sesamin_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056446:hsb-1(cg116)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:ADL_parent
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:g1A_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:IL1_parent
      WBPaper00061340:M1_parent
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061340:Neuroblast_BAG_SMDVx
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:111_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      cgc4386_cluster_6_1
      WBPaper00025032:cluster_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031003:total_muscle_enriched
      WBPaper00031039:mtss-1(RNAi)_downregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(83_min)
    Interaction (11)
  Map_info: Map: III Position: 0.165457 Error: 0.00081
    Well_ordered
    Positive: Positive_clone: C33D7
        ZK512 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: C37G7
        ZK507
    Mapping_data: Multi_point: 2760
        2761
        2762
        2763
        2764
        2765
        2766
  Reference (16)
  Method: Gene