WormBase Tree Display for Gene: WBGene00000793
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| WBGene00000793 | Evidence | Accession_evidence | EMBL | AB081595 | |||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y41C4A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | crh-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | Y41C4A.4 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | CELE_Y41C4A.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | crh-1 | ||||||||
| DB_info | Database | AceView | gene | 3M781 | |||||
| WormQTL | gene | WBGene00000793 | |||||||
| WormFlux | gene | WBGene00000793 | |||||||
| NDB | locus_tag | CELE_Y41C4A.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000793|UniProtKB=D0Z5N1 | |||||||
| family | PTHR45879 | ||||||||
| NCBI | gene | 176597 | |||||||
| RefSeq | protein | NM_001027688.6 | |||||||
| NM_001027691.4 | |||||||||
| NM_001027690.4 | |||||||||
| NM_001268206.3 | |||||||||
| NM_001027689.3 | |||||||||
| NM_001027692.4 | |||||||||
| NM_001268207.3 | |||||||||
| SwissProt | UniProtAcc | Q9U2I0 | |||||||
| TREEFAM | TREEFAM_ID | TF106464 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U2I0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | crh | ||||||||
| Allele (986) | |||||||||
| Strain | WBStrain00040751 | ||||||||
| WBStrain00035398 | |||||||||
| WBStrain00055558 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00000222 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00002783 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016162 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | crh-1 encodes a homolog of the cyclic AMP-response element binding protein (CREB); crh-1 is involved in the transcription of CRE-sequence dependant genes activated by a CaM kinase cascade; crh-1 is required in the bilateral thermosensory neuron AFD, for a memory-related behaviour and for response to tap (nonlocalized mechanosensory stimulation) and tap habituation; crh-1 appears to be ubiquitously expressed. | Paper_evidence | WBPaper00005563 | |||||
| WBPaper00029055 | |||||||||
| WBPaper00039855 | |||||||||
| WBPaper00039821 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 02 Dec 2013 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity and transcription coactivator binding activity. Involved in determination of adult lifespan; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in several structures, including germ line; gonad; head ganglion; intestine; and neurons. Human ortholog(s) of this gene implicated in Pick's disease and schizophrenia. Is an ortholog of human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2345) | ||||
| DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2345) | ||||||
| DOID:11870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2345) | ||||||
| DOID:9975 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2345) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2345) | ||||||
| Molecular_info | Corresponding_CDS | Y41C4A.4a | |||||||
| Y41C4A.4b | |||||||||
| Y41C4A.4c | |||||||||
| Y41C4A.4d | |||||||||
| Y41C4A.4e | |||||||||
| Y41C4A.4f | |||||||||
| Y41C4A.4g | |||||||||
| Corresponding_CDS_history | Y41C4A.4a:wp89 | ||||||||
| Y41C4A.4b:wp89 | |||||||||
| Y41C4A.4c:wp89 | |||||||||
| Corresponding_transcript | Y41C4A.4a.1 | ||||||||
| Y41C4A.4b.1 | |||||||||
| Y41C4A.4c.1 | |||||||||
| Y41C4A.4d.1 | |||||||||
| Y41C4A.4e.1 | |||||||||
| Y41C4A.4f.1 | |||||||||
| Y41C4A.4g.1 | |||||||||
| Other_sequence (69) | |||||||||
| Associated_feature (43) | |||||||||
| Transcription_factor | WBTranscriptionFactor000257 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00056358 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00095782 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006490 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116042 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056360 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00087890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006495 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00008257 | ||||||||
| WBCnstr00012859 | |||||||||
| WBCnstr00038398 | |||||||||
| WBCnstr00038399 | |||||||||
| WBCnstr00041558 | |||||||||
| Construct_product (13) | |||||||||
| Regulate_expr_cluster | WBPaper00038172:crh-1null_down_regulated | ||||||||
| WBPaper00038172:crh-1null_up_regulated | |||||||||
| WBPaper00059816:crh-1(n3315)_downrgulated | |||||||||
| WBPaper00059816:crh-1(n3315)_uprgulated | |||||||||
| WBPaper00062440:crh-1(n3315)_downregulated | |||||||||
| WBPaper00062440:crh-1(n3315)_upregulated | |||||||||
| WBPaper00062440:crh-1(syb385)_downregulated | |||||||||
| WBPaper00062440:crh-1(syb385)_upregulated | |||||||||
| Antibody | WBAntibody00001853 | ||||||||
| Microarray_results (61) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (63) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | III | Position | 11.752 | Error | 0.036866 | |||
| Positive | Positive_clone | Y41C4A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4239 | |||||||
| 4497 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (94) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
