WormBase Tree Display for Gene: WBGene00001086
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WBGene00001086 | SMap | S_parent | Sequence | R13G10 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | dpy-27 | Person_evidence | WBPerson261 | |||||
Sequence_name | R13G10.1 | ||||||||
Molecular_name | R13G10.1 | ||||||||
R13G10.1.1 | |||||||||
CE01052 | |||||||||
Other_name | CELE_R13G10.1 | Accession_evidence | NDB | BX284603 | |||||
Public_name | dpy-27 | ||||||||
DB_info | Database | AceView | gene | 3E904 | |||||
WormQTL | gene | WBGene00001086 | |||||||
WormFlux | gene | WBGene00001086 | |||||||
NDB | locus_tag | CELE_R13G10.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00001086|UniProtKB=P48996 | |||||||
family | PTHR43939 | ||||||||
NCBI | gene | 175492 | |||||||
RefSeq | protein | NM_065370.7 | |||||||
SwissProt | UniProtAcc | P48996 | |||||||
TREEFAM | TREEFAM_ID | TF101158 | |||||||
UniProt_GCRP | UniProtAcc | P48996 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | dpy | ||||||||
Reference_allele | WBVar00275305 | ||||||||
Allele (91) | |||||||||
Legacy_information | rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). NA1. | ||||||||
[C.elegansII] rh18mat : XX phenotype is zygotic weak dumpy maternal effect dumpy/near lethal like Dpy-26 but non-Him. ES2. XO phenotype nearly wildtype male (ME3). OA5: y57 (weaker allele), y44, y42, y56am, y49 (strongest allele). Cloned: encodes 1469 aa protein with similarities to chromosome structural proteins, specifically localized to X chromosomes in XX but not XO animals. [Plenefisch et al. 1989; Chuang et al. 1994] | |||||||||
Strain | WBStrain00004518 | ||||||||
WBStrain00004680 | |||||||||
WBStrain00006374 | |||||||||
WBStrain00029961 | |||||||||
WBStrain00051718 | |||||||||
WBStrain00054734 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (37) | |||||||||
Paralog | WBGene00004874 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00001830 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00001860 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00003367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00004873 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00010306 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00012198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00016172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00019087 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00044079 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | dpy-27 encodes an ATP-binding protein that is a homolog of the SMC4 subunit of mitotic condensin; DPY-27, in combination with other proteins including MIX-1, act as a unit to repress X-linked gene expression during hermaphrodite dosage compensation; in XX oocytes and early embryos, DPY-27 exhibits diffuse nuclear localization, but by the 30-cell stage of embryogenesis, DPY-27 specifically localizes to X chromosomes; in XO animals at all stages, DPY-27 remains diffusely nuclear; the sex-specific localization of DPY-27 to X chromosomes is dependent upon wild-type activity of xol-1, as DPY-27 mislocalizes to the X chromosome of XO embryos in a xol-1 mutant background. | Paper_evidence | WBPaper00002061 | |||||
WBPaper00005173 | |||||||||
WBPaper00005215 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 14 Mar 2006 00:00:00 | ||||||||
Automated_description | Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | R13G10.1 | |||||||
Corresponding_transcript | R13G10.1.1 | ||||||||
Other_sequence | FD516123.1 | ||||||||
GO250655.1 | |||||||||
SR04997 | |||||||||
BXC07601_1 | |||||||||
CSC01057_1 | |||||||||
MJC03833_1 | |||||||||
MJ04686 | |||||||||
Associated_feature (15) | |||||||||
Gene_product_binds (205) | |||||||||
Transcription_factor | WBTranscriptionFactor000139 | ||||||||
Experimental_info | RNAi_result (26) | ||||||||
Expr_pattern | Expr1534 | ||||||||
Expr4351 | |||||||||
Expr8708 | |||||||||
Expr1013736 | |||||||||
Expr1030691 | |||||||||
Expr1155578 | |||||||||
Expr1200092 | |||||||||
Expr2011068 | |||||||||
Expr2029305 | |||||||||
Drives_construct | WBCnstr00020708 | ||||||||
WBCnstr00037089 | |||||||||
Construct_product | WBCnstr00016736 | ||||||||
WBCnstr00020708 | |||||||||
WBCnstr00037089 | |||||||||
Regulate_expr_cluster | WBPaper00050193:dpy-27(RNAi)_downregulated_L1 | ||||||||
WBPaper00050193:dpy-27(RNAi)_upregulated_L1 | |||||||||
Antibody | WBAntibody00000633 | ||||||||
WBAntibody00000970 | |||||||||
WBAntibody00001231 | |||||||||
WBAntibody00001460 | |||||||||
WBAntibody00001592 | |||||||||
WBAntibody00001731 | |||||||||
WBAntibody00001961 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (148) | |||||||||
Interaction (183) | |||||||||
WBProcess | WBbiopr:00000056 | ||||||||
WBbiopr:00000099 | |||||||||
Map_info | Map | III | Position | -4.25151 | Error | 0.000409 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C17A5 | |||||||
R13G10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 1612 | |||||||
Multi_point (7) | |||||||||
Pos_neg_data | 4706 | ||||||||
Reference (135) | |||||||||
Method | Gene |