WormBase Tree Display for Gene: WBGene00002232
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| WBGene00002232 | SMap | S_parent | Sequence | F11A6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | kpc-1 | Person_evidence | WBPerson533 | |||||
| Sequence_name | F11A6.1 | ||||||||
| Molecular_name | F11A6.1a | ||||||||
| F11A6.1a.1 | |||||||||
| CE17653 | |||||||||
| F11A6.1a.2 | |||||||||
| F11A6.1b | |||||||||
| Other_name | CELE_F11A6.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | kpc-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kpc | ||||||||
| Allele (115) | |||||||||
| Strain | WBStrain00035504 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (48) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | |||||
| WBPaper00018607 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | ||||
| DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | ||||||
| Molecular_info | Corresponding_CDS | F11A6.1a | |||||||
| Corresponding_CDS_history | F11A6.1b:wp245 | ||||||||
| Corresponding_transcript | F11A6.1b | ||||||||
| F11A6.1a.1 | |||||||||
| F11A6.1a.2 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003363 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089035 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106792 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044358 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027714 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00018109 | ||||||||
| WBCnstr00018110 | |||||||||
| WBCnstr00020063 | |||||||||
| Construct_product | WBCnstr00018110 | ||||||||
| WBCnstr00018228 | |||||||||
| WBCnstr00019277 | |||||||||
| WBCnstr00043014 | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (198) | |||||||||
| Interaction | WBInteraction000133161 | ||||||||
| WBInteraction000162394 | |||||||||
| WBInteraction000166779 | |||||||||
| WBInteraction000166852 | |||||||||
| WBInteraction000166853 | |||||||||
| WBInteraction000166859 | |||||||||
| WBInteraction000166860 | |||||||||
| WBInteraction000166861 | |||||||||
| WBInteraction000167330 | |||||||||
| WBInteraction000170022 | |||||||||
| WBInteraction000172856 | |||||||||
| WBInteraction000185153 | |||||||||
| WBInteraction000206435 | |||||||||
| WBInteraction000223627 | |||||||||
| WBInteraction000237661 | |||||||||
| WBInteraction000245059 | |||||||||
| WBInteraction000260436 | |||||||||
| WBInteraction000287768 | |||||||||
| WBInteraction000312285 | |||||||||
| WBInteraction000340768 | |||||||||
| WBInteraction000342791 | |||||||||
| WBInteraction000392789 | |||||||||
| WBInteraction000464760 | |||||||||
| WBInteraction000466161 | |||||||||
| WBInteraction000466162 | |||||||||
| WBInteraction000470682 | |||||||||
| WBInteraction000473507 | |||||||||
| WBInteraction000520503 | |||||||||
| WBInteraction000585307 | |||||||||
| Map_info | Map | I | Position | 9.53611 | Error | 0.019245 | |||
| Positive | Positive_clone | F11A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4460 | |||||||
| 4467 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
