WormBase Tree Display for Gene: WBGene00003100
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| WBGene00003100 | SMap | S_parent | Sequence | Y53C12B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mab-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y53C12B.5 | ||||||||
| Molecular_name | Y53C12B.5a | ||||||||
| Y53C12B.5a.1 | |||||||||
| CE14902 | |||||||||
| Y53C12B.5b | |||||||||
| CE51560 | |||||||||
| Y53C12B.5b.1 | |||||||||
| Y53C12B.5b.2 | |||||||||
| Other_name | CELE_Y53C12B.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mab-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mab | ||||||||
| Reference_allele | WBVar00143854 | ||||||||
| Allele (128) | |||||||||
| Legacy_information | e1240 : adult male tail morphology grossly abnormal often with hermaphrodite tail spike; adult male synthesizes yolk proteins; V and possibly other male lineages abnormal. ES3 (adult male) ME0. Hermaphrodite phenotype is wildtype. NA5 (e1921ts e2093 (similar but slightly weaker phenotypes than e1240)). | ||||||||
| See also e1240, e1921, e2093 | |||||||||
| [C.elegansII] e1240 : adult male tail morphology grossly abnormal, often with hermaphrodite tail spike; adult male synthesizes yolk proteins; V lineages abnormal, other defects. ES3 (adult male), ME0. Hermaphrodite WT.OA4: e1921ts, e2093 (similar but slightly weaker phenotypes than e1240), e2093, e2212. [Shen and Hodgkin 1988; CB] | |||||||||
| Strain | WBStrain00004394 | ||||||||
| WBStrain00004437 | |||||||||
| WBStrain00004807 | |||||||||
| WBStrain00006448 | |||||||||
| WBStrain00029934 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00007776 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00017326 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00007929 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00022060 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007058 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019521 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003114 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012832 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020708 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mab-3 encodes a DM (Doublesex and MAB-3) domain-containing protein; during development, MAB-3 plays a role in several aspects of male development; specifically, genetic studies indicate that MAB-3 likely augments the functions of the MAB-5 and EGL-5 homeodomain proteins by acting as a transcriptional repressor of ref-1, which encodes a basic helix-loop-helix (bHLH) protein that negatively regulates expression of the LIN-32 proneural bHLH protein required for male sensory ray development; in addition, MAB-3 regulates yolk protein expression in the intestine; mab-3 expression in the intestine is negatively regulated by TRA-1A, the terminal protein in the sex determination pathway; a mab-3::GFP promoter fusion is expressed in neurons and hypodermal cells as well as in the intestine; expression of the male-specific form of Drosophila Doublesex can rescue mab-3-related defects in C. elegans. | Paper_evidence | WBPaper00001076 | |||||
| WBPaper00003000 | |||||||||
| WBPaper00004324 | |||||||||
| WBPaper00025236 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ADF; SMD; and in male. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y53C12B.5a | |||||||
| Y53C12B.5b | |||||||||
| Corresponding_CDS_history | Y53C12B.5b:wp253 | ||||||||
| Corresponding_transcript | Y53C12B.5a.1 | ||||||||
| Y53C12B.5b.1 | |||||||||
| Y53C12B.5b.2 | |||||||||
| Other_sequence | Dviv_isotig08806 | ||||||||
| Dviv_isotig08805 | |||||||||
| Oden_isotig19447 | |||||||||
| Associated_feature (16) | |||||||||
| Gene_product_binds | WBsf977964 | ||||||||
| Transcription_factor | WBTranscriptionFactor000032 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00020914 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00057258 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027798 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr950 | ||||||||
| Expr3376 | |||||||||
| Expr14651 | |||||||||
| Expr1023078 | |||||||||
| Expr1160695 | |||||||||
| Expr2013327 | |||||||||
| Expr2031559 | |||||||||
| Drives_construct | WBCnstr00000514 | ||||||||
| WBCnstr00013819 | |||||||||
| WBCnstr00036229 | |||||||||
| Construct_product | WBCnstr00007577 | ||||||||
| WBCnstr00013819 | |||||||||
| WBCnstr00036229 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (131) | |||||||||
| Map_info | Map | II | Position | 1.70477 | Error | 0.004625 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf21 | |||||||
| Positive_clone | Y53C12B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 337 | |||||||
| Multi_point | 206 | ||||||||
| 1059 | |||||||||
| 4543 | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (118) | |||||||||
| Remark | sequence link from jah 980604 | ||||||||
| (a) removed from sequence. only .5 in sequence list. [sdm 05/00] | |||||||||
| Method | Gene |
