WormBase Tree Display for Gene: WBGene00003397
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| WBGene00003397 | SMap | S_parent | Sequence | T23D8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mom-5 | Person_evidence | WBPerson498 | |||||
| Sequence_name | T23D8.1 | ||||||||
| Molecular_name | T23D8.1a | ||||||||
| T23D8.1a.1 | |||||||||
| CE14048 | |||||||||
| T23D8.1b | |||||||||
| CE50472 | |||||||||
| T23D8.1b.1 | |||||||||
| Other_name | CELE_T23D8.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mom-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mom | ||||||||
| Allele (45) | |||||||||
| Possibly_affected_by | WBVar02153196 | ||||||||
| WBVar02153197 | |||||||||
| Legacy_information | [Rocheleau CE] zu193 is a Tc1 insertion: homozygotes are Mel, producing embryos that lack endoderm, overproduce pharyngeal tissue. mom-5 encodes a Frizzled-related protein, predicted gene T23D8.1 | ||||||||
| Strain | WBStrain00036921 | ||||||||
| WBStrain00007264 | |||||||||
| WBStrain00007281 | |||||||||
| WBStrain00007282 | |||||||||
| WBStrain00008495 | |||||||||
| WBStrain00008499 | |||||||||
| WBStrain00008500 | |||||||||
| WBStrain00008502 | |||||||||
| WBStrain00024212 | |||||||||
| WBStrain00024331 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (68) | |||||||||
| Ortholog (64) | |||||||||
| Paralog | WBGene00000478 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00003006 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003238 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022242 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mom-5 encodes one of four C. elegans members of the Frizzled (Fz) family of seven transmembrane receptors; during development, MOM-5 activity is required for asymmetric cell division in the early embryo and during neuronal development, and for attachment of the pharynx to the buccal cavity; MOM-5 is also required for distal tip cell migration in the gonad and for the engulfment of apoptotic cells, indicating that the Wnt pathway signals to CED-10/Rac to regulate cytoskeletal rearrangement during different cellular processes; MOM-5::GFP is enriched at the posterior pole of cells prior to division and during later stages of embryogenesis, is found at the leading edges of epidermal cells during ventral enclosure; in neuroblasts, MOM-5 is required for proper subcellular distribution of DSH-2 to the cortex. | Paper_evidence | WBPaper00002870 | |||||
| WBPaper00002871 | |||||||||
| WBPaper00024672 | |||||||||
| WBPaper00026633 | |||||||||
| WBPaper00035874 | |||||||||
| WBPaper00040399 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 16 Nov 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including embryonic morphogenesis; neuron migration; and regulation of locomotion. Predicted to be located in plasma membrane. Expressed in several structures, including QL.a; anus; gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; nonsyndromic congenital nail disorder 1; and omodysplasia 2. Is an ortholog of human FZD1 (frizzled class receptor 1); FZD2 (frizzled class receptor 2); and FZD7 (frizzled class receptor 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2154 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4045) | ||||
| DOID:1928 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4041) | ||||||
| DOID:0080079 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4044) | ||||||
| DOID:0080845 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4040) | ||||||
| DOID:127 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4040) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4038,HGNC:4040) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4041) | ||||||
| Molecular_info | Corresponding_CDS | T23D8.1a | |||||||
| T23D8.1b | |||||||||
| Corresponding_transcript | T23D8.1a.1 | ||||||||
| T23D8.1b.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf218375 | ||||||||
| Experimental_info | RNAi_result (105) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00012006 | ||||||||
| WBCnstr00018479 | |||||||||
| WBCnstr00018481 | |||||||||
| WBCnstr00019045 | |||||||||
| WBCnstr00020822 | |||||||||
| WBCnstr00036139 | |||||||||
| Construct_product | WBCnstr00005215 | ||||||||
| WBCnstr00019049 | |||||||||
| WBCnstr00020002 | |||||||||
| WBCnstr00036139 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (165) | |||||||||
| Anatomy_function | WBbtf0748 | ||||||||
| WBbtf0962 | |||||||||
| WBProcess | WBbiopr:00000023 | ||||||||
| WBbiopr:00000073 | |||||||||
| WBbiopr:00000112 | |||||||||
| Map_info | Map | I | Position | 4.11985 | Error | 0.003474 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | qDf9 | |||||||
| qDf10 | |||||||||
| Positive_clone | T23D8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Multi_point | 3633 | |||||||
| 5544 | |||||||||
| 5650 | |||||||||
| Pos_neg_data | 10555 | ||||||||
| 10557 | |||||||||
| Reference (120) | |||||||||
| Remark | Data extracted from Rocheleau et al. (1997), Thorpe et al. (1997) | ||||||||
| Method | Gene |
