WormBase Tree Display for Gene: WBGene00004729
expand all nodes | collapse all nodes | view schema
WBGene00004729 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | sax-3 | Person_evidence | WBPerson42 | |||||
Sequence_name | ZK377.2 | ||||||||
Molecular_name | ZK377.2a | ||||||||
ZK377.2a.1 | |||||||||
CE25688 | |||||||||
ZK377.2b | |||||||||
CE31267 | |||||||||
ZK377.2b.1 | |||||||||
Other_name | CELE_ZK377.2 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sax-3 | ||||||||
DB_info | Database | AceView | gene | XE72 | |||||
WormQTL | gene | WBGene00004729 | |||||||
WormFlux | gene | WBGene00004729 | |||||||
NDB | locus_tag | CELE_ZK377.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004729|UniProtKB=G5EBF1 | |||||||
family | PTHR11640 | ||||||||
NCBI | gene | 180637 | |||||||
RefSeq | protein | NM_171652.8 | |||||||
NM_001029819.7 | |||||||||
SwissProt | UniProtAcc | G5EBF1 | |||||||
TREEFAM | TREEFAM_ID | TF351053 | |||||||
UniProt_GCRP | UniProtAcc | G5EBF1 | |||||||
OMIM | gene | 602430 | |||||||
602431 | |||||||||
608630 | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303098 | ||||
Split_into | WBGene00303098 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sax | ||||||||
Allele (171) | |||||||||
Legacy_information | [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2 | ||||||||
Strain (11) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (50) | |||||||||
Paralog (22) | |||||||||
Structured_description | Concise_description | sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. | Paper_evidence | WBPaper00003665 | |||||
WBPaper00004362 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 24 Jan 2008 00:00:00 | ||||||||
Automated_description | Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (11) | ||||||||
Molecular_info | Corresponding_CDS | ZK377.2a | |||||||
ZK377.2b | |||||||||
Corresponding_CDS_history | ZK377.2c:wp264 | ||||||||
Corresponding_transcript | ZK377.2a.1 | ||||||||
ZK377.2b.1 | |||||||||
Other_sequence (32) | |||||||||
Associated_feature (39) | |||||||||
Experimental_info | RNAi_result | WBRNAi00086088 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086133 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009468 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009467 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067130 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00059385 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (17) | |||||||||
Drives_construct | WBCnstr00001914 | ||||||||
WBCnstr00003185 | |||||||||
WBCnstr00006455 | |||||||||
WBCnstr00009445 | |||||||||
WBCnstr00012503 | |||||||||
WBCnstr00016209 | |||||||||
WBCnstr00035424 | |||||||||
WBCnstr00039977 | |||||||||
WBCnstr00041184 | |||||||||
Construct_product (15) | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (134) | |||||||||
Interaction (262) | |||||||||
Anatomy_function | WBbtf0177 | ||||||||
Map_info | Map | X | Position | -10.3398 | Error | 0.007528 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDp57 | |||||||
Positive_clone | R06A1 | ||||||||
ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 3695 | |||||||
3696 | |||||||||
4758 | |||||||||
Pos_neg_data | 9401 | ||||||||
Reference | WBPaper00002991 | ||||||||
WBPaper00002997 | |||||||||
WBPaper00003665 | |||||||||
WBPaper00003674 | |||||||||
WBPaper00003760 | |||||||||
WBPaper00003949 | |||||||||
WBPaper00004362 | |||||||||
WBPaper00004695 | |||||||||
WBPaper00004900 | |||||||||
WBPaper00005236 | |||||||||
WBPaper00005237 | |||||||||
WBPaper00005251 | |||||||||
WBPaper00005544 | |||||||||
WBPaper00005719 | |||||||||
WBPaper00005760 | |||||||||
WBPaper00006025 | |||||||||
WBPaper00006052 | |||||||||
WBPaper00006185 | |||||||||
WBPaper00006288 | |||||||||
WBPaper00006471 | |||||||||
WBPaper00010168 | |||||||||
WBPaper00011128 | |||||||||
WBPaper00012380 | |||||||||
WBPaper00013450 | |||||||||
WBPaper00015626 | |||||||||
WBPaper00015717 | |||||||||
WBPaper00016704 | |||||||||
WBPaper00017099 | |||||||||
WBPaper00017383 | |||||||||
WBPaper00017429 | |||||||||
WBPaper00017433 | |||||||||
WBPaper00017704 | |||||||||
WBPaper00017711 | |||||||||
WBPaper00017712 | |||||||||
WBPaper00018333 | |||||||||
WBPaper00018335 | |||||||||
WBPaper00018572 | |||||||||
WBPaper00018582 | |||||||||
WBPaper00018588 | |||||||||
WBPaper00018942 | |||||||||
WBPaper00019306 | |||||||||
WBPaper00019311 | |||||||||
WBPaper00022845 | |||||||||
WBPaper00022847 | |||||||||
WBPaper00023013 | |||||||||
WBPaper00023085 | |||||||||
WBPaper00023161 | |||||||||
WBPaper00023199 | |||||||||
WBPaper00023310 | |||||||||
WBPaper00023315 | |||||||||
WBPaper00023401 | |||||||||
WBPaper00023980 | |||||||||
WBPaper00024140 | |||||||||
WBPaper00024195 | |||||||||
WBPaper00024484 | |||||||||
WBPaper00024524 | |||||||||
WBPaper00024525 | |||||||||
WBPaper00024722 | |||||||||
WBPaper00024939 | |||||||||
WBPaper00026115 | |||||||||
WBPaper00026148 | |||||||||
WBPaper00026343 | |||||||||
WBPaper00026416 | |||||||||
WBPaper00026439 | |||||||||
WBPaper00026680 | |||||||||
WBPaper00026825 | |||||||||
WBPaper00026845 | |||||||||
WBPaper00026866 | |||||||||
WBPaper00027119 | |||||||||
WBPaper00027206 | |||||||||
WBPaper00027335 | |||||||||
WBPaper00027618 | |||||||||
WBPaper00027646 | |||||||||
WBPaper00028085 | |||||||||
WBPaper00028566 | |||||||||
WBPaper00029024 | |||||||||
WBPaper00029052 | |||||||||
WBPaper00029053 | |||||||||
WBPaper00030317 | |||||||||
WBPaper00031043 | |||||||||
WBPaper00031067 | |||||||||
WBPaper00031543 | |||||||||
WBPaper00031651 | |||||||||
WBPaper00031671 | |||||||||
WBPaper00031828 | |||||||||
WBPaper00032413 | |||||||||
WBPaper00032446 | |||||||||
WBPaper00032941 | |||||||||
WBPaper00033533 | |||||||||
WBPaper00034526 | |||||||||
WBPaper00035405 | |||||||||
WBPaper00036313 | |||||||||
WBPaper00037014 | |||||||||
WBPaper00037766 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00038504 | |||||||||
WBPaper00038663 | |||||||||
WBPaper00038670 | |||||||||
WBPaper00039166 | |||||||||
WBPaper00039177 | |||||||||
WBPaper00039204 | |||||||||
WBPaper00040041 | |||||||||
WBPaper00040048 | |||||||||
WBPaper00040235 | |||||||||
WBPaper00042082 | |||||||||
WBPaper00042510 | |||||||||
WBPaper00042766 | |||||||||
WBPaper00042977 | |||||||||
WBPaper00043290 | |||||||||
WBPaper00043374 | |||||||||
WBPaper00043453 | |||||||||
WBPaper00044158 | |||||||||
WBPaper00045899 | |||||||||
WBPaper00045955 | |||||||||
WBPaper00046690 | |||||||||
WBPaper00047484 | |||||||||
WBPaper00047772 | |||||||||
WBPaper00047944 | |||||||||
WBPaper00047958 | |||||||||
WBPaper00048281 | |||||||||
WBPaper00050480 | |||||||||
WBPaper00051142 | |||||||||
WBPaper00051935 | |||||||||
WBPaper00053739 | |||||||||
WBPaper00054187 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00055566 | |||||||||
WBPaper00055911 | |||||||||
WBPaper00056066 | |||||||||
WBPaper00056135 | |||||||||
WBPaper00056294 | |||||||||
WBPaper00056384 | |||||||||
WBPaper00056692 | |||||||||
WBPaper00056744 | |||||||||
WBPaper00060014 | |||||||||
WBPaper00060641 | |||||||||
WBPaper00061219 | |||||||||
WBPaper00063298 | |||||||||
WBPaper00063743 | |||||||||
WBPaper00064099 | |||||||||
WBPaper00064636 | |||||||||
WBPaper00064805 | |||||||||
WBPaper00065184 | |||||||||
Remark | Inferred from Zallen et al. (1998) | ||||||||
2 predicted genes (see phenotype) have been merged. [sdm 05/00] | |||||||||
Method | Gene |