| WBGene00004729 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | sax-3 | Person_evidence | WBPerson42 |
| | | Sequence_name | ZK377.2 |
| | | Molecular_name | ZK377.2a |
| | | | ZK377.2a.1 |
| | | | CE25688 |
| | | | ZK377.2b |
| | | | CE31267 |
| | | | ZK377.2b.1 |
| | | Other_name | CELE_ZK377.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | sax-3 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303098 |
| | | Split_into | WBGene00303098 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sax |
| | Allele (171) |
| | Legacy_information | [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2 |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog (50) |
| | Paralog (22) |
| | Structured_description | Concise_description | sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. | Paper_evidence | WBPaper00003665 |
| | | | | | WBPaper00004362 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 24 Jan 2008 00:00:00 |
| | | Automated_description | Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (11) |
| Molecular_info | Corresponding_CDS | ZK377.2a |
| | | ZK377.2b |
| | Corresponding_CDS_history | ZK377.2c:wp264 |
| | Corresponding_transcript | ZK377.2a.1 |
| | | ZK377.2b.1 |
| | Other_sequence (32) |
| | Associated_feature (39) |
| Experimental_info | RNAi_result | WBRNAi00086088 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086133 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009468 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009467 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067130 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059385 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (17) |
| | Drives_construct | WBCnstr00001914 |
| | | WBCnstr00003185 |
| | | WBCnstr00006455 |
| | | WBCnstr00009445 |
| | | WBCnstr00012503 |
| | | WBCnstr00016209 |
| | | WBCnstr00035424 |
| | | WBCnstr00039977 |
| | | WBCnstr00041184 |
| | Construct_product (15) |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00031132:LiCl_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SMD |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_19 |
| | | cgc4489_group_23 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (262) |
| | Anatomy_function | WBbtf0177 |
| Map_info | Map | X | Position | -10.3398 | Error | 0.007528 |
| | Well_ordered |
| | Positive | Inside_rearr | mnDp57 |
| | | Positive_clone | R06A1 |
| | | | ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3695 |
| | | | 3696 |
| | | | 4758 |
| | | Pos_neg_data | 9401 |
| Reference (143) |
| Remark | Inferred from Zallen et al. (1998) |
| | 2 predicted genes (see phenotype) have been merged. [sdm 05/00] |
| Method | Gene |
