WormBase Tree Display for Gene: WBGene00006755
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WBGene00006755 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00142966 | ||||||
Allele (140) | |||||||
Legacy_information | e109 : very sluggish small; males more active. ES3 ME2. NA1. | ||||||
See also e109 | |||||||
[Thomas JT ] Egl, Unc and defecation phenotypes, resembles Unc-16. | |||||||
n730ts : transient bloating at 25x Type C; uncoordinated sluggish weak coiler phenotype. ES3 (adult 25x) ES2 (other stages 25x). NA1. | |||||||
See also n730 | |||||||
[C.elegansII] e109 : very sluggish small; males more active. ES3 ME2. OA1: n730ts (pka egl-39, transient bloating at 25C; sensitive to serotonin and to imipramine; uncoordinated sluggish weak coiler phenotype. ES3 (adult 25C) ES2 (other stages 25C), ME2). [Brenner 1974; Trent et al. 1983; JT] | |||||||
Complementation_data | [Thomas JT ] n730 fails to complement unc-16(e109). | ||||||
Strain | WBStrain00023488 | ||||||
WBStrain00026866 | |||||||
WBStrain00004103 | |||||||
WBStrain00005379 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (34) | |||||||
Contained_in_operon | CEOP3830 | ||||||
Ortholog (47) | |||||||
Structured_description | Concise_description | unc-16 encodes a homolog of murine JIP3 (c-Jun N-terminal kinase (JNK)-interacting protein 3) and Drosophila SUNDAY DRIVER; unc-16 is involved in vesicle transport and mutations affect egg laying, locomotion, and defecation; UNC-16 physically interacts with JNK and JNK kinases, with the KLC-2 kinesin light chain, and the DLI-1 dynein light intermediate chain; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx. | Paper_evidence | WBPaper00000031 | |||
WBPaper00000635 | |||||||
WBPaper00001256 | |||||||
WBPaper00002315 | |||||||
WBPaper00005014 | |||||||
WBPaper00024617 | |||||||
WBPaper00038128 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 09 Mar 2011 00:00:00 | ||||||
Automated_description | Enables kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in several processes, including defecation; egg-laying behavior; and regulation of JNK cascade. Located in axon; cell body; and cytoplasm. Expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in endometrial cancer; hepatocellular carcinoma; and liver cirrhosis. Is an ortholog of human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||||
DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14524) | ||||
Molecular_info | Corresponding_CDS (16) | ||||||
Corresponding_CDS_history | ZK1098.10:wp84 | ||||||
Corresponding_transcript (17) | |||||||
Other_sequence (83) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result (19) | ||||||
Expr_pattern | Expr1778 | ||||||
Expr11021 | |||||||
Expr11973 | |||||||
Expr1013805 | |||||||
Expr1032829 | |||||||
Expr1162532 | |||||||
Expr2017851 | |||||||
Expr2035987 | |||||||
Drives_construct | WBCnstr00010435 | ||||||
Construct_product | WBCnstr00010435 | ||||||
WBCnstr00017645 | |||||||
Antibody | WBAntibody00002438 | ||||||
WBAntibody00003035 | |||||||
Microarray_results (60) | |||||||
Expression_cluster (122) | |||||||
SAGE_tag (23) | |||||||
Interaction (100) | |||||||
WBProcess | WBbiopr:00000010 | ||||||
Map_info | Map | III | Position | 0.58611 | Error | 0.010236 | |
Well_ordered | |||||||
Positive | Positive_clone | ZK1098 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 54 | |||||
83 | |||||||
Multi_point (19) | |||||||
Pos_neg_data | 8639 | ||||||
Reference (68) | |||||||
Remark | n730 previously known as egl-39. unc-16 chosen as preferred name by Thomas JT, Horvitz HR. | ||||||
Sequence connection from [Jin Y] | |||||||
Method | Gene |