WormBase Tree Display for Gene: WBGene00006763
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| WBGene00006763 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-26 | Person_evidence | WBPerson261 | |||||
| Sequence_name | JC8.10 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | unc-48 | ||||||||
| CELE_JC8.10 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | unc-26 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143035 | ||||||||
| Allele (250) | |||||||||
| Legacy_information | e205 : severe kinker small scrawny flaccid little movement; slow pharyngeal pumping. ES3 ME0 NA9 (e176 e345 (pka unc-48) etc. | ||||||||
| See unc-26. | |||||||||
| See also ad473, ad701, ad706, e205, e2340, n1307, s1710 | |||||||||
| [C.elegansII] e205amb : severe kinker, small, scrawny, flaccid little movement; slow pharyngeal pumping; Ric. ES3 ME0 OA>10: e176, e345 (pka unc-48), e314 (strong Exp, weak Unc, Eat), e2340, m2, n1307, s1710mut, ad473, ad701, etc. Some (5/18) alleles have expulsion defect in defecation. Gene is recombinationally large. [Charest et al. 1990; Avery 1993; DA; EG; JT; RM] | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Contained_in_operon | CEOP4539 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00012016 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00086546 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007620 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009264 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012353 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization. | Paper_evidence | WBPaper00004275 | |||||
| WBPaper00004637 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including cellular component organization; nitrogen compound transport; and regulation of locomotion. Located in synapse. Expressed in tail and ventral cord neurons. Used to study Down syndrome and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 20 and developmental and epileptic encephalopathy 53. Is an ortholog of human SYNJ1 (synaptojanin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00053600 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Mar 2018 00:00:00 | ||||||||
| DOID:0060894 | Homo sapiens | Paper_evidence | WBPaper00062416 | ||||||
| WBPaper00062681 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Jun 2022 00:00:00 | ||||||||
| Potential_model | DOID:0080464 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11503) | |||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11503) | ||||||
| DOID:0060898 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11503) | ||||||
| Modifies_disease | DOID:10652 | ||||||||
| Models_disease_in_annotation | WBDOannot00001244 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000724 | ||||||||
| Models_disease_asserted | WBDOannot00000491 | ||||||||
| WBDOannot00001221 | |||||||||
| Molecular_info | Corresponding_CDS | JC8.10a | |||||||
| JC8.10b | |||||||||
| JC8.10c | |||||||||
| JC8.10d | |||||||||
| Corresponding_CDS_history | JC8.10:wp53 | ||||||||
| Corresponding_transcript | JC8.10a.1 | ||||||||
| JC8.10b.1 | |||||||||
| JC8.10c.1 | |||||||||
| JC8.10d.1 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00001637 | ||||||||
| WBCnstr00002608 | |||||||||
| WBCnstr00002732 | |||||||||
| WBCnstr00004403 | |||||||||
| Construct_product (5) | |||||||||
| Antibody | WBAntibody00002627 | ||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | IV | Position | 8.51401 | Error | 0.001138 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf21 | |||||||
| nDp5 | |||||||||
| Positive_clone | JC8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | sDf22 | |||||||
| Mapping_data | 2_point | 21 | |||||||
| 116 | |||||||||
| 122 | |||||||||
| 142 | |||||||||
| 439 | |||||||||
| 1636 | |||||||||
| 7060 | |||||||||
| Multi_point (37) | |||||||||
| Pos_neg_data | 976 | ||||||||
| 983 | |||||||||
| 3812 | |||||||||
| 8180 | |||||||||
| 832 | |||||||||
| 4678 | |||||||||
| 4685 | |||||||||
| 4687 | |||||||||
| 798 | |||||||||
| Landmark_gene | |||||||||
| Reference (101) | |||||||||
| Method | Gene |
