| WBGene00006793 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | W09C5 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-59 | Person_evidence | WBPerson261 |
| | | Sequence_name | W09C5.2 |
| | | Molecular_name | W09C5.2 |
| | | | W09C5.2.1 |
| | | | CE20165 |
| | | Other_name | unc-88 |
| | | | CELE_W09C5.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-59 |
| | DB_info | Database | AceView | gene | 1O225 |
| | | | WormQTL | gene | WBGene00006793 |
| | | | WormFlux | gene | WBGene00006793 |
| | | | NDB | locus_tag | CELE_W09C5.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006793|UniProtKB=Q9U334 |
| | | | | family | PTHR18884 |
| | | | NCBI | gene | 173233 |
| | | | RefSeq | protein | NM_060987.6 |
| | | | TrEMBL | UniProtAcc | Q9U334 |
| | | | UniProt_GCRP | UniProtAcc | Q9U334 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143070 |
| | Allele (52) |
| | Legacy_information | e261 : poor backward movement forward better; thin; vulva variably abnormal often protrusive sometimes ruptured; many postembryonic lineage abnormalities resulting from variable failures in cytokinesis; gonad lineages sometimes defective; males have very abnormal tail anatomy. ES2 ME0. NA2 (e1005 (pka unc-88)). |
| | | See unc-59. |
| | | See also e1005, e1465, n391 |
| | | [C.elegansII] e261 : poor backward movement, forward better; thin; vulva variably abnormal, often protrusive, sometimes ruptured; many postembryonic lineage abnormalities resulting from variable failures in cytokinesis; gonad lineages sometimes defective; variable defects in neuroanatomy; males have very abnormal tail anatomy. ES2 ME0. OA3: e1005 (pka unc-88), e1465, n391. [Brenner 1974; White et al. 1982; MT] |
| | Strain | WBStrain00023968 |
| | | WBStrain00027078 |
| | | WBStrain00004226 |
| | | WBStrain00004137 |
| | | WBStrain00005472 |
| | | WBStrain00008449 |
| | | WBStrain00050769 |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (54) |
| | Paralog | WBGene00015956 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00006795 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-59, by alternative splicing, encodes two septin isoforms required (like the septins UNC-61A/B) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-59 and UNC-61A/B are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-59 and UNC-61A/B depend on each other for localization to the cytokinetic furrow. | Paper_evidence | WBPaper00000496 |
| | | | | | WBPaper00004453 |
| | | | | | WBPaper00006087 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 01 Feb 2006 00:00:00 |
| | | Automated_description | Predicted to enable GTPase activity and molecular adaptor activity. Involved in egg-laying behavior; locomotion; and post-embryonic development. Located in cleavage furrow and midbody. Expressed in several structures, including buccal cavity; distal tip cell; germ line; pharynx; and sperm. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Is an ortholog of human SEPTIN7 (septin 7). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9165) |
| | | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9165) |
| Molecular_info | Corresponding_CDS | W09C5.2 |
| | Corresponding_transcript | W09C5.2.1 |
| | Other_sequence (38) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (38) |
| | Expr_pattern | Expr2318 |
| | | Expr2691 |
| | | Expr3284 |
| | | Expr14682 |
| | | Expr1015124 |
| | | Expr1032863 |
| | | Expr1158568 |
| | | Expr2017891 |
| | | Expr2036027 |
| | Drives_construct | WBCnstr00010902 |
| | Construct_product | WBCnstr00005646 |
| | | WBCnstr00010902 |
| | Antibody | WBAntibody00000329 |
| | | WBAntibody00000930 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058958:100mGy-irradiation-72h_downregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:ima-1_20458-bath-41 |
| | | WBPaper00061651:Distal_tip_cell_enriched |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062456:doxycycline_downregulated_N2_protein |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:1_2 |
| | | WBPaper00065841:7_4 |
| | | WBPaper00065841:31_0 |
| | | WBPaper00065841:57_1 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037695:LD_DD_6-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00040963:TA100_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (77) |
| Map_info | Map | I | Position | 21.6174 | Error | 0.007359 |
| | Well_ordered |
| | Positive | Positive_clone | W09C5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 22 |
| | | | 24 |
| | | | 30 |
| | | | 33 |
| | | Multi_point (14) |
| | | Pos_neg_data (14) |
| | Landmark_gene |
| Reference (49) |
| Remark | Sequence connection from [Nguyen TQ, White JG] |
| Method | Gene |
