WormBase Tree Display for Gene: WBGene00006798
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| WBGene00006798 | SMap | S_parent | Sequence | F56A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-64 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F56A8.7 | ||||||||
| Molecular_name | F56A8.7a | ||||||||
| F56A8.7a.1 | |||||||||
| CE16127 | |||||||||
| F56A8.7b | |||||||||
| CE28035 | |||||||||
| F56A8.7a.2 | |||||||||
| F56A8.7b.1 | |||||||||
| Other_name | syx-1 | Person_evidence | WBPerson3132 | ||||||
| CELE_F56A8.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-64 | ||||||||
| DB_info | Database | AceView | gene | 3O371 | |||||
| WormQTL | gene | WBGene00006798 | |||||||
| WormFlux | gene | WBGene00006798 | |||||||
| NDB | locus_tag | CELE_F56A8.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006798|UniProtKB=O16000 | |||||||
| family | PTHR19957 | ||||||||
| NCBI | gene | 176743 | |||||||
| RefSeq | protein | NM_001027443.6 | |||||||
| NM_001379980.1 | |||||||||
| SwissProt | UniProtAcc | O16000 | |||||||
| UniProt_GCRP | UniProtAcc | O16000 | |||||||
| OMIM | gene | 600876 | |||||||
| 601485 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Apr 2010 14:03:06 | WBPerson2970 | Name_change | Other_name | syx-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143062 | ||||||||
| Allele (105) | |||||||||
| Legacy_information | e246 : sluggish will move either forward or backward if prodded but almost immediately jams up; partially lannate resistant; healthy. ES2 ME0. NA1. | ||||||||
| See also e246 | |||||||||
| [C.elegansII] e246 : sluggish, will move either forward or backward if prodded but almost immediately jams up; Ric; healthy; elevated acetylcholine levels. ES2 ME0. OA>1 (some alleles lead to severe paralysis). Cloned: encodes predicted syntaxin homolog. [Brenner 1974; Nguyen et al. 1995; NM; RM; TN] | |||||||||
| [Ogawa H, Hosono R] e246 is A248V, in predicted 291aa syntaxin homologue, 63% identical to human syntaxin. unc-64::GFP expressed extensively in neurons. Predicted gene F56A8.7 | |||||||||
| Strain | WBStrain00026467 | ||||||||
| WBStrain00029044 | |||||||||
| WBStrain00029049 | |||||||||
| WBStrain00030888 | |||||||||
| WBStrain00004366 | |||||||||
| WBStrain00004134 | |||||||||
| WBStrain00007239 | |||||||||
| WBStrain00055180 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00006371 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006372 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006373 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006374 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00012150 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009478 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022534 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-64 encodes syntaxin, a plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 trafficking from the endoplasmic reticulum to the plasma membrane is mediated by UNC-18, an SM (Sec1, Munc18) family member; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the vulval uv1 cell and the excretory gland cells. | Paper_evidence | WBPaper00003101 | |||||
| WBPaper00005015 | |||||||||
| WBPaper00005528 | |||||||||
| WBPaper00006124 | |||||||||
| WBPaper00031990 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Nov 2008 00:00:00 | ||||||||
| Automated_description | Enables protein-folding chaperone binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Located in axon; basolateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory gland cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including Creutzfeldt-Jakob disease; Hirschsprung's disease; and generalized epilepsy with febrile seizures plus 9. Is an ortholog of human STX1A (syntaxin 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11949 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11433) | ||||
| DOID:10487 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11433) | ||||||
| DOID:0111301 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18539) | ||||||
| DOID:0060774 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11438) | ||||||
| Molecular_info | Corresponding_CDS | F56A8.7a | |||||||
| F56A8.7b | |||||||||
| Corresponding_transcript | F56A8.7a.1 | ||||||||
| F56A8.7a.2 | |||||||||
| F56A8.7b.1 | |||||||||
| Other_sequence (58) | |||||||||
| Associated_feature | WBsf659704 | ||||||||
| WBsf659705 | |||||||||
| WBsf659706 | |||||||||
| WBsf718014 | |||||||||
| WBsf994847 | |||||||||
| WBsf225978 | |||||||||
| WBsf225979 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000180 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (203) | |||||||||
| Map_info | Map | III | Position | 21.1995 | Error | 0.007471 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf2 | |||||||
| eDp6 | |||||||||
| ctDf2 | |||||||||
| Positive_clone | B0502 | ||||||||
| C26A4 | |||||||||
| F56A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | tDf10 | |||||||
| Mapping_data (3) | |||||||||
| Landmark_gene | |||||||||
| Reference (197) | |||||||||
| Remark | Data extracted from Ogawa et al. (1998) | ||||||||
| Method | Gene |
