WormBase Tree Display for Gene: WBGene00006819
expand all nodes | collapse all nodes | view schema
WBGene00006819 | Evidence | Paper_evidence | WBPaper00002036 | ||||
---|---|---|---|---|---|---|---|
WBPaper00004578 | |||||||
SMap | S_parent | Sequence | F08B6 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143839 | ||||||
Allele (67) | |||||||
Legacy_information | e1216 : limp paralysed or very sluggish; somewhat Egl; larvae more paralysed; abnormal body muscle birefringence and ultrastructure thin filaments in small bundles. ES3 ME0. NA > 10 (e1459amber (phenotype more severe than e1216) st39 r320 etc.). | ||||||
See also e1216 | |||||||
[C.elegansII] e1216 : limp paralysed or very sluggish; somewhat Egl; larvae more paralysed; abnormal body muscle birefringence and ultrastructure, thin filaments in small bundles. ES3 ME0. OA>10: e1459amb (phenotype more severe than e1216), st39 r320 etc. Cloned: encodes predicted 40 kD protein with similarities to vertebrate smooth muscle proteins calponin, Drosophila mp20; localized to I bands. Alternative splicing. [Waterston et al. 1980; Goetinck and Waterston 1994;RW] | |||||||
Strain | WBStrain00027141 | ||||||
WBStrain00033504 | |||||||
WBStrain00033505 | |||||||
WBStrain00004273 | |||||||
WBStrain00004336 | |||||||
WBStrain00006225 | |||||||
WBStrain00006264 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (24) | |||||||
Ortholog (31) | |||||||
Paralog | WBGene00000777 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000778 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00019361 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00020808 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00016898 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000779 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000780 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments. | Paper_evidence | WBPaper00002035 | |||
WBPaper00002036 | |||||||
WBPaper00004578 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and myosin binding activity. Involved in actin cytoskeleton organization and negative regulation of muscle filament sliding. Located in I band; stress fiber; and striated muscle thin filament. Part of actomyosin, myosin complex part. Expressed in several structures, including non-striated muscle; pharynx; spermatheca; ventral ganglion; and vulva. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F08B6.4a | |||||
F08B6.4b | |||||||
Corresponding_CDS_history | F08B6.4c:wp248 | ||||||
Corresponding_transcript | F08B6.4a.1 | ||||||
F08B6.4b.1 | |||||||
Other_sequence (447) | |||||||
Associated_feature | WBsf983993 | ||||||
WBsf983994 | |||||||
WBsf983995 | |||||||
WBsf219635 | |||||||
WBsf219636 | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern | Expr2746 | ||||||
Expr4808 | |||||||
Expr4809 | |||||||
Expr12512 | |||||||
Expr12513 | |||||||
Expr1015918 | |||||||
Expr1032884 | |||||||
Expr1147950 | |||||||
Expr2017916 | |||||||
Expr2036052 | |||||||
Drives_construct | WBCnstr00021434 | ||||||
WBCnstr00021435 | |||||||
WBCnstr00034137 | |||||||
Construct_product | WBCnstr00034137 | ||||||
Antibody | WBAntibody00000969 | ||||||
WBAntibody00001283 | |||||||
WBAntibody00001540 | |||||||
Microarray_results (39) | |||||||
Expression_cluster (223) | |||||||
Interaction (49) | |||||||
Map_info | Map | I | Position | 1.31315 | Error | 0.000496 | |
Well_ordered | |||||||
Positive | Inside_rearr | qDf16 | |||||
Positive_clone | F08B6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
K01B11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 12 | |||||
Multi_point | 18 | ||||||
19 | |||||||
250 | |||||||
251 | |||||||
310 | |||||||
346 | |||||||
1447 | |||||||
1891 | |||||||
1892 | |||||||
4602 | |||||||
Pos_neg_data | 5351 | ||||||
6549 | |||||||
6580 | |||||||
8508 | |||||||
Reference (46) | |||||||
Method | Gene |