WormBase Tree Display for Gene: WBGene00006845
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| WBGene00006845 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F11C3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-122 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F11C3.2 | ||||||||
| Molecular_name | F11C3.2 | ||||||||
| F11C3.2.1 | |||||||||
| CE51321 | |||||||||
| Other_name | ofm-1 | ||||||||
| cof-1 | CGC_data_submission | ||||||||
| CELE_F11C3.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-122 | ||||||||
| DB_info | Database | AceView | gene | 1P467 | |||||
| WormQTL | gene | WBGene00006845 | |||||||
| WormFlux | gene | WBGene00006845 | |||||||
| NDB | locus_tag | CELE_F11C3.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006845|UniProtKB=G5EGP1 | |||||||
| family | PTHR23192 | ||||||||
| NCBI | gene | 173359 | |||||||
| RefSeq | protein | NM_001322696.3 | |||||||
| TrEMBL | UniProtAcc | G5EGP1 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGP1 | |||||||
| OMIM | gene | 608603 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (81) | |||||||||
| Possibly_affected_by | WBVar02158832 | ||||||||
| Legacy_information | [C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1/ME2. NA1. [CB] | ||||||||
| Complementation_data | [Hodgkin JA] complements aex-5(sa23), unc-100(su149) | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00020596 | ||||||||
| 00020597 | |||||||||
| 00020598 | |||||||||
| 00020599 | |||||||||
| 00020600 | |||||||||
| 00020601 | |||||||||
| 00020602 | |||||||||
| 00020603 | |||||||||
| 00020604 | |||||||||
| 00020605 | |||||||||
| Ortholog (56) | |||||||||
| Paralog | WBGene00000583 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00008543 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-122 encodes a type II transmembrane protein with extracellular collagen-like repeats and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 negatively regulates cholinergic neuromuscular synaptic transmission, and is required for normal locomotion and morphology of the DVB motorneuron; mosaic analysis indicates that UNC-122 acts in muscle cells to regulate synaptic transmission and locomotory behavior; UNC-122 expression is observed in body wall muscle cells and the coelomocytes; in body wall muscles, UNC-122 localizes to the postsynaptic neuromuscular junction. | Paper_evidence | WBPaper00002665 | |||||
| WBPaper00012807 | |||||||||
| WBPaper00006427 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Jul 2015 00:00:00 | ||||||||
| Automated_description | Involved in negative regulation of cholinergic synaptic transmission. Located in postsynaptic membrane. Expressed in body wall musculature and coelomocyte. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is an ortholog of human GLDN (gliomedin) and OLFML2B (olfactomedin like 2B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060558 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29514) | ||||
| Molecular_info | Corresponding_CDS | F11C3.2 | |||||||
| Corresponding_CDS_history | F11C3.2:wp252 | ||||||||
| Corresponding_transcript | F11C3.2.1 | ||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf643864 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00030818 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089931 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090091 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044367 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089796 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090249 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram626 | ||||||||
| Chronogram1379 | |||||||||
| Expr2859 | |||||||||
| Expr2860 | |||||||||
| Expr5736 | |||||||||
| Expr1029064 | |||||||||
| Expr1032902 | |||||||||
| Expr1148310 | |||||||||
| Expr2017844 | |||||||||
| Expr2035980 | |||||||||
| Drives_construct (68) | |||||||||
| Construct_product | WBCnstr00010990 | ||||||||
| WBCnstr00034124 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction | WBInteraction000002346 | ||||||||
| WBInteraction000002347 | |||||||||
| WBInteraction000002348 | |||||||||
| WBInteraction000031893 | |||||||||
| WBInteraction000031895 | |||||||||
| WBInteraction000031896 | |||||||||
| WBInteraction000166446 | |||||||||
| WBInteraction000166447 | |||||||||
| WBInteraction000166448 | |||||||||
| WBInteraction000364445 | |||||||||
| Anatomy_function | WBbtf0275 | ||||||||
| WBbtf0276 | |||||||||
| WBbtf0277 | |||||||||
| WBbtf0278 | |||||||||
| WBbtf1052 | |||||||||
| WBbtf1053 | |||||||||
| Map_info | Map | I | Position | 27.9705 | Error | 0.034616 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F11C3 | Person_evidence | WBPerson385 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 6015 | |||||||
| Multi_point | 4455 | ||||||||
| Pos_neg_data | 5950 | ||||||||
| 5951 | |||||||||
| 5952 | |||||||||
| 5953 | |||||||||
| 5954 | |||||||||
| Reference (20) | |||||||||
| Remark | [Hodgkin JA] extracted from complex strain CB3337, isolated by Hedgecock EM | ||||||||
| Sequence connection from [Loria P, Hobert O] | |||||||||
| Method | Gene |
